Electrospinning for tissue engineering applications

Rahmati, Maryam; Mills, David K.; Urbanska, Aleksandra M.; Saeb, Mohammad Reza; Venugopal, Jayarama Reddy; Ramakrishna, Seeram; Mozafari, Masoud

doi:10.1016/j.pmatsci.2020.100721

Cited by 531 publications

(345 citation statements)

References 340 publications

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“…PCL was chosen as a polymer to produce biologically soluble scaffolds with HAP and AMX by the electrospinning method since this polymer is biodegradable, biocompatible, non-immunogenic, non-carcinogenic, and non-toxic, which allow obtaining composite scaffolds that are widely used in tissue engineering [35]. Moreover, the chemical and biological properties of PCL, such as biological compatibility and mechanical strength, make it possible to use it for replacement of hard tissues in the body, in which healing also takes an extended period.…”

Section: Electrospinning Of Pcl/hap/amx Based Scaffoldsmentioning

confidence: 99%

Nanofibrous biologically soluble scaffolds as an effective drug delivery system

Daulbayev¹,

Sultanov²,

Aldasheva³

et al. 2021

Comptes Rendus. Chimie

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In this article, the synthesis of biocompatible fibrous scaffolds with antimicrobial properties based on polycaprolactone/hydroxyapatite/amoxicillin and study of their surface morphology, antimicrobial effect, and drug release are discussed. Hydroxyapatite (1-2 µm, 97%) synthesized from biologically waste material (eggshell) was added to the composite scaffolds as a bone-replacement material. The scaffolds' antimicrobial properties were evaluated against S. aureus and E. faecalis. The scaffolds possessed a sustained drug release from the scaffolds amounted to about 94% of the antibiotic's total weight over a 4-week observation period. Agar diffusion confirmed the antimicrobial properties of the scaffolds against specific bacteria.

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Section: Electrospinning Of Pcl/hap/amx Based Scaffoldsmentioning

confidence: 99%

Nanofibrous biologically soluble scaffolds as an effective drug delivery system

Daulbayev¹,

Sultanov²,

Aldasheva³

et al. 2021

Comptes Rendus. Chimie

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“…Polymer fibrous scaffolds can be obtained through a variety of techniques: melt-blown technology, electrospinning, phase separation, self-assembly or template synthesis [ 1 ]. For years researchers have been focusing on fabricating nonwoven tissue scaffolds via electrospinning (ES) [ 2 , 3 ]. However, electrospinning has weaknesses that make this method difficult to apply at the industrial scale as many polymers require the use of environmentally harmful organic solvents in order to obtain electrospinning solutions [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Process Parameters on Structure and Properties of Melt-Blown Poly(Lactic Acid) Nonwovens for Skin Regeneration

Dzierzkowska

Ścisłowska-Czarnecka

Kudzin

et al. 2021

JFB

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Skin regeneration requires a three-dimensional (3D) scaffold for cell adhesion, growth and proliferation. A type of the scaffold offering a 3D structure is a nonwoven material produced via a melt-blown technique. Process parameters of this technique can be adapted to improve the cellular response. Polylactic acid (PLA) was used to produce a nonwoven scaffold by a melt-blown technique. The key process parameters, i.e., the head and air temperature, were changed in the range from 180–270 °C to obtain eight different materials (MB1–MB8). The relationships between the process parameters, morphology, porosity, thermal properties and the cellular response were explored in this study. The mean fiber diameters ranged from 3 to 120 µm. The average material roughness values were between 47 and 160 µm, whereas the pore diameters ranged from 5 to 400 µm. The calorimetry thermograms revealed a correlation between the temperature parameters and crystallization. The response of keratinocytes and macrophages exhibited a higher cell viability on thicker fibers. The cell-scaffold interaction was observed via SEM after 7 days. This result proved that the features of melt-blown nonwoven scaffolds depended on the processing parameters, such as head temperature and air temperature. Thanks to examinations, the most suitable scaffolds for skin tissue regeneration were selected.

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“…A recognized breakthrough in the field of tissue engineering includes mimicking the natural tissue architecture to achieve the desired cell response for creating 3D tissue equivalents. Among the various processing techniques, electrospinning has received substantial attention in the fabrication of scaffolds for tissue engineering, due to similar structural features of the electrospun nanofibers to the fibrillar component of natural ECM [1,2]. Nanofibers can be produced at a low cost and simple manner with the electrospinning technique.…”

Section: Graphical Abstract 1 Introductionmentioning

confidence: 99%

Facile modification of polycaprolactone nanofibers with egg white protein

Renkler

Ergene

Gokyer

et al. 2021

J Mater Sci: Mater Med

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Synthetic polymers remain to be a major choice for scaffold fabrication due to their structural stability and mechanical strength. However, the lack of functional moieties limits their application for cell-based therapies which necessitate modification and functionalization. Blending synthetic polymers with natural components is a simple and effective way to achieve the desired biological properties for a scaffold. Herein, nanofibrous mats made of polycaprolactone (PCL) and egg white protein (EWP) blend were developed and further evaluated for use as a scaffold for tissue engineering applications. Homogeneous distribution of EWP was achieved throughout the nanofibrous mats, as shown by immunohistochemistry. ATR-FTIR analysis and contact angle measurements have further confirmed the presence of EWP on the surface of the samples. The swelling test showed that PCL/EWP nanofibers have higher water uptake than PCL nanofibrous mats. Also, EWP addition on the nanofibrous mats resulted in an increase in the tensile strength and Young’s modulus of the mats, indicating that the presence of protein can greatly enhance the mechanical properties of the mats. A significantly higher, more uniform, and dispersed cell spreading was observed on days 7 and 14 than that on neat PCL mats, demonstrating the importance of providing the required cues for cell homing by the availability of EWP. Hence, EWP is shown to be a simple and low-cost source for the functionalization of PCL nanofibrous mats. EWP is, therefore, a facile candidate to enhance cellular interactions of synthetic polymers for a wide range of tissue engineering applications.

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Electrospinning for tissue engineering applications

Cited by 531 publications

References 340 publications

Nanofibrous biologically soluble scaffolds as an effective drug delivery system

Nanofibrous biologically soluble scaffolds as an effective drug delivery system

Effects of Process Parameters on Structure and Properties of Melt-Blown Poly(Lactic Acid) Nonwovens for Skin Regeneration

Facile modification of polycaprolactone nanofibers with egg white protein

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