Electrospinning of PLGA/gum tragacanth nanofibers containing tetracycline hydrochloride for periodontal regeneration

Ranjbar‐Mohammadi, Marziyeh; Zamani, Maedeh; Prabhakaran, Molamma P.; Bahrami, S. Hajir; Ramakrishna, Seeram

doi:10.1016/j.msec.2015.08.066

Cited by 168 publications

(89 citation statements)

References 37 publications

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“…Gum tragacanth, an anionic polysaccharide, provides a more sustained release of hydrophilic drug TCH, which is important to treat the periodontal disease. Using the coaxial structure, TCH can be released up to 75 days with a small initial burst release of ∼19 % within 2 hr . Another combination with PEI (polyethylenimine)/pBMP2 (bone morphogenetic protein‐2 plasmid) core and PLGA sheath was demonstrated for periodontal regeneration, delivering pBMP2 to human periodontal ligament stem cells (hPDLSCs).…”

Section: Recent Results and Applicationsmentioning

confidence: 99%

Coaxial Electrospinning Formation of Complex Polymer Fibers and their Applications

2019

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The formation of fibers by electrospinning has experienced explosive growth in the past decade, recently reaching 4,000 publications and 1,500 patents per year. This impressive growth of interest is due to the ability to form fibers with a variety of materials, which lend themselves to a large and rapidly expanding set of applications. In particular, coaxial electrospinning, which forms fibers with multiple core−sheath layers from different materials in a single step, enables the combination of properties in a single fiber that are not found in nature in a single material. This article is a detailed review of coaxial electrospinning: basic mechanisms, early history and current status, and an in‐depth discussion of various applications (biomedical, environmental, sensors, energy, catalysis, textiles). We aim to provide readers who are currently involved in certain aspects of coaxial electrospinning research an appreciation of other applications and of current results.

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Section: Recent Results and Applicationsmentioning

confidence: 99%

Coaxial Electrospinning Formation of Complex Polymer Fibers and their Applications

2019

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“…Therefore, the intended application for the sustained release fibers often dictates the polymer selection. Both non-biodegradable and biodegradable polymers have been used for sustained release from electrospun fibers [35, 36]. The most prevalent polymers used in electrospun fibers for sustained release are biodegradable polyesters such as polylactic acid (PLA), polyglycolic acid (PGA), poly (lactic-co-glycolic) acid (PLGA), and polycaprolactone (PCL) [37].…”

Section: Materials Compositions For Sustained Drug Release From Elementioning

confidence: 99%

Current strategies for sustaining drug release from electrospun nanofibers

Chou

Carson

Woodrow

2015

Journal of Controlled Release

437

278

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Electrospun drug-eluting fibers are emerging as a novel dosage form for multipurpose prevention against sexually transmitted infections, including HIV, and unintended pregnancy. Previous work from our lab and others show the versatility of this platform to deliver large doses of physico-chemically diverse agents. However, there is still an unmet need to develop practical fiber formulations for water-soluble small molecule drugs needed at high dosing due to intrinsic low potency or desire for sustained prevention. To date, most sustained release fibers have been restricted to the delivery of biologics or hydrophobic small molecules at low drug loading of typically < 1 wt.%, which is often impractical for most clinical applications. For hydrophilic small molecule drugs, their high aqueous solubility and poor partitioning and incompatibility with insoluble polymers make long-term release even more challenging. Here we investigate several existing strategies to sustain release of hydrophilic small molecule drugs that are highly-loaded in electrospun fibers. In particular, we investigate what is known about the design constraints required to realize multi-day release from fibers fabricated from uniaxial and coaxial electrospinning.

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“…Additionally, incorporation of nano-HA crystals not only increases the osteogenic potential of these scaffolds but it has also been suggested that these scaffolds have mechanical properties superior to those made of PCL alone [131]. Another exciting prospect of using electrospun scaffolds is their ability to function as carriers of growth factors and drugs such as bone morphogenic protein-2 (BMP2) and antibiotics which can enhance bone regeneration and prevent periodontal infections [83,84]. …”

Section: Electrospun Nanofibers For Dental Applicationsmentioning

confidence: 99%

Potential of Electrospun Nanofibers for Biomedical and Dental Applications

et al. 2016

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Electrospinning is a versatile technique that has gained popularity for various biomedical applications in recent years. Electrospinning is being used for fabricating nanofibers for various biomedical and dental applications such as tooth regeneration, wound healing and prevention of dental caries. Electrospun materials have the benefits of unique properties for instance, high surface area to volume ratio, enhanced cellular interactions, protein absorption to facilitate binding sites for cell receptors. Extensive research has been conducted to explore the potential of electrospun nanofibers for repair and regeneration of various dental and oral tissues including dental pulp, dentin, periodontal tissues, oral mucosa and skeletal tissues. However, there are a few limitations of electrospinning hindering the progress of these materials to practical or clinical applications. In terms of biomaterials aspects, the better understanding of controlled fabrication, properties and functioning of electrospun materials is required to overcome the limitations. More in vivo studies are definitely required to evaluate the biocompatibility of electrospun scaffolds. Furthermore, mechanical properties of such scaffolds should be enhanced so that they resist mechanical stresses during tissue regeneration applications. The objective of this article is to review the current progress of electrospun nanofibers for biomedical and dental applications. In addition, various aspects of electrospun materials in relation to potential dental applications have been discussed.

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Electrospinning of PLGA/gum tragacanth nanofibers containing tetracycline hydrochloride for periodontal regeneration

Cited by 168 publications

References 37 publications

Coaxial Electrospinning Formation of Complex Polymer Fibers and their Applications

Coaxial Electrospinning Formation of Complex Polymer Fibers and their Applications

Current strategies for sustaining drug release from electrospun nanofibers

Potential of Electrospun Nanofibers for Biomedical and Dental Applications

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