Electrospun and co-electrospun biopolymer nanofibers for skin wounds on diabetic patients: an overview

Campa-Siqueiros, Paola I.; Madera‐Santana, Tomás J.; Castillo‐Ortega, M. M.; López‐Cervantes, Jaime; Ayala‐Zavala, J. Fernando; Ortiz-Vázquez, Elizabeth

doi:10.1039/d1ra02986j

Cited by 26 publications

(10 citation statements)

References 84 publications

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“…[11][12][13][14][15][16][17] These aspects highlight the immense need for a therapeutic dressing material possessing multifaceted properties. [18][19][20] A plethora of literature is available on wound-care materials based on the intended application, such as antimicrobial, debridement, absorbent, or occlusive. [21] Recently, substantial importance has been given to dressing materials that mimic the function of the extracellular matrix, which facilitates the migration and proliferation of dermal and epidermal cells for effective wound closure.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication and Facile Surface Derivatization of Poly(ε‐caprolactone)‐Based Wound Dressing Materials Imparting Anti‐Infective, Excessive Biofluid Drainage, and Easy‐to‐Peel Characteristics

Mude

Tata

Trinath

et al. 2023

Advanced Therapeutics

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The rapid emergence of antimicrobial resistance warrants an antibiotic‐free approach to counter the bacterial threat in all possible applications of environmental and biomedical domains. In the context of smart wound dressing, besides imparting anti‐infective characteristics in a nonconventional fashion, it is also essential to imbibe multifunctional attributes like excessive biofluid drainage, easy‐to‐peel, optimal gas permeation, etc., for which appropriate material design is a prime requisite. In this work, poly(ε‐caprolactone) (PCL)− an FDA approved biocompatible polyester− is chosen for imparting antimicrobial properties by surface derivatization with molecularly‐dispersed ionic silver over quaternary ammonium moieties through a facile room temperate and organic solvent‐free approach. To render the other characteristics mentioned above, two different systems comprising PCL with varying porosity, namely, electrospun fibers and polyester‐coated cotton gauze, are developed. The dressing materials are thoroughly characterized and assessed for their structural, surface chemical, morphological, wettability, antibacterial, and peel strength properties as a function of surface derivatization steps. The bactericidal performance of the quaternary ammonium‐functionalized surfaces has enhanced manifold (≈7–10) after derivatizing with ionic silver. The in vivo efficacy study employing the dressing materials reveals ionic silver derivatized electrospun fibers as the most promising candidate, followed by cotton gauze‐coated with 5% PCL.

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Section: Introductionmentioning

confidence: 99%

“…[ 11–17 ] These aspects highlight the immense need for a therapeutic dressing material possessing multifaceted properties. [ 18–20 ]…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Facile Surface Derivatization of Poly(ε‐caprolactone)‐Based Wound Dressing Materials Imparting Anti‐Infective, Excessive Biofluid Drainage, and Easy‐to‐Peel Characteristics

Mude

Tata

Trinath

et al. 2023

Advanced Therapeutics

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“…All the membranes showed well-organized topological structures, with ellipsoidal-shaped nanopores, which were arranged with the major axis along the fiber direction. Co-electrospinning method, also known as coaxial electrospinning, is a method derived from electrospinning, the difference being that in the case of co-electrospinning, two needles are used instead of one needle, which makes it possible to obtain a core-shell nanofiber [ 122 ]. Al-Badani et al [ 123 ] reported a possible polycaprolactone/gelatin membrane as a tunable drug delivery system for bone tissue regeneration via co-electrospinning ( Figure 3 ).…”

Section: Biomedical Applications Of Membranesmentioning

confidence: 99%

Polymeric Membranes for Biomedical Applications

2023

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Polymeric membranes are selective materials used in a wide range of applications that require separation processes, from water filtration and purification to industrial separations. Because of these materials’ remarkable properties, namely, selectivity, membranes are also used in a wide range of biomedical applications that require separations. Considering the fact that most organs (apart from the heart and brain) have separation processes associated with the physiological function (kidneys, lungs, intestines, stomach, etc.), technological solutions have been developed to replace the function of these organs with the help of polymer membranes. This review presents the main biomedical applications of polymer membranes, such as hemodialysis (for chronic kidney disease), membrane-based artificial oxygenators (for artificial lung), artificial liver, artificial pancreas, and membranes for osseointegration and drug delivery systems based on membranes.

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“…Synthetic polymers have made great progress in the preparation of wound dressings alone, and they are commonly used as scaffolds for drug encapsulation and delivery, 70 but their inherent disadvantages limit their further development and application. For example, the nanofibers made from PVA have poor thermal stability and strength 71 ; the electrospinning nanofiber films made from PCL and PLA have high hydrophobicity and lack of cell binding sites, 72 which limit their application in wound dressings. Meanwhile, synthetic polymer nanofibers achieve structural programming, but they lack the necessary biological functions, such as biocompatibility and low cytotoxicity.…”

Section: Electrospinning Wound Dressing Of Synthetic Polymersmentioning

confidence: 99%

Advances in wound dressing based on electrospinning nanofibers

Zhang,

Wang,

Gao

et al. 2023

J of Applied Polymer Sci

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In recent years, there has been a significant focus on bioactive dressings suitable for treating chronic and acute wounds. Electrospinning nanofibers are considered advanced dressing options due to their high porosity and permeability to air and water, effective barrier properties against external pathogens, and excellent resemblance to the extracellular matrix for wound healing and skin regeneration. This article reviews the recent advancements in the application of electrospinning nanofibers for bioactive wound healing. The review begins with an overview of the wound healing process and electrospinning methods. It then explores the advantages and disadvantages of different synthetic and natural polymers used in the preparation of electrospinning wound dressings. The natural polymers discussed in this review include collagen, gelatin, silk fibroin, chitosan, hyaluronic acid, and sodium alginate. Additionally, the review delves into commonly used synthetic polymers like polyvinyl alcohol, polyvinyl chloride, polyethylene lactone, polylactide, and polyurethane for wound dressing applications. Furthermore, the review examines the blending of natural and synthetic polymers to create high‐performance wound dressings. It also explores the incorporation of functional additives, such as antimicrobial agents, growth factors, and natural extracts, into electrospinning nanofibers to expedite wound healing and tissue repair. In conclusion, electrospinning is an emerging technology that provides unique opportunities for designing more effective wound dressings and care products.

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Electrospun and co-electrospun biopolymer nanofibers for skin wounds on diabetic patients: an overview

Abstract: Wound healing treatment in diabetic patients worldwide represents around 2.1 trillion dollars to global health sectors.

Cited by 26 publications

References 84 publications

Fabrication and Facile Surface Derivatization of Poly(ε‐caprolactone)‐Based Wound Dressing Materials Imparting Anti‐Infective, Excessive Biofluid Drainage, and Easy‐to‐Peel Characteristics

Fabrication and Facile Surface Derivatization of Poly(ε‐caprolactone)‐Based Wound Dressing Materials Imparting Anti‐Infective, Excessive Biofluid Drainage, and Easy‐to‐Peel Characteristics

Polymeric Membranes for Biomedical Applications

Advances in wound dressing based on electrospinning nanofibers

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