Electrospun Biopolyesters: Hydrophobic Scaffolds with Favorable Biological Response

Azari, Pedram; Hosseini, Samira; Murphy, Belinda; Martínez-Chapa, Sergio O.

doi:10.14302/issn.2641-4538.jphi-18-1975

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…[52,56] Moderately hydrophilizing a hydrophobic surface, such as PCL, can alter the surface energy of the biomaterial improving the adsorption of surface-related proteins and the diffusion of nutrients, which can lead to optimal adhesion, increased cellular infiltration, and tissue in-growth in a wounded area. [57] The contact angles (CA) were determined for each binary, trinary, and PCL scaffold to investigate the effect that PGS and SF can have on the hydrophobicity of PCL (Figure 6). Figure S2 presents the contact angle values for each group examined upon a 5 µL droplet settling at the surface of the electrospun mats over time, and significant differences among the groups examined.…”

Section: Wettabilitymentioning

confidence: 99%

High-throughput production of silk fibroin-based electrospun fibers as biomaterial for skin tissue engineering applications

Keirouz

Zakharova

Kwon

et al. 2020

Materials Science and Engineering: C

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In this work, a nozzle-free electrospinning device was developed to obtain high-throughput production of silk fibroin-based trinary biocompatible composite fibers with tunable wettability. Synthetic fiber materials tend to present suboptimal cell growth and proliferation, with many studies linking this phenomenon to the hydrophobicity of such surfaces. In this study, electrospun mats consisting of Poly(caprolactone) blended with variant forms of Poly(glycerol sebacate) and regenerated silk fibroin were fabricated. The main aim of this work was the development of fiber mats with tunable hydrophobicity/hydrophilicity properties depending on the variant curing forms and concentration of PGS. A variation of the conventional protocol used for the extraction of silk fibroin from Bombyx mori cocoons was employed, achieving significantly increased yields of the protein, in a third of the time required via the conventional protocol. The wettability of the scaffolds could be modulated varying the ratios and curing time of the PGS within the composite fibers. The trinary composite biomaterial presented good in vitro fibroblast attachment behavior and optimal growth, indicating the potential of such constructs towards the development of an artificial skin-like platform that can aid skin regeneration.

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Section: Wettabilitymentioning

confidence: 99%

High-throughput production of silk fibroin-based electrospun fibers as biomaterial for skin tissue engineering applications

Keirouz

Zakharova

Kwon

et al. 2020

Materials Science and Engineering: C

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“…While for scaffolding applications it is critically important to maintain the porous structure of paper upon the addition of polymer [19], some of the modification methods involve use of heat or chemicals that might damage paper’s natural fibrous microstructure. Furthermore, the pore size and fiber diameter of paper are far bigger than natural extracellular matrices (ECM), which is an interwoven random fibrous structure primarily made of proteins (mainly collagen and elastin), proteoglycans, and glycosaminoglycans [20,21]. ECM plays a crucial role in providing support for cell attachment and growth as well as serving as a reservoir of water, nutrients, cytokines, and growth factors for maintenance of tissue homeostasis [20].…”

Section: Introductionmentioning

confidence: 99%

Electrospin-Coating of Paper: A Natural Extracellular Matrix Inspired Design of Scaffold

Azari

Nam

et al. 2019

Polymers

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Paper has recently found widespread applications in biomedical fields, especially as an alternative scaffolding material for cell cultures, owing to properties such as its fibrous nature, porosity and flexibility. However, paper on its own is not an optimal material for cell cultures as it lacks adhesion moieties specific to mammalian cells, and modifications such as hydrogel integration and chemical vapor deposition are necessary to make it a favorable scaffolding material. The present study focuses on modification of filter paper through electrospin-coating and dip-coating with polycaprolactone (PCL), a promising biomaterial in tissue engineering. Morphological analysis, evaluation of cell viability, alkaline phosphatase (ALP) activity and live/dead assays were conducted to study the potential of the modified paper-based scaffold. The results were compared to filter paper (FP) and electrospun PCL (ES-PCL) as reference samples. The results indicate that electrospin-coating paper is a simple and efficient way of modifying FP. It not only improves the morphology of the deposited electrospun layer through reduction of the fiber diameter by nearly 75%, but also greatly reduces the scaffold fabrication time compared to ES-PCL. The biochemical assays (Resazurin and ALP) indicate that electrospin-coated filter paper (ES-PCL/FP) provides significantly higher readings compared to all other groups. The live/dead results also show improved cell-distribution and cell-scaffold attachment all over the ES-PCL/FP.

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Development of a novel Cissus quadrangularis extract loaded sodium alginate/chitosan based 3D printed scaffold for regeneration of cancellous alveolar bone

Padhihary,

Pramanik

2025

Journal of Drug Delivery Science and Technology

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Electrospun Biopolyesters: Hydrophobic Scaffolds with Favorable Biological Response

Cited by 4 publications

References 28 publications

High-throughput production of silk fibroin-based electrospun fibers as biomaterial for skin tissue engineering applications

High-throughput production of silk fibroin-based electrospun fibers as biomaterial for skin tissue engineering applications

Electrospin-Coating of Paper: A Natural Extracellular Matrix Inspired Design of Scaffold

Development of a novel Cissus quadrangularis extract loaded sodium alginate/chitosan based 3D printed scaffold for regeneration of cancellous alveolar bone

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