Electrosprayed nanoparticles for drug delivery and pharmaceutical applications

Abstract

Nanotechnology based Pharma has emerged significantly and has influenced the Pharma industry up to a considerable extent. Nanoparticles technology holds a good share of the nanotech Pharma and is significant in comparison with the other domains. Electrospraying technology answers the potential needs of nanoparticle production such as scalability, reproducibility, effective encapsulation etc. Many drugs have been electrosprayed with and without polymer carriers. Drug release characteristics are improved with the incorporation of biodegradable polymer carriers which sustain the release of encapsulated drug. Electrospraying is acknowledged as an important technique for the preparation of nanoparticles with respect to pharmaceutical applications. Herein we attempted to consolidate the reports pertaining to electrospraying and their corresponding therapeutic application area.

Chitosan Microgels and Nanoparticles via Electrofluidodynamic Techniques for Biomedical Applications

“…In this context, chemical synthesis-i.e., monomer polymerization in solution-or physical assembly based on electrostatic interactions among polymer chains (i.e., coacervation) [18] or ionic gelation [19] have been often dropped for the use of organic solvents of chemical agents, being potentially hazardous to the environment as well as to physiological systems. More recently, novel technologies based on supercritical fluids have been also considered for their eco-sustainability and suitability for mass production, although several shortfalls mainly associated to production methods, high cost and increasing complexity of equipment [20]. Thanks to recent discoveries in nanotechnologies, it is possible to finely manipulate particle size and surface properties at micro and sub-micrometric scale for different applicative demands.…”

“…CHI solutions are processed via electrospraying (NANON01, MECC, JAPAN) by properly setting process parameters to obtain sub-micrometric round-like particles. The polymer solution is placed in a 5 mL syringe and is continuously pushed by the syringe pump at several flow rates (0.1-0.3 mL/h) using a steel nozzle (18)(19)(20)(21)(22)(23)(24)(25)(26)(27) which is connected to the high-voltage power supply to generate a potential difference (13-28 kV) between nozzle and ground collector. Lastly, nozzle/collector distance is fixed between 7 to 10 cm to prevent clogging phenomena at the needle tip due to fast solvent evaporation.…”

Controlled release of drugs in electrosprayed nanoparticles for bone tissue engineering

“…The size, structure and surface area to volume ratio of nanoparticles are inter-related to the biological activity and functionalization. Nanoparticle research is therefore an area of great scientific attention due to its potential applications in tissue engineering and many research articles (>1000) related to regenerative medicine which have been published over the past few decades [2].…”

Improved shellac mediated nanoscale application drug release effect in a gastric-site drug delivery system

“…The main aim of the nano-formulations is to adjust the normal metabolic prole of proven established drug molecules by signicantly improving the drug efficacy, sustaining release and reducing side effects simultaneously. 15 Nanotechnology applications based on DDSs include nanoemulsions, nanoparticles, liposomes and nanobers. Nanoproduct drug delivery systems (DDSs) have the advantages of lower cost, scalability, targeted delivery, reduced side effects, biodegradability, biocompatibility, sustainability in release of encapsulated drug and improved efficacy.…”