Electrospinning technologies for the delivery of Biopharmaceuticals: Current status and future trends

Lian, Shangjie; Lamprou, Dimitrios; Zhao, Min

doi:10.1016/j.ijpharm.2023.123641

Cited by 20 publications

(3 citation statements)

References 257 publications

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“…The electrospinning technique has several advantages: It is simple, elegant, reproducible, continuous, and scalable 25 . Therefore, many research groups have focused on creating improved scaffolds to simulate the functions of natural skin substitutes 26 .…”

Section: Discussionmentioning

confidence: 99%

Sulfated Chitosan Nanofibrous Scaffolds Seeded With Adipose Stem Cells Promote Ischemic Wound Healing in a Proangiogenic Strategy

Zhang,

Jiao,

Shen

et al. 2024

Cell Transplant

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Ischemic wounds are chronic wounds with poor blood supply that delays wound reconstruction. To accelerate wound healing and promote angiogenesis, adipose-derived stem cells (ADSCs) are ideal seed cells for stem cell–based therapies. Nevertheless, providing a favorable environment for cell proliferation and metabolism poses a substantial challenge. A highly sulfated heparin-like polysaccharide 2-N, 6-O-sulfated chitosan (26SCS)-doped poly(lactic-co-glycolic acid) scaffold (S-PLGA) can be used due to their biocompatibility, mechanical properties, and coagent 26SCS high affinity for growth factors. In this study, a nano-scaffold system, constructed from ADSCs seeded on electrospun fibers of modified PLGA, was designed to promote ischemic wound healing. The S-PLGA nanofiber membrane loaded with adipose stem cells ADSCs@S-PLGA was prepared by a co-culture in vitro, and the adhesion and compatibility of cells on the nano-scaffolds were explored. Scanning electron microscopy was used to observe the growth state and morphological changes of ADSCs after co-culture with PLGA electrospun fibers. The proliferation and apoptosis after co-culture were detected using a Cell Counting Kit-8 kit and flow cytometry, respectively. An ischemic wound model was then established, and we further studied the ability of ADSCs@S-PLGA to promote wound healing and angiogenesis. We successfully established ischemic wounds on the backs of rats and demonstrated that electrospun fibers combined with the biological effects of adipose stem cells effectively promoted wound healing and the growth of microvessels around the ischemic wounds. Phased research results can provide a theoretical and experimental basis for a new method for promoting clinical ischemic wound healing.

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Section: Discussionmentioning

confidence: 99%

Sulfated Chitosan Nanofibrous Scaffolds Seeded With Adipose Stem Cells Promote Ischemic Wound Healing in a Proangiogenic Strategy

Zhang,

Jiao,

Shen

et al. 2024

Cell Transplant

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“…Although the assembly of the electrospinning apparatus and product collection are relatively simple, the optimization of experimental parameters necessary for the fabrication of uniform and reproducible scaffolds requires extensive experimentation. For a detailed overview of the key parameters affecting the electrospinning process, readers are referred to other recent publications in this field (Abdulhussain et al, 2023;Godakanda et al, 2022;Lian et al, 2024;Zare et al, 2021). It is essential to consider native tissue morphology and the anticipated function of the electrospun scaffold before initial formulation and fabrication.…”

Section: Tailoring Electrospinning Process To Produce Scaffolds For N...mentioning

confidence: 99%

Electrospun drug‐loaded scaffolds for nervous system repair

Kellaway,

Ullrich,

Dziemidowicz

2024

WIREs Nanomed Nanobiotechnol

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Nervous system injuries, encompassing peripheral nerve injury (PNI), spinal cord injury (SCI), and traumatic brain injury (TBI), present significant challenges to patients' wellbeing. Traditional treatment approaches have limitations in addressing the complexity of neural tissue regeneration and require innovative solutions. Among emerging strategies, implantable materials, particularly electrospun drug‐loaded scaffolds, have gained attention for their potential to simultaneously provide structural support and controlled release of therapeutic agents. This review provides a thorough exploration of recent developments in the design and application of electrospun drug‐loaded scaffolds for nervous system repair. The electrospinning process offers precise control over scaffold characteristics, including mechanical properties, biocompatibility, and topography, crucial for creating a conducive environment for neural tissue regeneration. The large surface area of the resulting fibrous networks enhances biomolecule attachment, influencing cellular behaviors such as adhesion, proliferation, and migration. Polymeric electrospun materials demonstrate versatility in accommodating a spectrum of therapeutics, from small molecules to proteins. This enables tailored interventions to accelerate neuroregeneration and mitigate inflammation at the injury site. A critical aspect of this review is the examination of the interplay between structural properties and pharmacological effects, emphasizing the importance of optimizing both aspects for enhanced therapeutic outcomes. Drawing upon the latest advancements in the field, we discuss the promising outcomes of preclinical studies using electrospun drug‐loaded scaffolds for nervous system repair, as well as future perspectives and considerations for their design and implementation.This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Therapeutic Approaches and Drug Discovery > Emerging Technologies

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“…An essentially lower number of papers were devoted to this system's fabrication in ultrathin fibrillar forms obtained by electrospinning. This non-sophisticated technique opens a new horizon for the production and application of nano-and microfibers in such promising technologies as water treatment, designing 3D scaffolds for tissue engineering, fabrication of smart nonwoven textiles, and electro-writing [28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Polylactide—Poly(ε-Caprolactone) Fibers: Structure Characterization and Segmental Dynamic Response

Karpova,

Olkhov,

Varyan

et al. 2024

Polymers

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Electrospun ultrathin fibers based on binary compositions of polylactide (PLA) and poly(ε-caprolactone) (PCL) with the various content from the polymer ratio from 0/100 to 100/0 have been explored. Combining thermal (DSC) and spectropy (ESR) techniques, the effect of biopolymer content on the characteristics of the crystal structure of PLA and PCL and the rotative diffusion of the stable TEMPO radical in the intercrystallite areas of PLA/PCL compositions was shown. It was revealed that after PLA and PCL blending, significant changes in the degree of crystallinity of PLA, PCL segment mobility, sorption of the Tempo probe, as well as its activation energy of rotation in the intercrystalline areas of PLA/PCL fibers, were evaluated. The characteristic region of biopolymers’ composition from 50/50 to 30/70% PLA/PCL blend ratio was found, where the inversion transition of PLA from dispersive medium to dispersive phase where an inversion transition is assumed when the continuous medium of the PLA transforms into a discrete phase. The performed studies made it possible, firstly, to carry out a detailed study of the effect of the system component ratio on the structural and dynamic characteristics of the PLA/PCL film material at the molecular level.

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Electrospinning technologies for the delivery of Biopharmaceuticals: Current status and future trends

Cited by 20 publications

References 257 publications

Sulfated Chitosan Nanofibrous Scaffolds Seeded With Adipose Stem Cells Promote Ischemic Wound Healing in a Proangiogenic Strategy

Sulfated Chitosan Nanofibrous Scaffolds Seeded With Adipose Stem Cells Promote Ischemic Wound Healing in a Proangiogenic Strategy

Electrospun drug‐loaded scaffolds for nervous system repair

Electrospun Polylactide—Poly(ε-Caprolactone) Fibers: Structure Characterization and Segmental Dynamic Response

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