Electrospun Doxorubicin-loaded PEO/PCL core/sheath nanofibers for chemopreventive action against breast cancer cells

Darbasizadeh, Behzad; Mortazavi, Seyed Alireza; Kobarfard, Farzad; Jaafari, Mahmoud Reza; Hashemi, Atieh; Farhadnejad, Hassan; Feyzi-barnaji, Bahareh

doi:10.1016/j.jddst.2021.102576

Cited by 36 publications

(29 citation statements)

References 55 publications

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“…As shown in Figure 6, the melting temperature of PCL nanofibers is in the range of 54−56 °C, which is reported by some research studies 57,58 and is suitable for homogeneous PCL nanofibers. With the addition of the PEG polymer, the melting temperature was changed to 65 °C because the polymers reacted chemically with each other and ester bonds were formed between the two functional groups of PCL and PEG, and crystalline regions may also be formed in PCL and PEG; 57,59 also, this increase in melting temperature indicates the reaction of hydrogen bonds between polymer chains. 44 As ibuprofen was added to this copolymer, the melting temperature was reduced to 60 °C.…”

Section: In Vitro Ibuprofenmentioning

confidence: 56%

Ibuprofen-Loaded Electrospun PCL/PEG Nanofibrous Membranes for Preventing Postoperative Abdominal Adhesion

Kheilnezhad

Hadjizadeh

2022

ACS Appl. Bio Mater.

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Electrospun nanofibrous membranes are a widely used physical barrier for reducing postoperative adhesion. However, these physical barriers could not prevent adhesion formation completely. Because a high-intensity inflammation occurs in the surgical area, the presence of relevant drugs to control such an inflammation is desperately needed. In this study, we fabricated an electrospun composite ibuprofen-loaded poly(ethylene glycol) (PEG)/polycaprolactone (PCL) nanofibrous membrane (NFM) to prevent abdominal adhesions. This membrane aimed to act as a barrier between the abdominal wall and surrounding tissues, without interrupting mass transfer and normal wound healing. Among various fabricated composite NFMs, PCL/25PEG-6% NFMs showed the lowest fiber diameter (448.8 ± 124.4 nm), the smallest pore size (<2 μm), and moderate ultimate stress and strain. The PCL/25PEG-6% NFMs had the lowest water contact angle (≈75°) and the highest drug profile release (≈80%) within 14 days. Furthermore, in vitro toxicity examination of PCL/25PEG-6% toward fibroblast cells demonstrated a cell viability of ≈82% after 3 days, proving its prolonged antiadhesion ability. In addition, the low number of adherent cells with a rounded shape and low cell proliferation on these NFMs indicated their special antiadhesive effects. Collectively, these results indicated that the PCL/25PEG-6% membrane might be a suitable barrier to prevent abdominal adhesion.

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Section: In Vitro Ibuprofenmentioning

confidence: 56%

Ibuprofen-Loaded Electrospun PCL/PEG Nanofibrous Membranes for Preventing Postoperative Abdominal Adhesion

Kheilnezhad

Hadjizadeh

2022

ACS Appl. Bio Mater.

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“…In the literature, it has been reported that PEO containing nanofibers such as PEO/PCL electrospun nanofibers [32] and sodium alginate/poly(ethylene oxide) electrospun nanofibers [33] are non‐toxic. According to the MTT assay, PEO and PTh/PSDA/PEO4 electrospun nanofibers are also non‐toxic.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of Water‐Soluble Polythiophene/Poly (sulfonic acid diphenyl aniline)/Polyethylene Oxide Electrospun Nanofibers and Their Antioxidant Activities

