Electrospinning Fabrication of Poly(vinyl alcohol)/Coptis chinensis Extract Nanofibers for Antimicrobial Exploits

Yang, Seong Baek; Kim, Eun Hee; Kim, Seung Hee; Kim, Young Hun; Oh, Weontae; Lee, Jin-Tae; Jang, Young-Ah; Yeasmin, Sabina; Ji, Byung Chul; Yeum, Jeong Hyun

doi:10.3390/nano8090734

Cited by 36 publications

(20 citation statements)

References 33 publications

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“…Furthermore, BBR has a large charge density, and the large charge density increases the self-repulsion and the stretching force when droplet passes through the electrostatic field, also leads to the decrease of fiber diameter 27 . Our results are consistent with previous researchers 28 , 29 . With the fiber diameter decreasing, scaffold with higher porosity can be obtained.…”

Section: Discussionsupporting

confidence: 94%

Berberine-releasing electrospun scaffold induces osteogenic differentiation of DPSCs and accelerates bone repair

Liu

et al. 2021

Sci Rep

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The repair of skeletal defects in maxillofacial region remains an intractable problem, the rising technology of bone tissue engineering provides a new strategy to solve it. Scaffolds, a crucial element of tissue engineering, must have favorable biocompatibility as well as osteoinductivity. In this study, we prepared berberine/polycaprolactone/collagen (BBR/PCL/COL) scaffolds with different concentrations of berberine (BBR) (25, 50, 75 and 100 μg/mL) through electrospinning. The influence of dosage on scaffold morphology, cell behavior and in vivo bone defect repair were systematically studied. The results indicated that scaffolds could release BBR stably for up to 27 days. Experiments in vitro showed that BBR/PCL/COL scaffolds had appropriate biocompatibility in the concentration of 25–75 μg/mL, and 50 and 75 μg/mL scaffolds could significantly promote osteogenic differentiation of dental pulp stem cells. Scaffold with 50 μg/mL BBR was implanted into the critical bone defect of rats to evaluate the ability of bone repair in vivo. It was found that BBR/PCL/COL scaffold performed more favorable than polycaprolactone/collagen (PCL/COL) scaffold. Overall, our study is the first to evaluate the capability of in vivo bone repair of BBR/PCL/COL electrospun scaffold. The results indicate that BBR/PCL/COL scaffold has prospective potential for tissue engineering applications in bone regeneration therapy.

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Section: Discussionsupporting

confidence: 94%

Berberine-releasing electrospun scaffold induces osteogenic differentiation of DPSCs and accelerates bone repair

Liu

et al. 2021

Sci Rep

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“…Recently, electrospun poly(vinyl alcohol) nanofibrous membranes containing Coptidis Rhizoma extracts have been fabricated and shown good antibacterial activity. 26 , 27 But the effect of these membranes on wound healing and HS formation has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Palmatine-loaded electrospun poly(ε-caprolactone)/gelatin nanofibrous scaffolds accelerate wound healing and inhibit hypertrophic scar formation in a rabbit ear model

Jiang

Zhao

et al. 2020

J Biomater Appl

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Hypertrophic scar (HS) has been considered as a great concern for patients and a challenging problem for clinicians as it can cause functional debility, cosmetic disfigurement and psychological trauma. Although many methods have been developed to prevent and treat HS, the scarless healing is still a worldwide medical problem. In this study, palmatine-loaded poly( ε-caprolactone)/gelatin nanofibrous scaffolds (PCL/GE/PALs) were fabricated by electrospinning, and their effects on wound healing and HS formation were investigated. These nanofiber mats exhibit good antibacterial and antioxidant activities. In vitro studies indicate PCL/GE/PAL scaffolds can facilitate the adhesion, spreading and proliferation of L929 fibroblasts. In vivo tests demonstrate the full-thickness wounds treated with PCL/GE/PAL scaffolds heal about 3.5 days earlier than those in the control group. Scar elevation index measurements and histological analyses reveal PCL/GE/PAL scaffolds significantly inhibit HS formation, with the decrease in the thickness of dermis and epidermis, the number of fibroblasts, as well as the density of collagen and microvascular. Accelerating wound healing and inhibiting HS formation of these scaffolds are contributed to the sustained release of palmatine. The present work validates the potential use of palmatine-loaded electrospun nanofibrous scaffold PCL/GE/PALs as a functional wound dressing for healing wounds and preventing HS formation.

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“…Another biological material well-known for its good mechanical properties is the mycelium of different fungi. Usually, reports about fungicide properties of diverse nanofiber mats can be found in the scientific literature dealing with nanofiber mats and mentioning fungi [21,22,23,24,25]. Only very few studies investigate interactions between fungi and nanofiber mats in which the fungi grow on polymeric material.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Pleurotus ostreatus Mushroom Grown on Modified PAN Nanofiber Mats

et al. 2019

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Pleurotus ostreatus is a well-known edible mushroom species which shows fast growth. The fungus can be used for medical, nutritional, filter, or packaging purposes. In this study, cultivation experiments were carried out with Pleurotus ostreatus growing on polyacrylonitrile (PAN) nanofiber mats in the presence of saccharose and Lutrol F68. The aim of this study was to find out whether modified PAN nanofiber mats are well suited for the growth of fungal mycelium, to increase growth rates and to affect mycelium fiber morphologies. Our results show that Pleurotus ostreatus mycelium grows on nanofiber mats in different morphologies, depending on the specific substrate, and can be used to produce a composite from fungal mycelium and nanofiber mats for biomedical and biotechnological applications.

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Electrospinning Fabrication of Poly(vinyl alcohol)/Coptis chinensis Extract Nanofibers for Antimicrobial Exploits

Cited by 36 publications

References 33 publications

Berberine-releasing electrospun scaffold induces osteogenic differentiation of DPSCs and accelerates bone repair

Berberine-releasing electrospun scaffold induces osteogenic differentiation of DPSCs and accelerates bone repair

Palmatine-loaded electrospun poly(ε-caprolactone)/gelatin nanofibrous scaffolds accelerate wound healing and inhibit hypertrophic scar formation in a rabbit ear model

Comparative Study of Pleurotus ostreatus Mushroom Grown on Modified PAN Nanofiber Mats

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