Electrospray deposition of titanium dioxide (TiO2) nanoparticles

Halimi, S.; Bakar, Noor Fitrah Abu; Ismail, Siti Norazian; Hashib, Syafiza Abd; Naim, Mohd Nazli

doi:10.1063/1.4866730

Cited by 14 publications

(10 citation statements)

References 7 publications

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“…In these experiments, no chemical or physical carriers were used to bind particles to the mask surface; however, several methods are available for coating different matrices, including textiles or other materials used for face masks and PPE (Table 2) [71][72][73][74][75][76][77][78][79][80]. For example, among the different available techniques, the combination of natural polymers, such as chitosan (CS) with inorganic materials, such as titanium dioxide (TiO 2 ), to obtain hybrid composites (CS-TiO 2 ), seems promising for both increased stability and enhanced antimicrobial properties [81,82].…”

Section: Discussionmentioning

confidence: 99%

“…[ 71,72] Electrospray A suspension of TiO 2 is dissolved in a polar solvent, nebulized at atmospheric pressure inside the ionization chamber through a needle held at a high electric potential. [73] Dip coating, spray coating Deposition of a wet liquid film by immersion of the fabric into a solution containing hydrolysable metal compounds (or readily formed particles) and its withdrawal at a constant speed into an atmosphere containing water vapor. [74,75] Irradiation under UV-A Textile immersion in a suspension of TiO 2 , then squeezed and immediately irradiated under UVA 100 W lamp for 1 h.…”

Section: Application Methods Description Referencementioning

confidence: 99%

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Photocatalytic Treatments for Personal Protective Equipment: Experimental Microbiological Investigations and Perspectives for the Enhancement of Antimicrobial Activity by Micrometric TiO2

Margarucci

Gianfranceschi

Spica

et al. 2021

IJERPH

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The COVID-19 pandemic has led to countries enforcing the use of facial masks to prevent contagion. However, acquisition, reuse, and disposal of personal protective equipment (PPE) has generated problems, in regard to the safety of individuals and environmental sustainability. Effective strategies to reprocess and disinfect PPE are needed to improve the efficacy and durability of this equipment and to reduce waste load. Thus, the addition of photocatalytic materials to these materials, combined with light exposure at specific wavelengths, may represent promising solutions. To this aim, we prepared a series of masks by depositing micrometer-sized TiO2 on the external surfaces; the masks were then contaminated with droplets of bacteria suspensions and the coatings were activated by light radiation at different wavelengths. A significant reduction in the microbial load (over 90%, p < 0.01) was observed using both Gram negative (E. coli) and Gram positive (S. aureus) bacteria within 15 min of irradiation, with UV or visible light, including sunlight or artificial sources. Our results support the need for further investigations on self-disinfecting masks and other disposable PPE, which could positively impact i) the safety of operators/workers, and ii) environmental sustainability in different occupational or recreational settings.

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Section: Discussionmentioning

confidence: 99%

Section: Application Methods Description Referencementioning

confidence: 99%

Photocatalytic Treatments for Personal Protective Equipment: Experimental Microbiological Investigations and Perspectives for the Enhancement of Antimicrobial Activity by Micrometric TiO2

Margarucci

Gianfranceschi

Spica

et al. 2021

IJERPH

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“…The liquid used is a polymeric solution, or formulation, containing three main components (a solvent, polymer and active drug) and possibly other excipients. This technique has been widely used by researchers for various drug delivery therapies e.g., insulin [ 39 ], folic acid [ 40 ], titanium dioxide antimicrobial agent [ 41 ], gold used in gene delivery [ 42 ] etc. The EHDA system can generate both particles (electrospraying) and fibers (electrospinning).…”

Section: Microneedle Coating Methodsmentioning

confidence: 99%

Microneedle Coating Techniques for Transdermal Drug Delivery

et al. 2015

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Drug administration via the transdermal route is an evolving field that provides an alternative to oral and parenteral routes of therapy. Several microneedle (MN) based approaches have been developed. Among these, coated MNs (typically where drug is deposited on MN tips) are a minimally invasive method to deliver drugs and vaccines through the skin. In this review, we describe several processes to coat MNs. These include dip coating, gas jet drying, spray coating, electrohydrodynamic atomisation (EHDA) based processes and piezoelectric inkjet printing. Examples of process mechanisms, conditions and tested formulations are provided. As these processes are independent techniques, modifications to facilitate MN coatings are elucidated. In summary, the outcomes and potential value for each technique provides opportunities to overcome formulation or dosage form limitations. While there are significant developments in solid degradable MNs, coated MNs (through the various techniques described) have potential to be utilized in personalized drug delivery via controlled deposition onto MN templates.

