Electrospinning of poly(decamethylene terephthalate) to support vascular graft applications

Voorde, Babs Van de; Sensu, Berna; Vos, Lobke De; Colenbier, Robin; Baskan, Havva; Geltmeyer, Jozefien; Parmentier, Laurens; Daele, Lenny Van; Dmitriev, Ruslan I.; Pyl, Lincy; Clerck, Karen De; Vlierberghe, Sandra Van

doi:10.1016/j.eurpolymj.2022.111003

Cited by 9 publications

(4 citation statements)

References 55 publications

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“…Recently, however, these materials have been investigated for their use in cardiovascular applications. Because of the lower Young’s moduli of PATs (i.e., <1 GPa) compared to PET, PTT, and PBT (i.e., >1 GPa), as well as their potential as substrates for vascular endothelial cells, these materials have shown great potential for biomedical applications (e.g., as a coronary artery bypass graft). ,− Another added benefit of PATs with longer alkyl chain lengths is that they typically have lower melting temperatures than PET, PTT, and PBT, allowing for melt-processing at lower temperatures (i.e., <180 °C compared to >240 °C for PET, PTT, and PBT). ,− Notwithstanding these recent developments, the thermomechanical and other properties of PATs remain underinvestigated, leaving a lot of application potential unexplored.…”

Section: Introductionmentioning

confidence: 99%

Catalyst-Free Single-Step Solution Polycondensation of Polyesters: Toward High Molar Masses and Control over the Molar Mass Range

et al. 2023

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Poly(alkylene terephthalate)s are frequently used polymers serving a plethora of applications, including packaging, textiles, and biomedical applications. However, their current synthesis procedures have some limitations, such as harsh reaction conditions and requirement of a catalyst. Furthermore, there is no control over the molar mass and only polymers with limited molar masses can be obtained. New optimized synthesis methods are therefore desired. To this end, we further improved our previously reported catalyst-free single-step solution polycondensation. By varying the comonomer ratio of both monomers, we gained control over the molar mass range and obtained polymers with number-average molar masses up to 187 kg/mol. Furthermore, by using a small excess of diol, we obtained polymers with alcohol end groups, allowing further functionalization. Finally, the melt recrystallization behavior for all investigated polymers was demonstrated using modulated differential scanning calorimetry. In conclusion, the synthesis method described in this paper circumvents the disadvantages of the current synthesis procedures.

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Section: Introductionmentioning

confidence: 99%

Catalyst-Free Single-Step Solution Polycondensation of Polyesters: Toward High Molar Masses and Control over the Molar Mass Range

et al. 2023

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“…The polymers were synthesized according to the protocol reported by Van de Voorde et al, which is slightly adapted from Giol et al 39,45 In short, equimolar amounts of the monomers (i.e. a diol and terephthaloyl chloride) together with dichlorobenzene (solvent) were loaded in a flask equipped with a condenser and reacted under stirring and inert gas flow at temperatures ranging between 160 and 175 1C for up to 24 hours, depending on the desired molar mass, after which it was precipitated in cold disinfectol and filtered.…”

Section: Polymer Synthesismentioning

confidence: 99%

Effect of molar mass and alkyl chain length on the surface properties and biocompatibility of poly(alkylene terephthalate)s for potential cardiovascular applications

Van Daele,

Van de Voorde,

Colenbier

et al. 2023

J. Mater. Chem. B

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“…[66,67] When the resulting polymers were assessed by in vitro biological evaluation, we found that they enabled adhesion and proliferation of endothelial cells (ECs) and that they outperformed PET. [68,69] This makes them very appealing for cardiovascular applications, where endothelialization is crucial. [57,[70][71][72] Some PATs (including PET and poly(butylene terephthalate) (PBT)) have also demonstrated shape memory behavior, further increasing their potential as stent materials.…”

Section: Introductionmentioning

confidence: 99%

3D‐Printed Shape Memory Poly(alkylene terephthalate) Scaffolds as Cardiovascular Stents Revealing Enhanced Endothelialization

Van Daele,

Chausse,

Parmentier

et al. 2024

Adv Healthcare Materials

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Cardiovascular diseases are the leading cause of death and current treatments such as stents still suffer from disadvantages. Balloon expansion causes damage to the arterial wall and limited and delayed endothelialization gives rise to restenosis and thrombosis. New more performing materials that circumvent these disadvantages are required to improve the success rate of interventions. To this end, we investigated the use of a novel polymer, poly(hexamethylene terephthalate), for this application. We optimized the synthesis to obtain polymers with high molar masses up to 126.5 kg/mol and performed a thorough chemical and thermal analysis. We 3D‐printed the polymers into personalized cardiovascular stents using the state‐of‐the‐art solvent‐cast direct‐writing technique, established the potential of these stents to expand using their shape memory behavior and showed that the stents are more resistant to compression than the PLLA benchmark. Furthermore, we demonstrated the polymer's hydrolytic stability in an accelerated degradation study of six months. Finally, the stents were subjected to an in vitro biological evaluation, revealing that the polymer is non‐hemolytic and supports significant endothelialization after only 7 days, demonstrating the enormous potential of these polymers to serve cardiovascular applications.This article is protected by copyright. All rights reserved

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Electrospinning of poly(decamethylene terephthalate) to support vascular graft applications

Cited by 9 publications

References 55 publications

Catalyst-Free Single-Step Solution Polycondensation of Polyesters: Toward High Molar Masses and Control over the Molar Mass Range

Catalyst-Free Single-Step Solution Polycondensation of Polyesters: Toward High Molar Masses and Control over the Molar Mass Range

Effect of molar mass and alkyl chain length on the surface properties and biocompatibility of poly(alkylene terephthalate)s for potential cardiovascular applications

3D‐Printed Shape Memory Poly(alkylene terephthalate) Scaffolds as Cardiovascular Stents Revealing Enhanced Endothelialization

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