Electrospinning for tissue engineering scaffolds

Lannutti, John J.; Reneker, Darrell H.; Ma, Teng; Tomasko, David L.; Farson, Dave F.

doi:10.1016/j.msec.2006.05.019

Cited by 613 publications

(412 citation statements)

References 34 publications

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“…Electrospinning is a fastest growing trend in the production of fibers in laboratory to industrial scale [23][24][25][26]. Recently, these techniques have become popular due to their ability to produce various classes of ultrafine fibers such as polymer, ceramics, metals, composite etc., with diameters in the range several micrometers down to tens of nanometers.…”

Section: Electrospinning: a Fascinating Technique For Nanofiber Fabrimentioning

confidence: 99%

See 1 more Smart Citation

Nanofibrous Structure of Chitosan for Biomedical Applications

Bhattarai¹

2012

J Nanomedic Biotherapeu Discover

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Section: Electrospinning: a Fascinating Technique For Nanofiber Fabrimentioning

confidence: 99%

“…Polymer and solution properties such as molecular weight, viscosity, conductivity, and surface tension are very important parameters to control the fibers size and morphology. Some other parameters which can change the electrospinning process are applied voltage, tip-to-collector distance, feeding rate, etc [23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Nanofibrous Structure of Chitosan for Biomedical Applications

Bhattarai¹

2012

J Nanomedic Biotherapeu Discover

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“…Traditional scaffold fabrication techniques have included the production of porous polymer constructs by freeze-extraction and -gelation [5], electrospinning [6], melt electrospinning [7,8] or with hydrogels [9][10][11][12] as substrates for cell attachment.…”

Section: Introductionmentioning

confidence: 99%

In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization

et al. 2016

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The manufacture of 3D scaffolds with specific controlled porous architecture, defined microstructure and an adjustable degradation profile was achieved using two-photon polymerization (TPP) with a size of 2 × 4 × 2 mm3. Scaffolds made from poly(D,L-lactide-co-ɛ-caprolactone) copolymer with varying lactic acid (LA) and ɛ -caprolactone (CL) ratios (LC16:4, 18:2 and 9:1) were generated via ring-opening-polymerization and photoactivation. The reactivity was quantified using photo-DSC, yielding a double bond conversion ranging from 70% to 90%. The pore sizes for all LC scaffolds were see 300 μm and throat sizes varied from 152 to 177 μm. In vitro degradation was conducted at different temperatures; 37, 50 and 65 °C. Change in compressive properties immersed at 37 °C over time was also measured. Variations in thermal, degradation and mechanical properties of the LC scaffolds were related to the LA/CL ratio. Scaffold LC16:4 showed significantly lower glass transition temperature (Tg) (4.8 °C) in comparison with the LC 18:2 and 9:1 (see 32 °C). Rates of mass loss for the LC16:4 scaffolds at all temperatures were significantly lower than that for LC18:2 and 9:1. The degradation activation energies for scaffold materials ranged from 82.7 to 94.9 kJ mol−1. A prediction for degradation time was applied through a correlation between long-term degradation studies at 37 °C and short-term studies at elevated temperatures (50 and 65 °C) using the half-life of mass loss (Time (M1/2)) parameter. However, the initial compressive moduli for LC18:2 and 9:1 scaffolds were 7 to 14 times higher than LC16:4 (see 0.27) which was suggested to be due to its higher CL content (20%). All scaffolds showed a gradual loss in their compressive strength and modulus over time as a result of progressive mass loss over time. The manufacturing process utilized and the scaffolds produced have potential for use in tissue engineering and regenerative medicine applications.

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“…Electrospinning is a technology to produce polymer fiber by using electrical forces. It can produce nanosize diameter of fibers from both natural and synthetic polymers [3][4][5][6]. This process offers unique capabilities to produce natural nanofibers with controlled pore structure [7,8].…”

Section: Introductionmentioning

confidence: 99%

Electrospinning optimization and characterization of Chitosan/Alginate/Polyvinyl alcohol nanofibers

Kusumastuti¹,

Putri²,

Dary³

2016

AIP Conference Proceedings

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Abstract. Nanofiber is a widely used biopolymer in medical and industrial applications due to its unique characteristics such as the high surface area to volume ratio and its biocompatibility. This work demonstrates the ability of polyion complex chitosan-alginate to form nanofiber with the addition of polyvinyl alcohol (PVA) by electrospinning. The electrospinning process offers a unique capability to produce natural nanofibers with controlled pore structure using both natural and synthesis polymer or its combination. This research was conducted to optimize the fabrication of chitosan/alginate/PVA nanofibers by varying the conductivity of solution, solvent concentration, and polymer composition. The obtained nanofibers were characterized using Scanning Electron Microscope (SEM) to observe the morphology and Fourier Transform Infrared (FTIR) identify the constituent group. Nanofibers have achieved with the range of mixture solution's conductivity of 0.5-2.0 Mho/cm. The resulted nanofibers showed a uniform nanofiber with average diameter around 200-400 nm. Although higher acetic acid concentration (as a chitosan solvent) did not change conductivity significantly, it resulted in a larger diameter of nanofibers. Higher sodium alginate concentration in the mixture solution produced nanofibers with higher conductivity and larger diameter.

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Electrospinning for tissue engineering scaffolds

Cited by 613 publications

References 34 publications

Nanofibrous Structure of Chitosan for Biomedical Applications

Nanofibrous Structure of Chitosan for Biomedical Applications

In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization

Electrospinning optimization and characterization of Chitosan/Alginate/Polyvinyl alcohol nanofibers

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