Electrospinning of Biodegradable Polymer Scaffolds

Bychuk, M. A.; Кильдеева, Н. Р.; Kurinova, M. A.; Bogdanov, N. V.; Kalinin, M. V.; Новиков, А. В.; Вихорева, Г. А.

doi:10.1007/s10692-015-9618-9

Cited by 6 publications

(3 citation statements)

References 3 publications

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“…The formation of such structures may be due to the high viscosity of P3HB solution. According to literature sources, the viscosity of the P3HB solution varies from 4 to 60 Pa•s [38] , which makes it difficult to obtain microparticles with a high production yield. However, the low molecular weight polymer (100 kDa) was ideal to obtain a good quality of microparticles, and the production yield was also increased up to 85% (Table 1).…”

Section: Results and Discussion Properties Of Spray-dried P3hb Micropmentioning

confidence: 99%

Novel spray-dried PHA microparticles for antitumor drug release

et al. 2017

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The production of poly-3-hydroxybutyrate and poly-3-hydroxybutyrate/polyethylene glycol-based microparticles, loaded with antitumor drugs Paclitaxel (PTX) and 5-Fluorouracil (5-FU) by spray-drying technique was investigated. The average diameter of microparticles was found to be 3.4 ± 0.5 µm and zeta potential was about-44 mV. The addition of surfactant (PEG) did not show any effect on the morphological characteristics of the particles. But the chemical structure of drug influenced on the properties. Microparticles had heterogeneous pores on the surface when the hydrophobic PTX was encapsulated. For 5-FU loading microparticles, were established that the addition of surfactant positively influenced on the properties of particles and led to the loading of drug directly into the matrix. This is confirmed by the results of electron microscopy and dynamics of drug release in vitro. As a whole, the release profiles of PTX and 5-FU from composite P3HB/PEG-microparticles were less than from P3HBmicroparticles. The results of the morphological evaluation of Hela cells demonstrated that the use of cytostatic drugs loaded in P3HB microparticles induces morphological changes associated with apoptosis (chromatin condensation, core fragmentation, margination of nucleus). Thus, the obtained results can serve as the basis for the development of new antitumor drugs of prolonged action, intended for various modes of administration.

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Section: Results and Discussion Properties Of Spray-dried P3hb Micropmentioning

confidence: 99%

Novel spray-dried PHA microparticles for antitumor drug release

et al. 2017

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“…Joshua Avossa, et al [ 142 ] designed a nanofibrous conductive chemical sensor based on two insulating polymers (PS and PHB, named as PsB) doped with H 2 TPP and graphene which were selected for being versatile, biodegradable, eco-compatible, recyclable (PS) [ 148 , 149 ] and resistant to thermal excursions. The sensor indicated non-linear relationships between the conductivity and the temperature ( Figure 10 d).…”

Section: Graphene/conducting Polymer Nanocomposites For Chemiresismentioning

confidence: 99%

Recent Trends and Developments in Graphene/Conducting Polymer Nanocomposites Chemiresistive Sensors

Zamiri

Haseeb

2020

Materials

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The use of graphene and its derivatives with excellent characteristics such as good electrical and mechanical properties and large specific surface area has gained the attention of researchers. Recently, novel nanocomposite materials based on graphene and conducting polymers including polyaniline (PANi), polypyrrole (PPy), poly (3,4 ethyldioxythiophene) (PEDOT), polythiophene (PTh), and their derivatives have been widely used as active materials in gas sensing due to their unique electrical conductivity, redox property, and good operation at room temperature. Mixing these two materials exhibited better sensing performance compared to pure graphene and conductive polymers. This may be attributed to the large specific surface area of the nanocomposites, and also the synergistic effect between graphene and conducting polymers. A variety of graphene and conducting polymer nanocomposite preparation methods such as in situ polymerization, electropolymerization, solution mixing, self-assembly approach, etc. have been reported and utilization of these nanocomposites as sensing materials has been proven effective in improving the performance of gas sensors. Review of the recent research efforts and developments in the fabrication and application of graphene and conducting polymer nanocomposites for gas sensing is the aim of this review paper.

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“…Porphyrin, due to its molecular structure, is expected to give a significant contribution to the sensing properties of the polymer composite fibers [ 23 ], by coordinating the planar surfaces of MGC and the phenyl rings of PS (effects on fiber morphology and structure) and “capturing” selectively volatile organic compounds (VOCs) (effects on sensor sensitivity and selectivity). The polymers were selected because they are versatile (widely used in many consumer products), eco-compatible, biodegradable (PHB), recyclable (PS) [ 33 , 34 ] and resistant to thermal excursions (thermoplastics). Additionally, they are both soluble in chloroform and insoluble in H 2 O, meaning that they could be deposited by a unique electrospun mixture with a single needle, and were expected to be stable to changes in environmental humidity.…”

Section: Introductionmentioning

confidence: 99%

Electrospinning of Polystyrene/Polyhydroxybutyrate Nanofibers Doped with Porphyrin and Graphene for Chemiresistor Gas Sensors

et al. 2019

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Structural and functional properties of polymer composites based on carbon nanomaterials are so attractive that they have become a big challenge in chemical sensors investigation. In the present study, a thin nanofibrous layer, comprising two insulating polymers (polystyrene (PS) and polyhydroxibutyrate (PHB)), a known percentage of nanofillers of mesoporous graphitized carbon (MGC) and a free-base tetraphenylporphyrin, was deposited onto an Interdigitated Electrode (IDE) by electrospinning technology. The potentials of the working temperature to drive both the sensitivity and the selectivity of the chemical sensor were studied and described. The effects of the porphyrin combination with the composite graphene–polymer system appeared evident when nanofibrous layers, with and without porphyrin, were compared for their morphology and electrical and sensing parameters. Porphyrin fibers appeared smoother and thinner and were more resistive at lower temperature, but became much more conductive when temperature increased to 60–70 °C. Both adsorption and diffusion of chemicals seemed ruled by porphyrin according its combination inside the composite fiber, since the response rates dramatically increased (toluene and acetic acid). Finally, the opposite effect of the working temperature on the sensitivity of the porphyrin-doped fibers (i.e., increasing) and the porphyrin-free fibers (i.e., decreasing) seemed further confirmation of the key role of such a macromolecule in the VOC (volatile organic compound) adsorption.

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Electrospinning of Biodegradable Polymer Scaffolds

Cited by 6 publications

References 3 publications

Novel spray-dried PHA microparticles for antitumor drug release

Novel spray-dried PHA microparticles for antitumor drug release

Recent Trends and Developments in Graphene/Conducting Polymer Nanocomposites Chemiresistive Sensors

Electrospinning of Polystyrene/Polyhydroxybutyrate Nanofibers Doped with Porphyrin and Graphene for Chemiresistor Gas Sensors

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