Electrospray ionization mass spectrometry for analysis of low-molecular-weight anticancer drugs and their analogues

Abstract

In this study, several anticancer drugs and their analogues consisting of organic and organometallic compounds were analyzed by electrospray ionization mass spectrometry (ESI/MS) using a quadrupole mass spectrometer. Protonated molecular ions [M+H](+) were observed for all of the compounds studied, and in the case of the two steroid sulfates, deprotonated molecular ions [M-H](-) were obtained. Tandem mass spectrometry was performed on these quasimolecular ions, and the product ions formed provided useful fragmentation patterns that were characteristic for the compounds. This study provides evidence that ESI/MS is a sensitive technique for structure confirmation and identification of small organic and organometallic molecules.

Electrospray Ionization Mass Spectrometry of Palladium(II) Quinolinylaminophosphonate Complexes

“…In some cases, adducts with potassium ion were also detected. Addition of alkali cation was observed in ESI spectra of a number of amine-containing halide complexes of platinum(II) and palladium(II) and in complexes where a basic group (e.g., pyridinyl) is coordinated to the metal center [31][32][33][34]. Furthermore, in the spectra of all types of the investigated palladium complexes, a series of ions formed by addition of acetonitrile to some fragment ions could be seen.…”

Identification of photodegradants of droloxifene by combined HPLC--MS, NMR spectroscopy and computational chemistry

“…This behavior is identical with that reported for tamoxifen. 9 A number of different collision energy and collision gas density conditions were explored in a search for more useful CID conditions, without success.…”

Identification of Modified and Unmodified Lipophilic B-Diketones Using Electrospray Ionisation Mass Spectrum (Esi-Ms)

“…Literature report has it that, ESI-MS method is reliable, robust and much less time consuming than the GC methods [4]. Importantly, ESI-MS is simple, fast, accurate, sensitive and straightforward technique for the analyzing compounds [5,6]. Alternative techniques for analyses of compounds such as NMR need further processing and requisite expertise to enable the identification of a compound.…”