Electrospun cellulose Nano fibril reinforced PLA/PBS composite scaffold for vascular tissue engineering

Abudula, Tuerdimaimaiti; Saeed, Usman; Memić, Adnan; Gauthaman, Kalamegam; Hussain, Mohammad Asif; Al-Turaif, Hamad

doi:10.1007/s10965-019-1772-y

Cited by 71 publications

(47 citation statements)

References 44 publications

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Section: Methodsmentioning

confidence: 99%

“…Dulbecco's Modified Eagle's Medium (DMEM, 1X) was obtained from Lonza, USA. PGS (M w = 12,000) was synthesized according to a previously reported procedure [16]. Briefly, polycondensation of mixed glycerol and sebacic acid with 1:1 molar ratio was performed at 120 • C, under approximately 5 Pa of high vacuum condition.…”

Section: Methodsmentioning

confidence: 99%

“…In general, electrospinning is a versatile, cost-effective, scalable and robust technique to produce nanofibrous scaffolds, which resemble the native extracellular matrix (ECM) of human tissues [15]. This technique provides a tremendous opportunity in scaffold design, in which a large variety of materials, such as polymers, ceramics and inorganic materials, can be easily combined to form a nanofiber composites with unique and multifunctional features [15][16][17][18]. Furthermore, loading and releasing bioactive agents can be controlled by multiple strategies, such as initial blending, controlling polymer hydrophobicity, nozzle configuration and physical/chemical conjugation [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Oxygen-Releasing Antibacterial Nanofibrous Scaffolds for Tissue Engineering Applications

et al. 2020

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Lack of suitable auto/allografts has been delaying surgical interventions for the treatment of numerous disorders and has also caused a serious threat to public health. Tissue engineering could be one of the best alternatives to solve this issue. However, deficiency of oxygen supply in the wounded and implanted engineered tissues, caused by circulatory problems and insufficient angiogenesis, has been a rate-limiting step in translation of tissue-engineered grafts. To address this issue, we designed oxygen-releasing electrospun composite scaffolds, based on a previously developed hybrid polymeric matrix composed of poly(glycerol sebacate) (PGS) and poly(ε-caprolactone) (PCL). By performing ball-milling, we were able to embed a large percent of calcium peroxide (CP) nanoparticles into the PGS/PCL nanofibers able to generate oxygen. The composite scaffold exhibited a smooth fiber structure, while providing sustainable oxygen release for several days to a week, and significantly improved cell metabolic activity due to alleviation of hypoxic environment around primary bone-marrow-derived mesenchymal stem cells (BM-MSCs). Moreover, the composite scaffolds also showed good antibacterial performance. In conjunction to other improved features, such as degradation behavior, the developed scaffolds are promising biomaterials for various tissue-engineering and wound-healing applications.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Oxygen-Releasing Antibacterial Nanofibrous Scaffolds for Tissue Engineering Applications

et al. 2020

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“…The high shearing force yields CNF having shear-thinning behavior with a high aspect ratio [ 79 , 80 ]. The electrospinning of CNF, PLA, and polybutylene succinate (PBS) can generate a composite with cell attachment and proliferation process that could be suitable for tissue regeneration applications with better mechanical properties and biodegradability due to the reinforcement by CNF [ 81 ]. The unique properties of CNF have been employed throughout various applications, such as food, drug delivery, electronic, tissue engineering, and cosmetic applications.…”

Section: Cellulose-based Polymers In 3d Printing Technologymentioning

confidence: 99%

Extending Cellulose-Based Polymers Application in Additive Manufacturing Technology: A Review of Recent Approaches

et al. 2020

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The materials for additive manufacturing (AM) technology have grown substantially over the last few years to fulfill industrial needs. Despite that, the use of bio-based composites for improved mechanical properties and biodegradation is still not fully explored. This limits the universal expansion of AM-fabricated products due to the incompatibility of the products made from petroleum-derived resources. The development of naturally-derived polymers for AM materials is promising with the increasing number of studies in recent years owing to their biodegradation and biocompatibility. Cellulose is the most abundant biopolymer that possesses many favorable properties to be incorporated into AM materials, which have been continuously focused on in recent years. This critical review discusses the development of AM technologies and materials, cellulose-based polymers, cellulose-based three-dimensional (3D) printing filaments, liquid deposition modeling of cellulose, and four-dimensional (4D) printing of cellulose-based materials. Cellulose-based AM material applications and the limitations with future developments are also reviewed.

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“…At the same time, synthetic polymers also have the shortcoming of lacking cell binding sites. Natural materials such as gelatin [36], collagen [37], cellulose [38], chitosan [39], silk fibroin [40], mainly from plants, and animals have excellent biocompatibility, and there are biological sites on the surface that can be specifically recognized by cell integrins which can promote cell adhesion migration and proliferation and accelerate tissue regeneration and reconstruction [41]. Biological dressings not only have better water permeability and air permeability but also can resist the invasion of bacteria and prevent infection.…”

Section: Introductionmentioning

confidence: 99%

Advances in Electrospinning of Natural Biomaterials for Wound Dressing

Fa-dong

Jia

et al. 2020

Journal of Nanomaterials

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Electrospinning has been recognized as an efficient technique for the fabrication of polymer nanofibers. Various polymers have been successfully electrospun into ultrafine fibers in recent years. These electrospun biopolymer nanofibers have potential applications for wound dressing based upon their unique properties. In this paper, a comprehensive review is presented on the researches and developments related to electrospun biopolymer nanofibers including processing, structure and property, characterization, and applications. Information of those polymers together with their processing condition for electrospinning of ultrafine fibers has been summarized in the paper. The application of electrospun natural biopolymer fibers in wound dressings was specifically discussed. Other issues regarding the technology limitations, research challenges, and future trends are also discussed.

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Electrospun cellulose Nano fibril reinforced PLA/PBS composite scaffold for vascular tissue engineering

Cited by 71 publications

References 44 publications

Oxygen-Releasing Antibacterial Nanofibrous Scaffolds for Tissue Engineering Applications

Oxygen-Releasing Antibacterial Nanofibrous Scaffolds for Tissue Engineering Applications

Extending Cellulose-Based Polymers Application in Additive Manufacturing Technology: A Review of Recent Approaches

Advances in Electrospinning of Natural Biomaterials for Wound Dressing

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