Electrospray particles as drug delivery systems

Thakkar, Shreya; Misra, Manju

doi:10.1016/b978-0-12-822476-2.00013-3

Cited by 3 publications

(2 citation statements)

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“…In the electrospray process, when the fluid exits the nozzle and enters the electric field, it forms a Taylor cone due to surface tension, and as the electric field increases, the Taylor cone turns into highly charged droplets 28 . This process enables the encapsulation of various drugs, vitamins, and proteins that can be used in targeted drug delivery systems 29–31 . Nano and microcapsules made of polycaprolactone (PCL) can be prepared using electrospray techniques for use in drug applications and growth factor release 32 .…”

Section: Introductionmentioning

confidence: 99%

“…28 This process enables the encapsulation of various drugs, vitamins, and proteins that can be used in targeted drug delivery systems. [29][30][31] Nano and microcapsules made of polycaprolactone (PCL) can be prepared using electrospray techniques for use in drug applications and growth factor release. 32 These capsules are good candidates due to their favorable properties.…”

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confidence: 99%

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Doxorubicin/poly(caprolactone)/polyethylene glycol nanoparticles prepared by electrospray

Mehrazin,

Asefnejad,

Naeimi

et al. 2023

Polymers for Advanced Techs

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The development of sustainable drug delivery systems is very important in the field of pharmaceutical research and has many advantages over the usual methods of drug administration, including improving effectiveness, reducing side effects, and increasing patient compliance. Among various techniques, electrospraying as a voltage‐driven process has emerged as a promising technology for the fabrication of drug‐loaded nanoparticles. In recent years, the application of electrospray approach for drug release has been widely investigated. However, optimization of electrospray process parameters and development of mathematical models to predict drug release kinetics from microparticles are still challenging. To address these issues, a combination of Central Composite Design (CCD) and Response Surface Methodology (RSM) has been used. This paper focuses on the application of CCD‐RSM for modeling and optimization of doxorubicin (DOX)‐poly(caprolactone) (PCL)‐polyethylene glycol (PEG) microparticles prepared using electrospray method. Doxorubicin, a widely used anticancer drug, exhibits potent cytotoxicity against a wide range of cancers. PCL‐PEG microparticles are promising as drug carriers due to their biocompatibility, controlled release properties, and ability to protect the encapsulated drug from degradation. The CCD‐RSM approach allows systematic investigation and optimization of several formulation and process variables, including polymer concentration, PCL‐PEG weight ratio, and applied voltage on drug release behavior. In addition, the effect of rheology and electrical conductivity of polymer fluid on the size of particles obtained from electrospraying was investigated. The effect of adding folic acid and doxorubicin in the optimized sample of nanoparticles and the effect of different concentrations of doxorubicin were investigated, and SEM, DLS, and FTIR techniques were used to characterize the microparticles, and the MMT test was performed to evaluate their cytotoxicity. The results showed that the optimized formulation is effective for sustained drug release over a long period for drug delivery applications.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Doxorubicin/poly(caprolactone)/polyethylene glycol nanoparticles prepared by electrospray

Mehrazin,

Asefnejad,

Naeimi

et al. 2023

Polymers for Advanced Techs

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Pulsed coaxial drop-on-demand electrohydrodynamic printing

et al. 2023

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This research demonstrates pulsed electrohydrodynamic drop-on-demand (DoD) printing as a novel technique for synthesizing core-shell microparticles in a controlled manner. In this regard, a multiphase and multiphysics model is presented for coaxial electrohydrodynamic printing. The governing partial differential equations of the model are discretized using the finite element method, and a suitable numerical scheme is adopted to solve the system of discretized equations. The experimental results in the literature are used to validate the numerical model. Utilizing the validated model, the effects of continuous-direct current (DC) voltage and pulsed-DC voltage are examined on the behavior of a compound meniscus (composed of ethylene glycol core and olive oil shell) and the droplet formation process. According to the results obtained, the onset voltage of the compound meniscus is 3330 V, which agrees with the scale analysis. Furthermore, increasing continuous-DC voltage results in longer breakup length, shorter breakup time, faster droplet velocity, and shorter jetting start time. In addition, increasing pulsed-DC voltage duration leads to an increase in the breakup length and droplet velocity. Most importantly, it is possible to control the inertia of the coaxial spindle by controlling the pulsed-DC voltage magnitude and duration to ensure that a core-shell droplet separates from the meniscus in every pulse with the shortest breakup length and the minimum satellite droplets possible. It is generally recommended to keep the pulse duration and amplitude low enough to prevent long breakup length and irregularities in the printed pattern; however, they must be sufficiently large to sustain micro-dripping mode.

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