Electrospun Aligned Coaxial Nanofibrous Scaffold for Cardiac Repair

Sridharan, Divya; Palaniappan, Arunkumar; Blackstone, Britani N.; Powell, Heather M.; Khan, Mahmood

doi:10.1007/978-1-0716-0845-6_13

Cited by 15 publications

(22 citation statements)

References 11 publications

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“…Others have proposed aligned coaxial nanofiber as a scaffold to mimic the ECM heart structure to seed hiPSC-CMs. CMs aligned themselves with the nanofibrous structure and assumed an elongated morphology, resembling the in vivo morphology of adult CMs (Ding et al, 2020;Sridharan et al, 2021). The nanofibers may be natural materials (gelatin, collagen, fibrin) or synthetic polymers (PCL).…”

Section: Scaffold-based Heart Modelsmentioning

confidence: 94%

Cardiac tissue engineering: Multiple approaches and potential applications

Gisone

Cecchettini

Ceccherini

et al. 2022

Front. Bioeng. Biotechnol.

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The overall increase in cardiovascular diseases and, specifically, the ever-rising exposure to cardiotoxic compounds has greatly increased in vivo animal testing; however, mainly due to ethical concerns related to experimental animal models, there is a strong interest in new in vitro models focused on the human heart. In recent years, human pluripotent stem cells-derived cardiomyocytes (hiPSC-CMs) emerged as reference cell systems for cardiac studies due to their biological similarity to primary CMs, the flexibility in cell culture protocols, and the capability to be amplified several times. Furthermore, the ability to be genetically reprogrammed makes patient-derived hiPSCs, a source for studies on personalized medicine. In this mini-review, the different models used for in vitro cardiac studies will be described, and their pros and cons analyzed to help researchers choose the best fitting model for their studies. Particular attention will be paid to hiPSC-CMs and three-dimensional (3D) systems since they can mimic the cytoarchitecture of the human heart, reproducing its morphological, biochemical, and mechanical features. The advantages of 3D in vitro heart models compared to traditional 2D cell cultures will be discussed, and the differences between scaffold-free and scaffold-based systems will also be spotlighted.

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Section: Scaffold-based Heart Modelsmentioning

confidence: 94%

Cardiac tissue engineering: Multiple approaches and potential applications

Gisone

Cecchettini

Ceccherini

et al. 2022

Front. Bioeng. Biotechnol.

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“…We may try to do the combination of electrospinning with nanofiber hydrogels (66) to improve their mechanical properties. We can also continue to develop more 3D printed scaffolds as templates to promote cardiomyocyte infiltration (67).…”

Section: Potential Development Direction Of Electrospinningmentioning

confidence: 99%

New Forms of Electrospun Nanofibers Applied in Cardiovascular Field

Huang

Huo

Cheng

et al. 2022

Front. Cardiovasc. Med.

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Cardiovascular disease (CVD) is one of the leading causes of death worldwide. In recent years, regenerative medicine, tissue engineering and the development of new materials have become the focus of attention this field, and electrospinning technology to prepare nanofibrous materials for the treatment of cardiovascular diseases has attracted people's attention. Unlike previous reviews, this research enumerates the experimental methods and applications of electrospinning technology combined with nanofibrous materials in the directions of myocardial infarction repair, artificial heart valves, artificial blood vessels and cardiovascular patches from the perspective of cardiovascular surgery. In the end, this review also summarizes the limitations, unresolved technical challenges, and possible future directions of this technology for cardiovascular disease applications.

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“…Moreover, the embedding hydrogel made neurites extend along and above the scaffolds in multiple layers, compared to scaffolds alone [ 154 , 155 ]. Another example reported the electrospinning of a polyaniline-gelatin-polycaprolactone (PANi-GEL-PCL) nanoscaffold superficially modified by plasma method for bone tissue engineering [ 157 ], but also for bone regeneration [ 158 ], cardiac repair and diabetes [ 159 , 160 ] and aneurysm modeling [ 161 ].…”

Section: Nanostructured Biomaterialsmentioning

confidence: 99%

Advanced Multi-Dimensional Cellular Models as Emerging Reality to Reproduce In Vitro the Human Body Complexity

Bassi

Grimaudo

Panseri

et al. 2021

IJMS

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A hot topic in biomedical science is the implementation of more predictive in vitro models of human tissues to significantly improve the knowledge of physiological or pathological process, drugs discovery and screening. Bidimensional (2D) culture systems still represent good high-throughput options for basic research. Unfortunately, these systems are not able to recapitulate the in vivo three-dimensional (3D) environment of native tissues, resulting in a poor in vitro–in vivo translation. In addition, intra-species differences limited the use of animal data for predicting human responses, increasing in vivo preclinical failures and ethical concerns. Dealing with these challenges, in vitro 3D technological approaches were recently bioengineered as promising platforms able to closely capture the complexity of in vivo normal/pathological tissues. Potentially, such systems could resemble tissue-specific extracellular matrix (ECM), cell–cell and cell–ECM interactions and specific cell biological responses to mechanical and physical/chemical properties of the matrix. In this context, this review presents the state of the art of the most advanced progresses of the last years. A special attention to the emerging technologies for the development of human 3D disease-relevant and physiological models, varying from cell self-assembly (i.e., multicellular spheroids and organoids) to the use of biomaterials and microfluidic devices has been given.

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Electrospun Aligned Coaxial Nanofibrous Scaffold for Cardiac Repair

Cited by 15 publications

References 11 publications

Cardiac tissue engineering: Multiple approaches and potential applications

Cardiac tissue engineering: Multiple approaches and potential applications

New Forms of Electrospun Nanofibers Applied in Cardiovascular Field

Advanced Multi-Dimensional Cellular Models as Emerging Reality to Reproduce In Vitro the Human Body Complexity

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