Electrospinning of reconstituted silk fiber from aqueous silk fibroin solution

Cao, Hui; Chen, Xin; Huang, Lei; Shao, Zhengzhong

doi:10.1016/j.msec.2009.05.012

Cited by 93 publications

(72 citation statements)

References 38 publications

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“…Silk fibroin was degummed from silk cocoon in boiling 0.5 % (w/w) Na 2 CO 3 solution with a bath ratio of 1:50 and then washed with deionized water to remove silk sericin (Cao et al 2009a). …”

Section: Methodsmentioning

confidence: 99%

Morphology and properties of cellulose/silk fibroin blend fiber prepared with 1-butyl-3-methylimidazolium chloride as solvent

et al. 2014

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1-Butyl-3-methylimidazolium chloride ([BMIM]Cl) was selected as co-solvent to dissolve cellulose and silk fibroin and the cellulose/silk fibroin blend fibers were fabricated with dry-jet wet spinning technology. The phase morphology of cellulose and silk fibroin in the blend fibers was studied by scanning electron microcopy and laser scanning confocal microscope. It is shown that the cellulose is in the continuous phase and silk fibroin exists as ''fibril-like'' in cellulose, in which the radial dimension of silk fibroin phase is 0.5-1.0 lm. The phase size of silk fibroin along the fiber axis increased with the increase of silk fibroin content and draw ratio. From the wideangle X-ray scattering, it is found that the total crystallinity of the blend fibers decreased with increasing silk fibroin content. The hydrogen bond between cellulose and silk fibroin was observed from Fourier transform infrared spectra. Although the tensile strength and initial modulus of blend fibers decreased with increasing silk fibroin content, the tensile strength of blend fibers contain 35 wt% silk fibroin was up to 191 MPa.

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Section: Methodsmentioning

confidence: 99%

Morphology and properties of cellulose/silk fibroin blend fiber prepared with 1-butyl-3-methylimidazolium chloride as solvent

et al. 2014

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“…In most of prior studies about the electrospinning of SF solution, the SF spinning dopes were also formed by using organic solvents [11][12][13][14], or further blending with poly (ethylene oxide), chitosan, collagen and other synthetic or nature polymers [15][16][17]. Only few researches were implemented using water as solvent and pure SF aqueous solution as spinning dope [18][19][20]. No composite spinning process using SF aqueous solution as core dope and SS aqueous solution as shell dope has been reported.…”

Section: Introductionmentioning

confidence: 99%

Preparation of regenerated silk fibroin/silk sericin fibers by coaxial electrospinning

Hang

Zhang

Jin

et al. 2012

International Journal of Biological Macromolecules

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“…Silk solution was previously used in various forms such as 3D porous scaffold, electrospun fibers, thin film, hydrogel, and microsphere [36–43]; most works have been done on self-assembly processes.…”

Section: Discussionmentioning

confidence: 99%

Investigate the Effect of Thawing Process on the Self-Assembly of Silk Protein for Tissue Applications

Nguyen

Luong

Nguyen

et al. 2017

BioMed Research International

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Biological self-assembly is a process in which building blocks autonomously organize to form stable supermolecules of higher order and complexity through domination of weak, noncovalent interactions. For silk protein, the effect of high incubating temperature on the induction of secondary structure and self-assembly was well investigated. However, the effect of freezing and thawing on silk solution has not been studied. The present work aimed to investigate a new all-aqueous process to form 3D porous silk fibroin matrices using a freezing-assisted self-assembly method. This study proposes an experimental investigation and optimization of environmental parameters for the self-assembly process such as freezing temperature, thawing process, and concentration of silk solution. The optical images demonstrated the possibility and potential of −80ST48 treatment to initialize the self-assembly of silk fibroin as well as controllably fabricate a porous scaffold. Moreover, the micrograph images illustrate the assembly of silk protein chain in 7 days under the treatment of −80ST48 process. The surface morphology characterization proved that this method could control the pore size of porous scaffolds by control of the concentration of silk solution. The animal test showed the support of silk scaffold for cell adhesion and proliferation, as well as the cell migration process in the 3D implantable scaffold.

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Electrospinning of reconstituted silk fiber from aqueous silk fibroin solution

Cited by 93 publications

References 38 publications

Morphology and properties of cellulose/silk fibroin blend fiber prepared with 1-butyl-3-methylimidazolium chloride as solvent

Morphology and properties of cellulose/silk fibroin blend fiber prepared with 1-butyl-3-methylimidazolium chloride as solvent

Preparation of regenerated silk fibroin/silk sericin fibers by coaxial electrospinning

Investigate the Effect of Thawing Process on the Self-Assembly of Silk Protein for Tissue Applications

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