Electrospinning/electrospray of polyvinylidene fluoride (PVDF): piezoelectric nanofibers

Mokhtari, Fatemeh; Latifi, Masoud; Shamshirsaz, Mahnaz

doi:10.1080/00405000.2015.1083300

Cited by 67 publications

(64 citation statements)

References 92 publications

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“…The electrospraying method has been successfully used to fabricate submicron polymerbased structures such as thin film deposition [14], capsule formation [15] and particle production [16]. The technique has various applications in microelectronics [17], optical electronics, biotechnology, environmental engineering [18], modern material and medical technologies, new DDSs and ingredients dosage fabrication in the food, cosmetic and medicine production industries [19]. Some drugs such as insulin [20], paclitaxel [21], azithromycin [22], triamcinolone acetonide [23], methylprednisolone acetate [24], ibuprofen [25], naproxen [26], etc.…”

Section: Introductionmentioning

confidence: 99%

Morphological and physicochemical evaluation of the propranolol HCl–Eudragit^® RS100 electrosprayed nanoformulations

Garjani

Barzegar-Jalali

Osouli-Bostanabad

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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The aim of this study was to fabricate propranolol hydrochloride (Prop. HCl) (as a water-soluble drug):Eudragit RS100 (Eud) nanobeads and nanofibres applying the electrospraying method as an economical and one-step technique. Different ratios of Prop. HCl:Eud (i.e. 1:5 and 1:10) at total solution concentrations of 10-20% W/V were investigated. The FE-SEM studies revealed that morphology and size of the samples were highly affected by the solution concentration; so that, the nanobeads (a mean diameter of 82.9 nm) were formed in low concentration and at the highest concentration of the solution, nanofibres (a mean diameter of 232.3 nm) were resulted. Besides the morphological changes, the size of processed nanoformulations was increased with an increment of the solution concentrations. X-ray diffraction results as well as DSC thermograms clearly indicated that the drug crystallinity decreased in the electrosprayed samples. Furthermore, in vitro dissolution test showed that the electrosprayed samples had relatively slower release patterns toward the pure drug and physical mixtures, where the samples with the drug:polymer ratio of 1:10 indicated a faster release rate toward 1:5 ratio; nevertheless, the concentration of the injected formulations did not remarkably impressed the release behaviours. The current study established the suitability of electrospraying method in the fabrication of the water-soluble drugs nanobeads/nanofibres; however, in vivo effectiveness of the prepared nanoformulations should be meticulously considered.

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Section: Introductionmentioning

confidence: 99%

Morphological and physicochemical evaluation of the propranolol HCl–Eudragit^® RS100 electrosprayed nanoformulations

Garjani

Barzegar-Jalali

Osouli-Bostanabad

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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“…Low viscosity results in insufficient polymer chain entanglement resulting in the formation of particles rather than fibers after solvent evaporation, a process that is referred to as electrospraying. Parameters that affect the morphology of electrospun fibers include the polymer flow rate, solvent system, surface tension, supplied voltage, tip‐to‐collector distance (TCD), humidity, and temperature . Increasing the concentration of the polymer can increase the diameter of the fiber in a linear or an exponential manner depending on the polymer used.…”

Section: Engineering‐based Techniquesmentioning

confidence: 99%

Fabrication Techniques for Vascular and Vascularized Tissue Engineering

Wang

Mithieux

Weiss

2019

Adv Healthcare Materials

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Impaired or damaged blood vessels can occur at all levels in the hierarchy of vascular systems from large vasculatures such as arteries and veins to meso‐ and microvasculatures such as arterioles, venules, and capillary networks. Vascular tissue engineering has become a promising approach for fabricating small‐diameter vascular grafts for occlusive arteries. Vascularized tissue engineering aims to fabricate meso‐ and microvasculatures for the prevascularization of engineered tissues and organs. The ideal small‐diameter vascular graft is biocompatible, bridgeable, and mechanically robust to maintain patency while promoting tissue remodeling. The desirable fabricated meso‐ and microvasculatures should rapidly integrate with the host blood vessels and allow nutrient and waste exchange throughout the construct after implantation. A number of techniques used, including engineering‐based and cell‐based approaches, to fabricate these synthetic vasculatures are herein explored, as well as the techniques developed to fabricate hierarchical structures that comprise multiple levels of vasculature.

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“…It is found that limited reviews emphasize the β‐phase formation and its direct effect on the piezoelectric response of electrospun PVDF nanofibers . So in the present study, two approaches in addition to the electrospinning process for β phase formation and their potential to develop the next‐generation of nanogenerators with piezo response capabilities were studied.…”

Section: Introductionmentioning

confidence: 98%

Investigation of β phase formation in piezoelectric response of electrospun polyvinylidene fluoride nanofibers: LiCl additive and increasing fibers tension

Mokhtari

Shamshirsaz

Latifi

2015

Polymer Engineering & Sci

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As a piezoelectric polymer, poly (vinylidene fluoride) (PVDF) is attractive in energy conversion applications between electrical and mechanical forms because of its low cost, high flexibility, and biocompatibility. The piezoelectricity of electrospun PVDF polymer is due to changes in the crystalline structure (e.g., creating the β‐phase) during the electrospinning process. This research focuses on two approaches for investigation of β Phase formation: (1) addition of LiCl in different concentrations (0.001, 0.00133, 0.002, 0.004 wt%) as inorganic salt to the polymer solution, (2) increasing tension along the fiber axis by increasing the collector drum speed during the aligning process. Performances of these structures were evaluated by using X‐ray diffraction (XRD), Fourier Transform Infrared (FTIR), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). A one‐step nano‐generator and cost‐effective package based on electrospun nanofibers was presented to measure output voltages as a performance factor. Results show that the addition of LiCl leads to β Phase formation in the crystalline structure, decreasing fiber diameter to 65 nm, and increment in the work of rupture and piezoelectric output. Moreover, the results show that increasing collector drum speed causes the alignment of β‐crystallites along the fiber axis and subsequently no considerable effect on the formation of β‐phases and output voltage. POLYM. ENG. SCI., 56:61–70, 2016. © 2015 Society of Plastics Engineers

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Electrospinning/electrospray of polyvinylidene fluoride (PVDF): piezoelectric nanofibers

Cited by 67 publications

References 92 publications

Morphological and physicochemical evaluation of the propranolol HCl–Eudragit^® RS100 electrosprayed nanoformulations

Morphological and physicochemical evaluation of the propranolol HCl–Eudragit^® RS100 electrosprayed nanoformulations

Fabrication Techniques for Vascular and Vascularized Tissue Engineering

Investigation of β phase formation in piezoelectric response of electrospun polyvinylidene fluoride nanofibers: LiCl additive and increasing fibers tension

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Electrospinning/electrospray of polyvinylidene fluoride (PVDF): piezoelectric nanofibers

Cited by 67 publications

References 92 publications

Morphological and physicochemical evaluation of the propranolol HCl–Eudragit® RS100 electrosprayed nanoformulations

Morphological and physicochemical evaluation of the propranolol HCl–Eudragit® RS100 electrosprayed nanoformulations

Fabrication Techniques for Vascular and Vascularized Tissue Engineering

Investigation of β phase formation in piezoelectric response of electrospun polyvinylidene fluoride nanofibers: LiCl additive and increasing fibers tension

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Morphological and physicochemical evaluation of the propranolol HCl–Eudragit^® RS100 electrosprayed nanoformulations

Morphological and physicochemical evaluation of the propranolol HCl–Eudragit^® RS100 electrosprayed nanoformulations