Electrospinning of polyhydroxyalkanoate fibrous scaffolds: effects on electrospinning parameters on structure and properties

Volova, Tatiana G.; Goncharov, Dmitriy; Sukovatyi, Alexey G.; Shabanov, A. V.; Nikolaeva, Elena D.; Shishatskaya, Ekaterina I.

doi:10.1080/09205063.2013.862400

Cited by 57 publications

(34 citation statements)

References 43 publications

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“…The deposition distance is a well-known parameter in conventional ES process4041. When the collector speed, flow rate, applied voltage and PCL/PVP solution concentration were fixed at 80 mm/s, 0.4 mL/h, 2.0 kV and 25 w/v %, respectively, an increased working distance impacted fiber resolution.…”

Section: Resultsmentioning

confidence: 99%

Preparation of active 3D film patches via aligned fiber electrohydrodynamic (EHD) printing

Wang

Zheng²,

Chang

et al. 2017

Sci Rep

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The design, preparation and application of three-dimensional (3D) printed structures have gained appreciable interest in recent times, particularly for drug dosage development. In this study, the electrohydrodynamic (EHD) printing technique was developed to fabricate aligned-fiber antibiotic (tetracycline hydrochloride, TE-HCL) patches using polycaprolactone (PCL), polyvinyl pyrrolidone (PVP) and their composite system (PVP-PCL). Drug loaded 3D patches possessed perfectly aligned fibers giving rise to fibrous strut orientation, variable inter-strut pore size and controlled film width (via layering). The effect of operating parameters on fiber deposition and alignment were explored, and the impact of the film structure, composition and drug loading was evaluated. FTIR demonstrated successful TE-HCL encapsulation in aligned fibers. Patches prepared using PVP and TE-HCL displayed enhanced hydrophobicity. Tensile tests exhibited changes to mechanical properties arising from additive effects. Release of antibiotic from PCL-PVP dosage forms was shown over 5 days and was slower compared to pure PCL or PVP. The printed patch void size also influenced antibiotic release behavior. The EHDA printing technique provides an exciting opportunity to tailor dosage forms in a single-step with minimal excipients and operations. These developments are crucial to meet demands where dosage forms cannot be manufactured rapidly or when a personalized approach is required.

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Section: Resultsmentioning

confidence: 99%

Preparation of active 3D film patches via aligned fiber electrohydrodynamic (EHD) printing

Wang

Zheng²,

Chang

et al. 2017

Sci Rep

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“…Growth of human keratinocyte cell line HaCat on the nanofiber PHA matrices showed an enhanced improvement over those on PHA matrices prepared via an ordinary solution casting method [27]. None of the fibrous scaffolds produced by electrospinning from PHAs had any adverse effects on attachment, growth, and viability of NIH 3T3 mouse fibroblast cells, and all of them were found to be suitable for tissue engineering applications [28].…”

Section: Applications As Medical Implant Materialsmentioning

confidence: 96%

Polyhydroxyalkanoates (PHA) for therapeutic applications

Zhang

Shishatskaya

Volova

et al. 2018

Materials Science and Engineering: C

197

106

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As intracellular carbon and energy storage materials, polyhydroxyalkanoates (PHA) are a diverse biopolyesters synthesized by many bacteria. PHA have been produced in large quantity for various application research including medical implants for approximately 30years. Many studies demonstrated that PHA are promising implant materials due to their diverse and ascendant mechanical, biodegradable and tissue compatible properties. Importantly, common PHA biodegradation products including oligomers and monomers are also not toxic to the cells and tissues. Pharmaceutical applications of some PHA degradation products also have been reported. So far, no study has been reported to have any carcinogenesis result induced by any PHA or their biodegradation products. All results suggest that PHA could be developed into various bio-implant products.

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“…Overall, the prototype of PDT-chemo stent has demonstrated the proof of concept of localized combination therapy for cholangiocarcinoma. Based on the theory, the drug-releasing rate could be further regulated by changing the initial electrospraying blend polymer solution, concentration, structure and type of fibers and the amount of additives for the clinical needs [34, 35]. …”

Section: Resultsmentioning

confidence: 99%

Prototype of biliary drug-eluting stent with photodynamic and chemotherapy using electrospinning

et al. 2014

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BackgroundThe combination of biliary stent with photodynamic and chemotherapy seemed to be a beneficial palliative treatment of unresectable cholangiocarcinoma. However, by intravenous delivery to the target tumor the distribution of the drug had its limitations and caused serious side effect on non-target organs. Therefore, in this study, we are going to develop a localized eluting stent, named PDT-chemo stent, covered with gemcitabine (GEM) and hematoporphyrin (HP).MethodsThe prototype of PDT-chemo stent was made through electrospinning and electrospraying dual-processes with an electrical charge to cover the stent with a drug-storing membrane from polymer liquid. The design of prototype used PU as the material of the backing layer, and PCL/PEG blends in different molar ratio of 9:1 and of 1:4 were used in two drug-storing layers with GEM and HP loaded respectively.ResultsThe optical microscopy revealed that the backing layer was formed in fine fibers from electrospinning, while drug-storing layers, attributed to the droplets from electrospraying process. The covered membrane, the morphology of which was observed by scanning electron microscopy (SEM), covered the stent surface homogeneously without crack appearances. The GEM had almost 100% of electrosprayed efficiency than 70% HP loaded on the covered membrane due to the different solubility of drug in PEG/PCL blends. Drug release study confirmed the two-phased drug release pattern by regulating in different molar ratio of PEG/PCL blends polymer.ConclusionsThe result proves that the PDT-chemo stent is composed of a first burst-releasing phase from HP and a later slow-releasing phase from GEM eluting. This two-phase of drug eluting stent may provide a new prospect of localized and controlled release treatment for cholangiocarcinoma disease.

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Electrospinning of polyhydroxyalkanoate fibrous scaffolds: effects on electrospinning parameters on structure and properties

Cited by 57 publications

References 43 publications

Preparation of active 3D film patches via aligned fiber electrohydrodynamic (EHD) printing

Preparation of active 3D film patches via aligned fiber electrohydrodynamic (EHD) printing

Polyhydroxyalkanoates (PHA) for therapeutic applications

Prototype of biliary drug-eluting stent with photodynamic and chemotherapy using electrospinning

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