Electrospinning of polysaccharides for regenerative medicine

Lee, Kuen Yong; Jeong, Lim; Kang, Yun Ok; Lee, Seung Jin; Park, Won Ho

doi:10.1016/j.addr.2009.07.006

Cited by 492 publications

(279 citation statements)

References 131 publications

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“…"Green" electrospinning technology relies on the development of non-toxic, inexpensive and environmentally friendly polymers and solvents (such as water or ionic solvents) for the fabrication of electrospun fibres and membranes. Electrospun natural biodegradable polymers have shown great applicability in many fields such as the development of filtration membranes, catalytic nanofibres, tissue engineering, drug delivery and sensors [140,141]. The application of electrospun nanofibres in the area of biomedicine, drug delivery, tissue engineering, wound dressing, water purification, and energy has been reported [142][143][144].…”

Section: "Green" Electrospinning Based On Tree Gumsmentioning

confidence: 99%

Green Synthesis: Nanoparticles and Nanofibres Based on Tree Gums for Environmental Applications

Padil

Černík

2016

Ecological Chemistry and Engineering S

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Abstract:The recent advances and potential applications of nanoparticles and nanofibres for energy, water, food, biotechnology, the environment, and medicine have immensely conversed. The present review describes a 'green' method for the synthesis and stabilization of nanoparticles and 'green electrospinning' both using tree gums (arabic, tragacanth, karaya and kondagogu). Furthermore, this review focuses on the impending applications of both gum stabilized nanoparticles and functionalized membranes in remediation of toxic metals, radioactive effluents, and the adsorptive removal of nanoparticulates from aqueous environments as well as from industrial effluents. Besides, the antibacterial properties of gum derivatives, gum stabilized nanoparticles, and functionalized electrospun nanofibrous membranes will also be highlighted. The functionalities of nanofibrous membranes that can be enhanced by various plasma treatments (oxygen and methane, respectively) will also be emphasized.

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Section: "Green" Electrospinning Based On Tree Gumsmentioning

confidence: 99%

Green Synthesis: Nanoparticles and Nanofibres Based on Tree Gums for Environmental Applications

Padil

Černík

2016

Ecological Chemistry and Engineering S

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“…There are several methods to create nanofibers; such as drawing, template synthesis, phase separation, selfassembly, and electrospinning [2]. Among these methods, electrospinning appears to be the most fascinating process.…”

Section: Introductionmentioning

confidence: 99%

“…Chitosan is a cationic polysaccharide and has been widely used in biomedical application. It has some interesting properties such as biocompatibility and biodegradability, cellular binding capability, acceleration of wound healing process, hemostatic properties, antibacterial and antifungal properties [2]. Alginate is an anionic polysaccharide that has excellent biocompatibility, low toxicity, non-immunogenicity, and simple gelation behavior with divalent cations such as Ca 2+ , Mg 2+ , Ba 2+ , and Sr 2+ [11].…”

Section: Introductionmentioning

confidence: 99%

Electrospinning optimization and characterization of Chitosan/Alginate/Polyvinyl alcohol nanofibers

Kusumastuti¹,

Putri²,

Dary³

2016

AIP Conference Proceedings

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Abstract. Nanofiber is a widely used biopolymer in medical and industrial applications due to its unique characteristics such as the high surface area to volume ratio and its biocompatibility. This work demonstrates the ability of polyion complex chitosan-alginate to form nanofiber with the addition of polyvinyl alcohol (PVA) by electrospinning. The electrospinning process offers a unique capability to produce natural nanofibers with controlled pore structure using both natural and synthesis polymer or its combination. This research was conducted to optimize the fabrication of chitosan/alginate/PVA nanofibers by varying the conductivity of solution, solvent concentration, and polymer composition. The obtained nanofibers were characterized using Scanning Electron Microscope (SEM) to observe the morphology and Fourier Transform Infrared (FTIR) identify the constituent group. Nanofibers have achieved with the range of mixture solution's conductivity of 0.5-2.0 Mho/cm. The resulted nanofibers showed a uniform nanofiber with average diameter around 200-400 nm. Although higher acetic acid concentration (as a chitosan solvent) did not change conductivity significantly, it resulted in a larger diameter of nanofibers. Higher sodium alginate concentration in the mixture solution produced nanofibers with higher conductivity and larger diameter.

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“…Such fibers have been produced in dry process (natural method) with limited pollution and benign environmental impact for various applications. In woundcare applications, electrospun fibers have been produced whether from medicated polymers (Lee et al, 2009;Nada et al, 2014) or from polymers incorporated with active agents (Charernsriwilaiwat et al, 2013;Taepaiboon et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Nicotinamide into Cellulose Based Electrospun Fibers

Nada¹,

Hassabo²,

Mohamed³

et al. 2016

J App Pharm Sci

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Systematic application of topical drugs has been widely prescribed as an effective treatment for skin disorders. However, the widespread use of such topical drugs is also associated with emergence of resistant strains of microorganisms resulting in patients resist for one or more antibiotics. Nicotinamide, a water-soluble amide of nicotinic acid and a common topical drug, is approved as anti-acne drug with anti-inflammatory potentials. Encapsulation of nicotinamide into electrospun water-soluble matrix that chemically crosslinked is the approach to control its release. In this research, biocompatible nano-fibrous mat was developed with hydroxyethyl cellulose (HEC) blended with poly(vinyl alcohol) (PVA) by electro-spinning technique. The concentration of HEC (5% w/v) with PVA (10% w/v) was optimized, blended in different ratios (20-50% HEC concentration) and electro-spun to get smooth nano-fibers. Nicotinamide was successfully encapsulated in the electro-spun fibers. Nicotinamide release was controlled via chemical cross-linking of the produced mat. Selected parameters of spinning solutions (viscosity and conductivity) and process parameters (applied voltage and needle-to-collector distance) were studied. The microstructure, morphology of blended HEC/PVA, nicotinamide -loaded nano-fiber, cross-linked HEC/PVA nano-fibrous scaffolds were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR). SEM images showed that the mean diameters of blend nanofibers were ranged from 80 to 60 nm. The release profile of the nicotinamide was demonstrated. Release profile of the uncrosslinked and crosslinked mats were demonstred. Immortalized human skin fibroblasts cells were used to examine the biocompatibility of the produced HEC/PVA/ nicotinamide electrospun mats.

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Electrospinning of polysaccharides for regenerative medicine

Cited by 492 publications

References 131 publications

Green Synthesis: Nanoparticles and Nanofibres Based on Tree Gums for Environmental Applications

Green Synthesis: Nanoparticles and Nanofibres Based on Tree Gums for Environmental Applications

Electrospinning optimization and characterization of Chitosan/Alginate/Polyvinyl alcohol nanofibers

Encapsulation of Nicotinamide into Cellulose Based Electrospun Fibers

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