Electrospun chitosan/polyethylene-oxide (PEO)/halloysites (HAL) membranes for bone regeneration applications

Govindasamy, Kavitha; Dahlan, Nuraina Anisa; Pushpamalar, Janarthanan; Goh, Kheng Lim; Chai, Siang‐Piao; Pasbakhsh, Pooria

doi:10.1016/j.clay.2020.105601

Cited by 73 publications

(35 citation statements)

References 62 publications

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“…In recent years, hybrid nanomaterials composed by biopolymers and inorganic nanoparticles have attracted growing interest within several fields, including biomedicine [ 1 , 2 , 3 , 4 , 5 ], pharmaceutics [ 6 , 7 , 8 , 9 , 10 ], food packaging [ 11 , 12 , 13 , 14 , 15 ], remediation [ 16 , 17 ] and cultural heritage [ 18 , 19 , 20 ]. As evidenced in a recent review [ 21 ], both ionic and non-ionic polysaccharides can be suitable polymers for the development of functional nanocomposites, with excellent performances in terms of thermal stability, barrier properties and mechanical behavior.…”

Section: Introductionmentioning

confidence: 99%

Halloysite Nanotubes Coated by Chitosan for the Controlled Release of Khellin

2020

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In this work, we have developed a novel strategy to prepare hybrid nanostructures with controlled release properties towards khellin by exploiting the electrostatic interactions between chitosan and halloysite nanotubes (HNT). Firstly, khellin was loaded into the HNT lumen by the vacuum-assisted procedure. The drug confinement within the halloysite cavity has been proved by water contact angle experiments on the HNT/khellin tablets. Therefore, the loaded nanotubes were coated with chitosan as a consequence of the attractions between the cationic biopolymer and the halloysite outer surface, which is negatively charged in a wide pH range. The effect of the ionic strength of the aqueous medium on the coating efficiency of the clay nanotubes was investigated. The surface charge properties of HNT/khellin and chitosan/HNT/khellin nanomaterials were determined by ζ potential experiments, while their morphology was explored through Scanning Electron Microscopy (SEM). Water contact angle experiments were conducted to explore the influence of the chitosan coating on the hydrophilic/hydrophobic character of halloysite external surface. Thermogravimetry (TG) experiments were conducted to study the thermal behavior of the composite nanomaterials. The amounts of loaded khellin and coated chitosan in the hybrid nanostructures were estimated by a quantitative analysis of the TG curves. The release kinetics of khellin were studied in aqueous solvents at different pH conditions (acidic, neutral and basic) and the obtained data were analyzed by the Korsmeyer–Peppas model. The release properties were interpreted on the basis of the TG and ζ potential results. In conclusion, this study demonstrates that halloysite nanotubes wrapped by chitosan layers can be effective as drug delivery systems.

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Section: Introductionmentioning

confidence: 99%

Halloysite Nanotubes Coated by Chitosan for the Controlled Release of Khellin

2020

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“…Experiments demonstrated that this chitosan/HAp/collagen biocomposite scaffold significantly improved bone formation compared to HAp alone [ 133 ]. In another recent study, a scaffold of electrospun ChNFs reinforced with halloysite nanotubes (aluminosilicate clay mineral, HAL) was designed and fabricated for bone regeneration [ 134 , 135 , 136 , 137 ]. These nanofibers incorporated approximately 5 wt% HAL and had a diameter of approximately 120 nm.…”

Section: Chitosan-based Nanofibers In Biomedical Applicationsmentioning

confidence: 99%

Recent Developments in Chitosan-Based Micro/Nanofibers for Sustainable Food Packaging, Smart Textiles, Cosmeceuticals, and Biomedical Applications

et al. 2021

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Chitosan has many useful intrinsic properties (e.g., non-toxicity, antibacterial properties, and biodegradability) and can be processed into high-surface-area nanofiber constructs for a broad range of sustainable research and commercial applications. These nanofibers can be further functionalized with bioactive agents. In the food industry, for example, edible films can be formed from chitosan-based composite fibers filled with nanoparticles, exhibiting excellent antioxidant and antimicrobial properties for a variety of products. Processing ‘pure’ chitosan into nanofibers can be challenging due to its cationic nature and high crystallinity; therefore, chitosan is often modified or blended with other materials to improve its processability and tailor its performance to specific needs. Chitosan can be blended with a variety of natural and synthetic polymers and processed into fibers while maintaining many of its intrinsic properties that are important for textile, cosmeceutical, and biomedical applications. The abundance of amine groups in the chemical structure of chitosan allows for facile modification (e.g., into soluble derivatives) and the binding of negatively charged domains. In particular, high-surface-area chitosan nanofibers are effective in binding negatively charged biomolecules. Recent developments of chitosan-based nanofibers with biological activities for various applications in biomedical, food packaging, and textiles are discussed herein.

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“…A moderate water-resistance of nanofiber property is required in their use for adsorption and filtration applications despite the typical CS biodegradability in water. This measurement is a widely used method for evaluating the hydrophilicity/hydrophobicity where relatively small contact angles correspond to moderately hydrophilic surfaces [54]. The precise crosslinking reaction mechanism between CS and PEO blend is not well defined and it is not known whether the polymeric chains are linked via a chemical reaction between the two different polymers or between the crosslinking agent and the polymer.…”

Section: Surface Wettability Test Of Crosslinked Ttm-cpnf-2mentioning

confidence: 99%

Chitosan/PEO nanofibers electrospun on metallized track-etched membranes: fabrication and characterization

Pereao

Uche

Bublikov

et al. 2021

Materials Today Chemistry

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The development of next-generation adsorption, separation, and filtration materials is growing with an increased research focus on polymer composites. In this study, a novel blend of chitosan (CS) and polyethylene oxide (PEO) nanofiber mats was electrospun on titanium (Ti)-coated polyethylene terephthalate (PET) track-etched membranes (TMs) with after-treatment by glutaraldehyde in the vapor phase for enhancing the nanofiber stability by crosslinking. The prepared composite, titanium-coated track-etched nanofiber membrane (TTM-CPnf) was characterized by Fourier transform infra-red (FTIR), water contact angle, and scanning electron microscopy (SEM) analyses. Smooth and uniform CS nanofibers with an average fiber diameter of 156.55 nm were produced from a 70/30 CS/PEO blend solution prepared from 92 wt. % acetic acid and electrospun at 15 cm needle to collector distance with 0.5 mL/h flow rate and an applied voltage of 30 kV on the TTM-CPnf. Short (15 min) and long (72 h)-term solubility tests showed that after 3 h, crosslinked nanofibers were stable in acidic (pH ¼ 3), basic (pH ¼ 13), and neutral (pH ¼ 7) solutions. The crosslinked TTM-CPnf material was biocompatible based on the low mortality of freshwater crustaceans Daphnia magna. The composite membranes comprised of electrospun nanofiber and TMs proved to be biocompatible and may thus be suitable for diverse applications such as dual adsorptionefiltration systems in water treatment.

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Electrospun chitosan/polyethylene-oxide (PEO)/halloysites (HAL) membranes for bone regeneration applications

Cited by 73 publications

References 62 publications

Halloysite Nanotubes Coated by Chitosan for the Controlled Release of Khellin

Halloysite Nanotubes Coated by Chitosan for the Controlled Release of Khellin

Recent Developments in Chitosan-Based Micro/Nanofibers for Sustainable Food Packaging, Smart Textiles, Cosmeceuticals, and Biomedical Applications

Chitosan/PEO nanofibers electrospun on metallized track-etched membranes: fabrication and characterization

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