Electrospinning of polymeric nanofibers for drug delivery applications

Hu, Xiuli; Liu, Shi; Zhou, Guangyuan; Huang, Yubin; Xie, Zhigang; Jing, Xiabin

doi:10.1016/j.jconrel.2014.04.018

Cited by 1,063 publications

(656 citation statements)

References 105 publications

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“…With respect to fabrication methods, electro-spinning (Figure 4) appears to be the method of choice, as aligned nano-to micro-fibrous scaffolds can be produced with mechanical and structural features similar to the tissue to be replaced and with ability to control permanently differentiated and stem cell fate in vitro; to locally deliver in a controlled manner pharmacological agents, biological molecules and cells at the side of injury; and to enhance directional neotissue formation [404][405][406][407][408][409]. Although electro-spun collagen scaffolds have demonstrated improved neotissue alignment and mechanical properties, over control counterparts in a rabbit Achilles tendon model [410] the realisation that the use of fluoro-alcohols denatures the triple helical confirmation of collagen [411,412] has reduced further investigations.…”

Section: Bottom-up Approached For Tendon Repair Based On Synthetic Inmentioning

confidence: 99%

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

183

188

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Section: Bottom-up Approached For Tendon Repair Based On Synthetic Inmentioning

confidence: 99%

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

183

188

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“…Their prominent features for electrospinning used in drug delivery are cost-effectiveness, high loading capacity, ease of operation, high encapsulation efficiency, and simultaneous delivery of various therapies [129]. …”

Section: Localized Drug Delivery Systemsmentioning

confidence: 99%

Possible role of nanocarriers in drug delivery against cervical cancer

Gupta

2017

Nano Reviews & Experiments

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Introduction: Cervical cancer is the second most common cancer and the largest cancer killer among women in most developing countries including India. Although, various drugs have been developed for cervical cancer, treatment with these drugs often results in a number of undesirable side effects, toxicity and multidrug resistance (MDR). Also, the outcomes for cervical cancer patients remain poor after surgery and chemo radiation. Methods: A literature search (for drugs and delivery systems against cervical cancer) was performed on PubMed and through Google. The present review discuss about various methods including its current conventional treatment with special reference to recent advances in delivery systems encapsulating various anticancer drugs and natural plant products for targeting towards cervical cancer. The role of photothermal therapy, gene therapy and radiation therapy against cervical cancer is also discussed. Results: Systemic/targeted drug delivery systems including liposomes, nanoparticles, hydrogels, dendrimers etc. and localized drug delivery systems like cervical patches, films, rings etc. are safer than the conventional chemotherapy which has further been proved by the several drug delivery systems undergoing clinical trials. Conclusion: Novel approaches for the aggressive treatment of cervical cancer will optimistically result in decreased side effects as well as toxicity, frequency of administration of existing drugs, to overcome MDR and to increase the survival rates.

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“…It was first observed in 1897 by Rayleigh, studied in detail by Zeleny on electrospraying in 1914, and patented by Formhals in 1934 [1]. The electrospinning process may be considered the most promising of all nanotechnologies, due to versatility and cost to produce nanofibers [2,3], with large surface area, porosity, orientation, and dimensions in a controlled manner with excellent mechanical and easy functionalization properties for multiple applications [2][3][4][5][6][7][8]. This technique has a variety of applications such as it is shown in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Influence of the molecular weight of polymer, solvents and operational condition in the electrospinning of polycaprolactone

Colmenares-Roldan

Quintero-Martinez

Agudelo-Gomez

et al. 2017

Rev. Fac. Ing. Univ. Antioquia

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ABSTRACT:The objective of this study was to determine the influence of the molecular weight of polycaprolactone, solvents and operational conditions to obtain polymeric nanofibers by the electrospinning technique. In this study, an electrospinning equipment constructed at University was employed, in which you can control the process parameters such as voltage, deposition rate, collector distance, speed and direction of rotation of the collector. In this paper, polycaprolactone (PCL) of three different Molecular Weight (Mw=14,000 g·mol , and Mw=80,000 g·mol -1 ) was used. Solvents used were Acetone and mixtures of Acetone with Acetic Acid in different ratios. The tests carried out showed that polycaprolactone of 14,000 g·mol -1 did not allow getting fibers. While the tests carried out with polycaprolactone of 45,000 g·mol -1 and 80,000 g·mol -1 allowed getting fibers under the different conditions evaluated. The higher concentration of the polymer provokes the solution of the polymer does not flow through the tip of the syringe, while the low concentration of the polymer favors that the fibers break and defects appear in the film. In this study, it was found that using a voltage of 15 KV, an injection rate of 0.1 mL/h and a collector distance from 15 cm with PCL solution of 45,000 g·mol -1 at 20% in solution 1:1 of acetone and acetic acid, it was possible to obtain the highest percentage of nanofibers from all experiments (77%) with an average diameter of 88 nm. RESUMEN:El objetivo de este trabajo fue determinar la influencia del peso molecular de la policaprolactona, solventes y condiciones operacionales para obtener nanofibras poliméricas mediante la técnica de electrospinning. Para este trabajo, se utilizó un equipo de electrospinning construido en la Universidad Pontificia Bolivariana, en el cual se pudieron controlar los parámetros del proceso como el voltaje, la velocidad de deposición y la distancia del colector. Además, para este trabajo se utilizó policaprolactona (PCL) de tres pesos moleculares diferentes (Mw = 14.000 g·mol ). Los disolventes empleados fueron acetona y mezclas de acetona con ácido acético en diferentes proporciones. Los ensayos realizados mostraron que la policaprolactona de 14.000 g·mol -1 bajo ninguna de las condiciones evaluadas permitió obtener fibras, mientras que los ensayos realizados con policaprolactona de 45.000 y 80.000 g·mol -1 sí permitieron obtener fibras bajo las diferentes condiciones evaluadas. La mayor concentración del polímero dificulta el paso de la solución por punta de la jeringa, mientras que la baja concentración del polímero favorece que las fibras se rompan y aparezcan gotas en la película. En este estudio se encontró que, empleando un voltaje de 15 KV, un flujo de inyección de 0,1 mL/h y una distancia del colector de 15 cm para una solución de PCL de 45.000 g·mol -1 al 20% en acetona, ácido acético 1:1, se logra obtener el mayor porcentaje de nanofibras de todos los experimentos, 77% con un diámetro promedio de 88 nm aproximadamente.

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Electrospinning of polymeric nanofibers for drug delivery applications

Cited by 1,063 publications

References 105 publications

The past, present and future in scaffold-based tendon treatments

The past, present and future in scaffold-based tendon treatments

Possible role of nanocarriers in drug delivery against cervical cancer

Influence of the molecular weight of polymer, solvents and operational condition in the electrospinning of polycaprolactone

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