Electrospray ionization‐multistage tandem mass spectrometry of complex multitin organometallic compounds

Abstract

The series of 14 complex organotin(IV) compounds containing many tin atoms and noncovalent bonds in the structure was characterized by electrospray ionization multistage tandem mass spectrometry (ESI-MS(n)). The mass spectra were measured in both polarity modes to obtain complementary structural information. The characteristic pattern of ten natural tin isotopes allowed the determination of the number of tin atoms in the molecular adducts and fragment ions by comparing theoretical and experimental isotopic distributions. Positive ion ESI spectra show unusual adduct formation depending on the type of organic solvent used for the direct infusion analysis owing to the ion-molecule reactions in the ion source. On the basis of the detailed spectral interpretation of organotin(IV) compounds, the fragmentation patterns of multitin organometallic compounds have been proposed. Noncovalent bonds in polymeric complexes are fragmented first, which is then followed by characteristic neutral losses in monomeric units.

Synthesis and characterization of tributyltin derivatives from 4‐oxo‐4‐(arylamino)butanoic acids and their in vitrobiological activity against cervical cancer cell lines

“…Tin is the only element that has ten naturally occurring isotopes, and the mass spectra obtained for compounds 3a , 3b , 3c , 3d show the characteristic peak patterns of molecules containing one tin atom . The molecular ion peak in all derivatives is not observed, but the cleavage of butyl groups takes place with the successive loss of the second butyl group followed by the loss of the ligand.…”

New diorganotin(IV) complexes of Schiff base derived from 4‐amino‐3‐hydrazino‐5‐mercapto‐4H‐1,2,4‐triazole: Synthesis, structural characterization, density functional theory studies, atoms‐in‐molecules analysis and antifungal activity

“…The characteristic fragment ions along with their relative abundance and probable ion structure are presented in Section and also summarized in Tables S4 and S5. The m / z values discussed have been assigned on the basis of 120 Sn, which is the most abundant isotope of tin …”

Characterization of bis-carboxyethyl germanium sesquioxide and its complexes with amino acids using electrospray QqTOF mass spectrometry

“…1E The polyisotopic elements, such as Ge, Sn, Ni, have a characteristic distribution of isotopic peaks which helps in the interpretation of their mass spectra [18,19]. Therefore, the presence and exact number of germanium atoms in individual ions was verified by the comparison of experimental isotopic distributions with the theoretical ones.…”

“…One of the most suitable ones is mass spectrometry (MS) which can be coupled to liquidphase separation techniques for speciation analysis [16]. Another possibility, only applicable for pure compounds, is the use of direct infusion MS, which we have successfully applied for the characterization of organotin and organonickel compounds [17][18][19]. Only a few papers dealing with MS analysis of Ge-132 have been published so far [20][21][22][23].…”