Electrospinning of Chitosan for Antibacterial Applications—Current Trends

Antaby, Eliconda; Klinkhammer, Kristina; Sabantina, Lilia

doi:10.3390/app112411937

Cited by 47 publications

(22 citation statements)

References 206 publications

(260 reference statements)

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“…64 Therefore, high acid concentrations are needed (70–90%) with low to medium molecular weights to generate pure chitosan fibers or, more commonly, polymeric blends with either hydrophilic polymers (polyethylene oxide (PEO), PVA) or hydrophobic polymers (PCL, Nylon) are used to decrease repulsion by hydrogen bonding. 65,66…”

Section: Electrospinning With Green Solventsmentioning

confidence: 99%

“…64 Therefore, high acid concentrations are needed (70-90%) with low to medium molecular weights to generate pure chitosan fibers or, more commonly, polymeric blends with either hydrophilic polymers (polyethylene oxide (PEO), PVA) or hydrophobic polymers (PCL, Nylon) are used to decrease repulsion by hydrogen bonding. 65,66 Geng et al electrospun CS fibers with an average diameter of 130 nm from aqueous 90% AcOH solution containing 7 wt% of polymer. The authors reported that the acid content should be higher than 30%, a requirement for CS fiber formation, because more concentrated acetic acid decreased surface tension of the CS solution and increased charge density.…”

Section: Polymers Electrospun With Green Solventsmentioning

confidence: 99%

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Electrospinning based on benign solvents: current definitions, implications and strategies

et al. 2022

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Section: Electrospinning With Green Solventsmentioning

confidence: 99%

Section: Polymers Electrospun With Green Solventsmentioning

confidence: 99%

Electrospinning based on benign solvents: current definitions, implications and strategies

et al. 2022

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“…Chitosan has been vastly exploited for the treatment of acute and chronic wounds, because it can stimulate hemostasis and induce tissue regeneration [ 163 , 164 ]. Furthermore, it exhibits antimicrobial activity against a wide variety of bacteria and fungi due to its cationic nature, which is influenced by the degree of deacetylation and molecular weight [ 165 , 166 ]. Already, chitosan-based wound dressings exist commercially in the form of hydrogels, sponges, films, and nonwovens [ 164 ].…”

Section: Marine Animal-derived Biopolymersmentioning

confidence: 99%

Marine Biopolymers as Bioactive Functional Ingredients of Electrospun Nanofibrous Scaffolds for Biomedical Applications

et al. 2022

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Marine biopolymers, abundantly present in seaweeds and marine animals, feature diverse structures and functionalities, and possess a wide range of beneficial biological activities. Characterized by high biocompatibility and biodegradability, as well as unique physicochemical properties, marine biopolymers are attracting a constantly increasing interest for the development of advanced systems for applications in the biomedical field. The development of electrospinning offers an innovative technological platform for the production of nonwoven nanofibrous scaffolds with increased surface area, high encapsulation efficacy, intrinsic interconnectivity, and structural analogy to the natural extracellular matrix. Marine biopolymer-based electrospun nanofibrous scaffolds with multifunctional characteristics and tunable mechanical properties now attract significant attention for biomedical applications, such as tissue engineering, drug delivery, and wound healing. The present review, covering the literature up to the end of 2021, highlights the advancements in the development of marine biopolymer-based electrospun nanofibers for their utilization as cell proliferation scaffolds, bioadhesives, release modifiers, and wound dressings.

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“…Despite the high potential of CS and HA for regenerative medicine applications, electrospinning pure polymeric solutions is difficult because of their insufficient rheological properties, high surface tension, limited solubility, and poor mechanical characteristics . To overcome the electrospinning limitations of natural polymers and the repulsion forces between the charged groups, electrospinning was performed using composite nanofibers from natural and synthetic polymers .…”

Section: Introductionmentioning

confidence: 99%

Cross-Linked Electrospun pH-Sensitive Nanofibers Adsorbed with Temporin-Ra for Promoting Wound Healing

Koohzad

Asoodeh

2023

ACS Appl. Mater. Interfaces

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Bioresponsive nanodrug delivery systems have excellent potential in tissue engineering applications. Poly-anionic and poly-cationic biopolymers have provided a superior platform for designing pH-sensitive drug delivery systems. In this regard, hyaluronic acid–chitosan–polyvinyl alcohol complex nanofibers with high quality and reproducibility were produced by optimizing the solution preparation process. In addition, the synthesized composite nanofiber, with 66.82 kN/mm toughness, 200% swelling ratio, and 60% porosity, exhibited excellent properties to meet the requirements of the ideal wound dressing. Green cross-linking with citric acid prevented the destruction of the nanofiber even after prolonged immersion in biological solutions. ζ potential studies demonstrated that the synthesized nanofiber has a negative surface charge (∼−30) at physiological pH. The pK a of the temporin-Ra peptide is about 10, and as a result the peptide molecules have a net positive charge in physiological conditions. Therefore, peptide molecules immobilized on the synthesized scaffold based on surface adsorption. In vivo evaluation has proven that the wound bed has an alkaline environment, facilitating peptide release from the nanofiber scaffold. Electrospun nanofibers can imitate the architecture of the extracellular matrix for accelerating wound healing. In vitro investigation showed better adhesion, proliferation, migration, and fibroblast cell growth on peptide-loaded nanofiber samples than other groups. In vivo studies on full-thickness wounds in the mouse model indicated that the designed nanofiber was gradually absorbed without causing dryness or infection. On day 6, the peptide-loaded nanofiber revealed 60% wound closure compared to the control group (17%). In addition, based on histological studies, the composite nanofiber demonstrated excellent tissue repair ability, hence these active nanofiber mats can be a good alternative to existing wound dressings. Gene expression studies show that the antimicrobial peptide promotes the inflammatory phase of wound healing in a shorter time frame by accelerating the tumor necrosis factor-α cytokine response.

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Electrospinning of Chitosan for Antibacterial Applications—Current Trends

Cited by 47 publications

References 206 publications

Electrospinning based on benign solvents: current definitions, implications and strategies

Electrospinning based on benign solvents: current definitions, implications and strategies

Marine Biopolymers as Bioactive Functional Ingredients of Electrospun Nanofibrous Scaffolds for Biomedical Applications

Cross-Linked Electrospun pH-Sensitive Nanofibers Adsorbed with Temporin-Ra for Promoting Wound Healing

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