Electrospraying an enabling technology for pharmaceutical and biomedical applications: A review

Boda, Sunil Kumar; Li, Xiaoran; Xie, Jingwei

doi:10.1016/j.jaerosci.2018.04.002

Cited by 144 publications

(107 citation statements)

References 100 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…Electrospraying technique allows us to obtain particles with sizes less than 100 nm. An advantage of the electrospraying technique is the application of voltage, which charges the polymer solution, breaking the surface tension of the same, forming smaller diameters and more spherical particles (Boda, Li, & Xie, ; Jaworek & Sobczyk, ; Tapia‐Hernández et al., ). When the concentration of a bioactive compound increases in zein nanoparticles, the particle size increases.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

Rodríguez-Félix

Del‐Toro‐Sánchez

Cinco-Moroyoqui

et al. 2019

Journal of Food Science

View full text Add to dashboard Cite

Quercetin is a hydrophobic flavonoid with high antioxidant activity. However, for biological applications, the bioavailability of quercetin is low due to physiological barriers. For this reason, an alternative is the protection of quercetin in matrices of biopolymers as zein. The objective of this work was to prepare and characterize quercetin‐loaded zein nanoparticles by electrospraying and its study of in vitro bioavailability. The physicochemical parameters such as viscosity, density, and electrical conductivity of zein solutions showed a dependence of the ethanol concentration. In addition, rheological parameters demonstrated that solutions of zein in aqueous ethanol present Newtonian behavior, rebounding in the formation of nanoparticles by electrospraying, providing spherical, homogeneous, and compact morphologies, mainly at a concentration of 80% (v/v) of ethanol and of 5% (w/v) of zein. The size and shape of quercetin‐loaded zein nanoparticles were studied by transmission electron microscopy (TEM), observing that it was entrapped, distributed throughout the nanoparticle of zein. Analysis by Fourier transform‐infrared (FT‐IR) of zein nanoparticles loaded with quercetin revealed interactions via hydrogen bonds. The efficacy of zein nanoparticles to entrap quercetin was particularly high for all quercetin concentration evaluated in this work (87.9 ± 1.5% to 93.0 ± 2.6%). The in vitro gastrointestinal release of trapped quercetin after 240 min was 79.1%, while that for free quercetin was 99.2%. The in vitro bioavailability was higher for trapped quercetin (5.9%) compared to free quercetin (1.9%), than of gastrointestinal digestion. It is concluded, that the electrospraying technique made possible the obtention of quercitin‐loaded zein nanoparticles increasing their bioavailability. Practical Application This type of nanosystems can be used in the food and pharmaceutical industry. Quercetin‐loaded zein nanoparticles for its improvement compared to free quercetin can be used to decrease the prevalence of chronic degenerative diseases by increasing of the bioavailability of quercetin in the bloodstream. Other application can be as an antioxidant system in functional foods or oils to increase shelf life.

show abstract

Section: Resultsmentioning

confidence: 99%

“…. diameters and more spherical particles (Boda, Li, & Xie, 2018;Jaworek & Sobczyk, 2008;Tapia-Hernández et al, 2015). When the concentration of a bioactive compound increases in zein nanoparticles, the particle size increases.…”

Section: Food Engineering Materials Science and Nanotechnologymentioning

confidence: 99%

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

Rodríguez-Félix

Del‐Toro‐Sánchez

Cinco-Moroyoqui

et al. 2019

Journal of Food Science

View full text Add to dashboard Cite

show abstract

“…Figure presents GA‐loaded zein nanoparticles obtained at high (15 kV) and low (10 kV) voltage. At high voltage values, it aids in obtaining a smaller particle diameter with spherical morphology and one that is more monodispersed, unlike low voltage, with irregular morphology and polydispersity (Boda et al., ). A similar study was carried out by Baspinar, Üstündas, Bayraktar, and Sezgin (), who elaborated zein and curcumin‐loaded zein nanoparticles and evaluated the effect of voltage on morphology and particle size.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, on one hand, the single‐fluid electrospraying and electrospinning are still the mainstreams of these fabrication methods. On the other hand, the fundamental investigations about the influences of operational parameters on the processes and also the quality of resultant products are high desired (Wang et al., 2017; Boda, Li, & Xie, ; Li, Yang, Yu, Du, & Yang, ). Specifically, in electrospraying process, different biopolymers have been utilized for the elaboration of nanoparticles, such as polysaccharides (Eltayeb, Stride, & Edirisinghe, ; Sreekumar, Lemke, Moerschbacher, Torres‐Giner, & Lagaron, ), lipids (Liu, Li, Williams, Wu, & Zhu, ), and proteins (Gómez‐Estaca, Gavara, & Hernández‐Muñoz, ; Gómez‐Mascaraque, Tordera, Fabra, Martínez‐Sanz, & Lopez‐Rubio, ).…”