Hüner

2022

ChemistrySelect

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The fabrication and antioxidant properties of polythiophene/ poly(sulfonic acid diphenyl aniline)/polyethylene oxide electrospun nanofibers obtained in this study were brought to the literature for the first time. For this, polythiophene/poly(sulfonic acid diphenyl aniline)/polyethylene oxide (PTh/PSDA/PEO) nanofibers containing 5, 10, 20 and 40 % PTH/PSDA composite by weight were produced by electrospinning method. According to both CUPRAC and ABTS assays, these electrospun nanofibers were found to have antioxidant activity. According to both CUPRAC and ABTS assays, the highest antioxidant activity was obtained from PTh/PSDA/PEO4 electrospun nanofiber containing 40 % PTH/PSDA with values of 244 and 111 μg TE/mg, respectively. This nanofiber was found to be non-toxic according to the MTT assay and its thermal stability was not much different from that of the PEO nanofiber. PTh/PSDA/PEO electrospun nanofibers were biocompatible, water-soluble nanofibers that were candidates for use in many biological applications with further characterization. These electrospun nanofibers were characterized by FT-IR, UV-Vis., 1 H NMR, XRD and TGA. Surface morphologies were investigated by SEM.

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“…A small addition of 0.5% MC and PEG molecules into the nanofiber mats showed greater changes in the decomposition phenomena. 28,39,40 Overall, the hydrophilic nature of MgO, MC, and PEG and their interactions alter the thermal stability of nanofiber mats compared to pristine NF. This phenomenon was further supported by the decreased tensile strength and elongation at break.…”

Section: Energy Dispersive X-ray Analysismentioning

confidence: 99%

“…However, the crystalline nature was significantly decreased due to the supply of hydrophilicity by MgO, MC, and PEG and, hence, the endothermic peaks of PCL and 5Fu were reduced to 44 and 275 °C. 27,28,40 3.6. Hydrophilicity of Nanofiber Mats.…”

Section: Differential Scanning Calorimetric Analysismentioning

confidence: 99%

A Study on the Effect of Nanoscale MgO and Hydrogen Bonding in Nanofiber Mats for the Controlled Drug Release along with In Vitro Breast Cancer Cell Line and Antimicrobial Studies

Jaisankar¹,

Azarudeen²,

Thirumarimurugan³

2022

ACS Appl. Bio Mater.

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Nanosized metal oxide-incorporated drug carriers have received significant attention due to their biocompatibility, mechanical strength, controlled drug release, and biodegradability. Herein, an attempt was made to fabricate polycaprolactone-based electrospun nanofiber mats involving the 5-fluorouracil (5Fu) drug, MgO nanoparticle, methyl cellulose, and polyethylene glycol. The chemical interactions, surface wettability, mechanical properties, structural and morphological changes, and thermal stability were studied by the respective analyses. The ionic interaction between 5Fu, MgO, and polymers were found to be responsible for the controlled drug release. Zero-order kinetic and model data also revealed that a controlled drug release pattern was observed in a period of 16 days. Furthermore, the nanofiber mats were subjected to cytotoxicity studies against MDA-MB-231 cancer cell line and the results showed higher cytotoxicity in a short time of 24 h and less toxicity to normal L929 fibroblast cell line. The apoptosis in cancer cell lines was also tested by AO/PI staining assay and confirmed by fluorescence microscopy. In addition, the growth inhibition of several bacterial and fungal strains was tested for the mats and the results exhibited good inhibition activity. Hence, the reported nanofiber drug carrier was found to be an efficient implant for the controlled release of anticancer drug along with other significant properties.

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Electrospun Doxorubicin-loaded PEO/PCL core/sheath nanofibers for chemopreventive action against breast cancer cells

Cited by 36 publications

References 55 publications

Ibuprofen-Loaded Electrospun PCL/PEG Nanofibrous Membranes for Preventing Postoperative Abdominal Adhesion

Ibuprofen-Loaded Electrospun PCL/PEG Nanofibrous Membranes for Preventing Postoperative Abdominal Adhesion

Fabrication of Water‐Soluble Polythiophene/Poly (sulfonic acid diphenyl aniline)/Polyethylene Oxide Electrospun Nanofibers and Their Antioxidant Activities

A Study on the Effect of Nanoscale MgO and Hydrogen Bonding in Nanofiber Mats for the Controlled Drug Release along with In Vitro Breast Cancer Cell Line and Antimicrobial Studies

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