Electrospun Biodegradable Nanofibrous Mats for Tissue Engineering

Ndreu, Albana; Nikkola, L.; Ylikauppila, Hanna; Ashammakhi, Nureddin; Hasırcı, Vasıf

doi:10.2217/17435889.3.1.45

Cited by 59 publications

(42 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The PHBV is a material with suitable properties for cellular growth and adhesion with controllable degradation (Meng et al, 2007;Dreu et al, 2008;Li & Xia, 2004). Nanofi bers have improved the performance of biomaterials.…”

Section: Introductionmentioning

confidence: 99%

Behavioral evaluation of regenerated rat sciatic nerve by a nanofibrous PHBV conduit filled with Schwann cells as artificial nerve graft

Biazar

Keshel

Pouya

2013

Cell Communication & Adhesion

View full text Add to dashboard Cite

The aim of this study is to develop a nanofi brous polymeric nerve conduit with Schwann cells (SCs) and to evaluate its effi ciency on the promotion of functional and locomotive activities in rats. The conduits were implanted into a 30-mm gap in the sciatic nerves of the rats. Four months after surgery, the rats were monitored and evaluated by behavioral analyses such as toe out angle, toe spreading analysis, walking track analysis, extensor postural thrust, open-fi eld analysis, swimming test and nociceptive function, four months post surgery. Four months post-operatively, the results from behavioral analyses demonstrated that in the grafted groups especially in the grafted group with SCs, the rat sciatic nerve trunk had been reconstructed with functional recovery such as walking, swimming and recovery of nociceptive function. This study proves the feasibility of artifi cial conduit with SCs for nerve regeneration by bridging a longer defect in the rat model.

show abstract

Section: Introductionmentioning

confidence: 99%

Behavioral evaluation of regenerated rat sciatic nerve by a nanofibrous PHBV conduit filled with Schwann cells as artificial nerve graft

Biazar

Keshel

Pouya

2013

Cell Communication & Adhesion

View full text Add to dashboard Cite

show abstract

“…We have also observed the effect of this salt on e-spun PHBV-8 fiber morphology. 82 PHBV-8 fiber structure that was produced from solutions containing no salt had resulted in bead formation and fibers were not straight. When salt was added, bead formation was prevented and more straight fibers were obtained 82 86 (Fig.…”

mentioning

confidence: 99%

Biodegradable Nanomats Produced by Electrospinning: Expanding Multifunctionality and Potential for Tissue Engineering

Ashammakhi

Ndreu²,

Piras³

et al. 2007

j nanosci nanotechnol

View full text Add to dashboard Cite

With increasing interest in nanotechnology, development of nanofibers (n-fibers) by using the technique of electrospinning is gaining new momentum. Among important potential applications of n-fiber-based structures, scaffolds for tissue-engineering represent an advancing front. Nanoscaffolds (n-scaffolds) are closer to natural extracellular matrix (ECM) and its nanoscale fibrous structure. Although the technique of electrospinning is relatively old, various improvements have been made in the last decades to explore the spinning of submicron fibers from biodegradable polymers and to develop also multifunctional drug-releasing and bioactive scaffolds. Various factors can affect the properties of resulting nanostructures that can be classified into three main categories, namely: (1) Substrate related, (2) Apparatus related, and (3) Environment related factors. Developed n-scaffolds were tested for their cytocompatibility using different cell models and were seeded with cells for to develop tissue engineering constructs. Most importantly, studies have looked at the potential of using n-scaffolds for the development of blood vessels. There is a large area ahead for further applications and development of the field. For instance, multifunctional scaffolds that can be used as controlled delivery system do have a potential and have yet to be investigated for engineering of various tissues. So far, in vivo data on n-scaffolds are scarce, but in future reports are expected to emerge. With the convergence of the fields of nanotechnology, drug release and tissue engineering, new solutions could be found for the current limitations of tissue engineering scaffolds, which may enhance their functionality upon in vivo implantation. In this paper electrospinning process, factors affecting it, used polymers, developed n-scaffolds and their characterization are reviewed with focus on application in tissue engineering.

show abstract

“…The relative fiber diameters of the blended polymers were ranked as following: PLA > PLA/PCL (7/3) > PLA/PCL (5/5) > PLA/PCL (3/7) > PCL. Many studies have reported that fibrous membranes blended with different biodegradable polymers by an electrospinning technique resulted in a range of diameter distributions from 10 nm to a few micrometer [11,12].…”

Section: Discussionmentioning

confidence: 99%

Bone regeneration potential of sub-microfibrous membranes with osteogenic induction of rBMSC for tissue engineering

Rhee¹,

Oh²,

Lim³

et al. 2017

Trop. J. Pharm Res

View full text Add to dashboard Cite

show abstract

Electrospun Biodegradable Nanofibrous Mats for Tissue Engineering

Cited by 59 publications

References 47 publications

Behavioral evaluation of regenerated rat sciatic nerve by a nanofibrous PHBV conduit filled with Schwann cells as artificial nerve graft

Behavioral evaluation of regenerated rat sciatic nerve by a nanofibrous PHBV conduit filled with Schwann cells as artificial nerve graft

Biodegradable Nanomats Produced by Electrospinning: Expanding Multifunctionality and Potential for Tissue Engineering

Bone regeneration potential of sub-microfibrous membranes with osteogenic induction of rBMSC for tissue engineering

Contact Info

Product

Resources

About