Section: Introductionmentioning

confidence: 99%

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

Tapia-Hernández

Del‐Toro‐Sánchez

Cinco-Moroyoqui

et al. 2019

Journal of Food Science

View full text Add to dashboard Cite

Currently, electrospraying is a novel process for obtaining the nanoparticles from biopolymers. Zein nanoparticles have been obtained by this method and used to protect both hydrophilic and hydrophobic antioxidant molecules from environmental factors. The objective of this work was to prepare and characterize gallic acid‐loaded zein nanoparticles obtained by the electrospraying process to provide protection to gallic acid from environmental factors. Thus, it was related to the concentration of gallic acid in physicochemical and rheological properties of the electrosprayed solution, and also to equipment parameters, such as voltage, flow rate, and distance of the collector in morphology, and particle size. The physicochemical properties showed a relationship in the formation of a Taylor cone, in which at a low concentration of gallic acid (1% w/v), low viscosity (0.00464 ± 0.00001 Pa·s), and density (0.886 ± 0.00002 g/cm3), as well as high electrical conductivity (369 ± 4.3 µs/cm), forms a stable cone‐jet mode. The rheological properties and the Power Law model of the gallic acid‐zein electrosprayed solution demonstrated Newtonian behavior (n = 1). The morphology and size of the particle were dependent on the concentration of gallic acid. Electrosprayed parameters with high voltage (15 kV), low flow rate (0.1 mL/hr), and short distance (10 cm) exhibited a smaller diameter and spherical morphology. FT–IR showed interaction in the gallic acid‐loaded zein nanoparticle by hydrogen bonds. Therefore, the electrospraying process is a feasible technique for obtaining gallic acid‐loaded zein nanoparticles and providing potential protection to gallic acid from environmental factors.

show abstract

“…The electrostatic force incurred by these charges surmounts the surface tension of the solution and splits the solution jet into very small droplets. Tiny droplets with charges resist one another and droplet consolidation can be minimized, which in turn produces droplets with a uniform size distribution [3].…”

Section: Introductionmentioning

confidence: 99%

An Orthogonal Model to Study the Effect of Electrospraying Parameters on the Morphology of poly (d,l)-lactide-co-glycolide (PLGA) Particles

et al. 2019

View full text Add to dashboard Cite

Electrospraying has been recognized as an important technique for the production of microparticles for pharmaceutical applications. Nevertheless, the produce of poly (d,l)-lactide-co-glycolide (PLGA) microspheres with a desired size distribution remains a challenge. We conducted an empirical study, based on a fractional orthogonal design, to optimize the size distribution of electrosprayed particles. The influence of different processing factors, including PLGA concentration in the solution, volumetric flow rate of the solution, travel distance between the needle tip and the collection, voltage applied to the polymer solution, size of the needle, and type of solvent on the electrospraying of polymeric microparticles was investigated. After electrospraying, the size distribution of the PLGA particles was characterized and analyzed. Among the selected factors, the type of solvent used was the principal factor affecting the particle size of electrosprayed microspheres. Hexafluoro-2-propanol (HFIP) electrosprayed microparticles with the smallest diameter. However, hollowed particles could be seen among these microspheres. Dichloromethane (DCM) was found to electrospray microspheres with a fairly spherical geometry, while trichloromethane (TCM) electrosprayed particles with relatively rougher surfaces. Finally, the particle size of sprayed microspheres decreases somewhat with the polymer concentration and travel distance.with electrospraying, nevertheless, the optimization of the spraying procedure has been based on a time-consuming trial-and-error process.In past three decades, PLGA has been one of the most attractive polymeric materials used to manufacture devices for drug delivery and tissue engineering applications [15]. PLGA is biocompatible and biodegradable, possesses a wide range of erosion times, has tunable mechanical strengths, and most importantly, is a FDA approved polymer. Crystalline PGA, when co-polymerized with PLA, reduces the degree of crystallinity of PLGA, and as a result, increases the rate of hydration and hydrolysis. As a rule, a higher content of PGA leads to quicker rates of degradation, with an exception of 50:50 ratio of PLA/PGA, which exhibits the fastest degradation. A ratio of 50:50 PLGAs have been extensively studied for the development of devices for controlled delivery of small molecule drugs, proteins and other macromolecules in commercial use and in research [16].An empirical study, based on a fractional orthogonal array design, was completed to investigate the effect of different processing factors on the size distribution of electrosprayed particles. 50:50 PLGA materials were selected. Experiments were carried out on an electrospraying setup consisting of a syringe and needle, a ground electrode, and a high voltage supply. After electrospraying, the particle size and morphology were characterized by a scanning electron microscope. A fractional orthogonal was designed based on a design matrix proposed by Dr. Genichi Taguchi [17]. It allows one to examine a selected subset of combin...

show abstract

Electrospraying an enabling technology for pharmaceutical and biomedical applications: A review

Cited by 144 publications

References 100 publications

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

Preparation and Characterization of Quercetin‐Loaded Zein Nanoparticles by Electrospraying and Study of In Vitro Bioavailability

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

An Orthogonal Model to Study the Effect of Electrospraying Parameters on the Morphology of poly (d,l)-lactide-co-glycolide (PLGA) Particles

Contact Info

Product

Resources

About