Electrospinning of chitosan nanofibrous structures: feasibility study

Vrieze, Sander De; Westbroek, Philippe; Camp, Tamara Van; Langenhove, Lieva Van

doi:10.1007/s10853-006-1485-6

Cited by 149 publications

(94 citation statements)

References 27 publications

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“…Average fiber diameters and size distribution decreased with increasing electric field and more bead defects appeared at 5 kV/cm or more. In addition, Vrieze et al [18] attempted a range of acid aqueous solutions such as formic acid, acetic acid, lactic acid and hydrochloric acid for developing chitosan nanofibres by electrospinning. The study showed that chitosan nanofibres with a diameter of about 70±45 nm were obtained from a concentrated acetic acid solution (90%) with a 3% chitosan concentration at an applied voltage of 2.0 kV/cm and a flow rate of 0.3 ml/h.…”

Section: Electrospinning Of Chitosan 21 Electrospinning Of Pure Chimentioning

confidence: 99%

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Sun¹,

Li²

2011

Express Polym. Lett.

218

101

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Chitosan is soluble in most acids. The protonation of the amino groups on the chitosan backbone inhibits the electrospinnability of pure chitosan. Recently, electrospinning of nanofibers based on chitosan has been widely researched and numerous nanofibers containing chitosan have been prepared by decreasing the number of the free amino groups of chitosan as the nanofibiers have enormous possibilities for better utilization in various areas. This article reviews the preparations and properties of the nanofibers which were electrospun from pure chitosan, blends of chitosan and synthetic polymers, blends of chitosan and protein, chitosan derivatives, as well as blends of chitosan and inorganic nanoparticles, respectively. The applications of the nanofibers containing chitosan such as enzyme immobilization, filtration, wound dressing, tissue engineering, drug delivery and catalysis are also summarized in detail

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Section: Electrospinning Of Chitosan 21 Electrospinning Of Pure Chimentioning

confidence: 99%

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Sun¹,

Li²

2011

Express Polym. Lett.

218

101

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“…CS is the deacetylated form of the second most abundant polysaccharide chitin (N-acetyl-D-glucosamine), which provides the exoskeletons of arthropods and crustaceans with structural integrity. CS can be electrospun either neat [2][3][4][5][6] from a variety of solvents, such as trifluoroacetic acid (TFA) and hexafluoroisopropanol [7], or with copolymers such as polyethylene oxide [8,9] and polyvinyl alcohol [10].…”

Section: Introductionmentioning

confidence: 99%

New crosslinkers for electrospun chitosan fibre mats. Part II: mechanical properties

Donius

Kiechel

Schauer

et al. 2013

J. R. Soc. Interface.

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Few studies exist on the mechanical performance of crosslinked electrospun chitosan (CS) fibre mats. In this study, we show that the mat structure and mechanical performance depend on the different crosslinking agents genipin, epichlorohydrin (ECH), and hexamethylene-1,6-diaminocarboxysulphonate (HDACS), as well as the post-electrospinning heat and base activation treatments. The mat structure was imaged by field emission scanning electron microscopy and the mechanical performance was tested in tension. The elastic modulus, tensile strength, strain at failure and work to failure were found to range from 52 to 592 MPa, 2 to 30 MPa, 2 to 31 per cent and 0.041 to 3.26 MJ m 23 , respectively. In general, neat CS mats were found to be the stiffest and the strongest, though least ductile, while CS -ECH mats were the least stiff, weakest, but the most ductile, and CS -HDACS fibre mats exhibited intermediary mechanical properties. The mechanical performance of the mats is shown to reflect differences in the fibre diameter, number of fibre-fibre contacts formed within the mat, as well as varying intermolecular bonding and moisture content. The findings reported here complement the chemical properties of the mats, described in part I of this study.

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“…It was noted that the surface tension and charge density were the key factors in determining the spinnability of the system. In preliminary attempts to produce chitosan nanofibers for wound or alternate medical applications, or the removal of metals from solutions for environmental applications, Vrieze et al, 2007 conducted a feasibility study concerning the electrospinning of chitosan in formic, acetic, lactic and hydrochloric acids. It was determined that only the use of concentrated aq acetic acid solutions resulted in fibers.…”

Section: Electrospinning Of Chitosanmentioning

confidence: 99%

Perspectives of Chitin and Chitosan Nanofibrous Scaffolds in Tissue Engineering

Jayakumar¹,

Nair²,

Furuike³

et al. 2010

Tissue Engineering

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Chitin and its deacetylated derivative, chitosan, are non-toxic, biodegradable biopolymers currently being developed for use in biomedical applications such as tissue engineering scaffolds, wound dressings, separation membranes, antibacterial coatings, stent coatings, and sensors. Recently, nano fibrous scaffolds based on chitin or chitosan have potential applications in tissue engineering. Tissue engineering is one of the most exciting interdisciplinary and multidisciplinary research areas today, and there has been exponential growth in the number of research publications in this area in recent years. It involves the use of living cells, manipulated through their extracellular environment or genetically to develop biological substitutes for implantation into the body and/or to foster remodeling of tissues in some active manners. Electrospun chitin and chitosan nano fibrous scaffolds would be used to produce tissue engineering scaffolds with improved cytocompatibility, which could mimic the native extracellular matrix (ECM). Electrospinning is truly a feasible means of producing nano fibrous scaffolds that resemble the ECM, however, moreover than this, it is imperative that the effects of an artificial matrix has on cell growth, proliferation, and differentiation. This review summarizes the recent progress in chitin and chitosan based nano fibrous scaffolds with an emphasis in tissue engineering applications.

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Electrospinning of chitosan nanofibrous structures: feasibility study

Cited by 149 publications

References 27 publications

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

New crosslinkers for electrospun chitosan fibre mats. Part II: mechanical properties

Perspectives of Chitin and Chitosan Nanofibrous Scaffolds in Tissue Engineering

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