Electrospun biphasic tubular scaffold with enhanced mechanical properties for vascular tissue engineering

Abdal‐hay, Abdalla; Bartnikowski, Michal; Hamlet, Stephen; Ivanovski, Sašo

doi:10.1016/j.msec.2017.08.041

Cited by 65 publications

(40 citation statements)

References 38 publications

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“…%) are shown in Figure 6a. PCL produced two peaks at approximately 23.8 and 21.38° as reported previously [37]. The two composites produced an extra peak, at 37° (Fig.…”

Section: X-ray Diffraction (Xrd) Analysissupporting

confidence: 82%

Fabrication of a thick three-dimensional scaffold with an open cellular-like structure using airbrushing and thermal cross-linking of molded short nanofibers

2018

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Nanoscale fibers mimicking the extracellular matrix of natural tissue can be produced by conventional electrospinning, but this approach results in two-dimensional thin dense fibrous mats which can hinder effective cell infiltration. The aim of the present study was to design a thick, three-dimensional (3D) cylindrical scaffold with an open pore structure assembled from short polycaprolactone (PCL) fibers using a facile airbrushing approach. In addition, magnesium-particles were incorporated into the PCL solution to both enhance the mechanical properties of the scaffold and stimulate cellular activity following cell seeding. Separated short composite airbrushed fibers were assembled into a 3D cylindrical structure by cold-press molding and thermal crosslinking. The microstructure, chemical composition, porosity and thermal properties were subsequently investigated, along with changes in mechanical performance following immersion in PBS for 60 days. The results showed that the assembled 3D fibrous 10 mm thick cylindrical matrix had an interconnected fibrous network structure with 31.5-60 % porosity. Encapsulation of the Mg particles into the 3D assembled fibrous scaffold enhanced the mechanical properties of the plain PCL scaffolds. The results also demonstrated controlled release of Mg ions into the PBS media for up to 60 days, as evaluated by changes in Mg ion concentration and pH of the media. In addition, the 3D fibrous assembled matrix was shown to support human osteoblast-like cell adhesion, proliferation and penetration. The results suggest that this novel fabrication method of biodegradable thick 3D scaffolds with an open pore structure is promising for the production of a new generation of 3D scaffolds for tissue regeneration applications.

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“…%) are shown in Figure 6a. PCL produced two peaks at approximately 23.8 and 21.38° as reported previously [37]. The two composites produced an extra peak, at 37° (Fig.…”

Section: X-ray Diffraction (Xrd) Analysissupporting

confidence: 82%

Fabrication of a thick three-dimensional scaffold with an open cellular-like structure using airbrushing and thermal cross-linking of molded short nanofibers

2018

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“…The device stiffness and strength are important characteristics that dene the interface with existing tissue and the pressure tolerance of the vascular scaffolds. 41,42 Fig. 11(a) shows that the longitudinal strength and modulus of foamed PCL70 was bigger than that of PCL50.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Fabrication of fibrillated and interconnected porous poly(ε-caprolactone) vascular tissue engineering scaffolds by microcellular foaming and polymer leaching

et al. 2020

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“…The changes in the carbonyl stretches are indicative of strong hydrogen bonding between the amide groups of Vectran and urethane moieties of Hydrothane; it suggests that the hydrogen bonding is significant enough to impart new properties in the HVC fibers, rather than the properties being similar to the sum of their neat counterparts. Note that other electrospun fibers have shown that hydrogen bonding has led to increases in mechanical modulus and strength . Notably, the contributions of aromatic CC and CH stretches (1600/1505 and 3075 cm −1 , respectively) were absent in the HVC spectra.…”

Section: Resultsmentioning

confidence: 88%

Electrospinning of Tough and Elastic Liquid Crystalline Polymer–Polyurethane Composite Fibers: Mechanical Properties and Fiber Alignment

Bertocchi

Simbana

Wynne

et al. 2019

Macro Materials & Eng

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Tough and elastic microfiber composites composed of an elastic polyurethane (Hydrothane) and a liquid crystalline polymer (Vectran) are fabricated via electrospinning. The composite fibers (HVC) are examined as a function of the mixing ratio of the polymers and evaluated on the bases of fiber formation, morphology, thermal properties, mechanical performance, and fiber alignment. The fiber diameters of the HVCs decrease as the content of Vectran increases. When the fibers are aligned via a rotating target, they have even smaller diameters and increased uniformity than when a static target is employed. Surprisingly, the aligned fibers’ mechanical properties are different than those of random orientation; the HVC fibers of random orientation display increases in strength, toughness, and elastic modulii when increasing amounts of Vectran are incorporated in the fibers. The aforementioned mechanical properties of the aligned fibers decrease somewhat as the content of Vectran is increased. Further, the durability of the aligned fibers is examined by extensional durability tests over ten cycles. The tests indicate that the HVC fibers are very durable and can function as tunable, tough, and elastic fibrous polymer scaffolds and have potential applications in high‐performance composites, polymeric filtration devices, and fibrous bioengineering materials.

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Electrospun biphasic tubular scaffold with enhanced mechanical properties for vascular tissue engineering

Cited by 65 publications

References 38 publications

Fabrication of a thick three-dimensional scaffold with an open cellular-like structure using airbrushing and thermal cross-linking of molded short nanofibers

Fabrication of a thick three-dimensional scaffold with an open cellular-like structure using airbrushing and thermal cross-linking of molded short nanofibers

Fabrication of fibrillated and interconnected porous poly(ε-caprolactone) vascular tissue engineering scaffolds by microcellular foaming and polymer leaching

Electrospinning of Tough and Elastic Liquid Crystalline Polymer–Polyurethane Composite Fibers: Mechanical Properties and Fiber Alignment

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