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“…As TDN suspension has large positive or negative zeta potential, particles in suspension will tend to repel from each other which prevents aggregation and agglomeration of the particles. 17 The morphology was investigated by a high-resolution transmission electron microscope ( Figure 2). Images showed that the prepared nanoparticles were nearly spherical in shape of irregular edges with little aggregations at different magnifications (Figure 2A, C, and D).…”

Section: Characterizations Of Tdnmentioning

confidence: 99%

<p>Comparative Study of Antibacterial Effects of Titanium Dioxide Nanoparticles Alone and in Combination with Antibiotics on MDR <em>Pseudomonas aeruginosa</em> Strains</p>

Ahmed¹,

Aly²,

El-Baky³

et al. 2020

IJN

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Introduction: The efficacy of several antimicrobial agents has been hindered due to the increasing frequency of multidrug-resistant (MDR) Pseudomonas aeruginosa strains. So, the need for new antibacterial drugs or drug combinations is urgent. Recently, desirable antibacterial effects were reported for many metals nanoparticles such as TiO 2 nanoparticles (TDNs). Purpose: This study aims to investigate the prevalence of MDR P. aeruginosa and assess the efficiency of TDN in the treatment of MDR P. aeruginosa-associated infections. Materials and Methods: The synthesis of TDN by the sol-gel method was carried out. Particle size measurements and morphology were done using dynamic light scattering (DLS) and high-resolution transmission electron microscopy (HR-TEM). To investigate the physical and chemical changes of drugs due to the combination, the tested drugs, both alone and in combination with TDN, were subjected to differential scanning calorimetry (DSC), infrared (IR) spectroscopy, and X-ray diffraction studies. Antimicrobial susceptibility was detected by agar disc-diffusion assay. The minimum inhibitory concentration (MIC) of TDN and the tested antibiotics were assessed by the agar dilution method. Checkerboard analysis was performed to determine the combined effect of TDN and the tested antibiotics against 25 MDR P. aeruginosa strains. Results: TDNs were prepared with an average particle size of 64.77 ± 0.14 nm with an accepted polydispersity index (PDI) value of 0.274 ± 0.004. TEM showed that the particles were shaped into irregular spheres. Twenty-five P. aeruginosa isolates that were absolutely resistant to cefepime (100%), highly resistant to ceftriaxone (96%), amikacin (80%), and ciprofloxacin (76%) were selected. Superior antibacterial activity of TDN was observed against the selected 25 MDR P. aeruginosa isolates. The combination of TDN and cefepime were found to show synergistic activity against all tested isolates followed by ceftriaxone (96%), amikacin (88%), and ciprofloxacin (80%). Conclusion: Using TDN in combination with antibiotics can help in the treatment of MDR P. aeruginosa-associated infections. So, preparation of topical pharmaceutical dosage forms containing a combination of these antibiotics and TDN can be useful against MDR P. aeruginosa.

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Electrospray deposition of titanium dioxide (TiO2) nanoparticles

Cited by 14 publications

References 7 publications

Photocatalytic Treatments for Personal Protective Equipment: Experimental Microbiological Investigations and Perspectives for the Enhancement of Antimicrobial Activity by Micrometric TiO2

Photocatalytic Treatments for Personal Protective Equipment: Experimental Microbiological Investigations and Perspectives for the Enhancement of Antimicrobial Activity by Micrometric TiO2

Microneedle Coating Techniques for Transdermal Drug Delivery

<p>Comparative Study of Antibacterial Effects of Titanium Dioxide Nanoparticles Alone and in Combination with Antibiotics on MDR <em>Pseudomonas aeruginosa</em> Strains</p>

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