Electrospinning-netting of spider-inspired polycaprolactone/collagen nanofiber-nets incorporated with Propolis extract for enhanced wound healing applications

Doodmani, Seyed Mohammad; Bagheri, Afsaneh; Natouri, Ozra; Nobakht, Abbas; Saghebasl, Solmaz

doi:10.1016/j.ijbiomac.2024.131452

Cited by 8 publications

(1 citation statement)

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“…Thus, it can further affect the mechanical properties, plasticity, biocompatibility, and degradability of the nanofiber, and thus the repair efficiency of the tissue [26]. PCL-COL nanofibers are also used in many areas of tissue engineering, such as wound dressing [27], vascular graft [28], bone and cartilage [26], and drug delivery system [29] are also used.…”

Section: Introductionmentioning

confidence: 99%

Development of bilayer tissue-engineered scaffolds: combination of 3D printing and electrospinning methodologies

Yilmaz,

Bedir,

Gursoy

et al. 2024

Biomed. Mater.

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Although different fabrication methods and biomaterials are used in scaffold development, hydrogels and electrospun materials that provide the closest environment to the extracellular matrix (ECM) have recently attracted considerable interest in tissue engineering applications. However, some of the limitations encountered in the application of these methods alone in scaffold fabrication have increased the tendency to use these methods together. In this study, a bilayer scaffold was developed using 3D-printed gelatin methacryloyl (GelMA) hydrogel containing ciprofloxacin (CIP) and electrospun polycaprolactone (PCL)-collagen (COL) patches. The bilayer scaffolds were characterized in terms of chemical, morphological, mechanical, swelling, and degradation properties; drug release, antibacterial properties, and cytocompatibility of the scaffolds were also studied. In conclusion, bilayer GelMA-CIP/PCL-COL scaffolds, which exhibit sufficient porosity, mechanical strength, and antibacterial properties and also support cell growth, are promising potential substitutes in tissue engineering applications.

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