Electrospray Mass Spectrometry of Iron Bleomycin II: Investigation of the Reaction of Fe(III)-Bleomycin with Iodosylbenzene

Sequence-specific Changes in the Metal Site of Ferric Bleomycin Induced by the Binding of DNA

“…Sample Preparation-Bleomycin A 2 was purified from bleomycin sulfate (Blenoxane; generously supplied by Bristol-Myers Co., Syracuse, NY) over a Source S fast protein liquid chromatography column (Amersham Pharmacia Biotech) as described previously (29). The purity of the BLM fractions was confirmed by mass spectrometry (30).…”

Online Monitoring of Polymerizations: Current Status

“…Sam and coworkers introduced the implementation of a low-volume mixing tee directly coupled to the ionization probe of an electrospray mass spectrometer. [65] A rapid reaction of ferric bleomycin (Fe III BLM) with iodosylbenzene (PhIO) was investigated by analysis of several cleavage products of the drug. The intermediate reaction products observed suggested a new reaction pathway that does not involve activated oxygen or hypervalent iron, but instead hypervalent iodine, I III , as the reactive species.…”

Study on the reactive transient α‐λ3‐iodanyl‐acetophenone complex in the iodine(III)/PhI(I) catalytic cycle of iodobenzene‐catalyzed α‐acetoxylation reaction of acetophenone by electrospray ionization tandem mass spectrometry

“…[1,2,8,9] These studies revealed the presence of some reactive hypervalent iodine species in the reaction solution. In 1995, Sam et al first used electrospray ionization mass spectrometry (ESI-MS) to study of oxidation reaction of PhIO in methanol [10] and they observed reactive l 3 [11] while Silva and co-workers studied the disproportionation reaction of DIB in acetonitrile and methanol by high-resolution ESI-MS/(MS). [12,13] In recent years, the catalytic hypervalent iodine oxidation reaction has been studied by using co-oxidants.…”