Electrospun drug loaded membranes for sublingual administration of sumatriptan and naproxen

Vrbata, Petr; Berka, Pavel; Stránská, Denisa; Doležal, Pavel; Musilová, Marie; Čižinská, Lucie

doi:10.1016/j.ijpharm.2013.08.085

Cited by 69 publications

(45 citation statements)

References 34 publications

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“…The changes in the drug's crystallinity due to the electrospinning of the PCL solution were already reported in previous studies (Kouhi et al, 2013;Seif et al, 2015;Valarezo et al, 2013;Vrbata et al, 2013;Zamani et al, 2010). The group of Vrbata confirmed the changed crystalline structure of naproxen and sumatriptan succinate when incorporated into PCL nanofibers (Vrbata et al, 2013).…”

Section: Evaluation Of the Drug's Crystallinitysupporting

confidence: 76%

“…The theoretical drug loading in the nanofibers reached up to 37.5% (w/w) (Table 2) in the case of nanofibers with 60% of drug based on the dry weight of the polymer. The achieved drug loading was higher than all the available previously published data, where the drug loading did not exceed about 30% (w/w) (based on the dry weight of the polymer) (Vrbata et al, 2013). A high drug loading can significantly affect the electrospun product's morphology, as shown in Fig.…”

Section: Morphology Of the Electrospun Products And Polymer Filmsmentioning

confidence: 62%

“…In the DSC curves of all the drug-loaded nanofibers the endothermic peak, which would indicate melting of the drug, is absent. This finding suggests that the ibuprofen and carvedilol were molecularly dispersed in the polymer matrix, indicating the formation of a solid solution (Bodmeier and Chen, 1989;Kouhi et al, 2013;Seif et al, 2015;Vrbata et al, 2013;Zamani et al, 2010) or the drugs were amorphous (Kouhi et al, 2013;Vrbata et al, 2013). However, the glass transition temperatures were not observed for any sample of drug-loaded nanofibers or films in the scope of our study.…”

Section: Evaluation Of the Drug's Crystallinitymentioning

confidence: 64%

“…PCL has previously been reported as a main building block of different PCLbased formulations, e.g., micro and nanospheres (Sinha et al, 2004), films, micelles, scaffolds, and fibers (Dash and Konkimalla, 2012;Woodruff and Hutmacher, 2010). It has also been successfully electrospun in previous studies (Canbolat et al, 2014;Fujihara et al, 2005;Karuppuswamy et al, 2015;Kenawy et al, 2009;Kim et al, 2012;Kouhi et al, 2013;Li et al, 2005;LuongVan et al, 2006;Madhaiyan et al, 2013;Reneker et al, 2002;Seif et al, 2015;Shin et al, 2004;Srikar et al, 2007;Valarezo et al, 2013;Vrbata et al, 2013;Yoshimoto et al, 2003;Zamani et al, 2010).…”

Section: Preparation Of Drug-loaded Pcl Nanofiber Matsmentioning

confidence: 99%

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Electrospun polycaprolactone nanofibers as a potential oromucosal delivery system for poorly water-soluble drugs

Potrč

Baumgartner

Roškar

et al. 2015

European Journal of Pharmaceutical Sciences

150

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Section: Evaluation Of the Drug's Crystallinitysupporting

confidence: 76%

Section: Morphology Of the Electrospun Products And Polymer Filmsmentioning

confidence: 62%

Section: Evaluation Of the Drug's Crystallinitymentioning

confidence: 64%

Section: Preparation Of Drug-loaded Pcl Nanofiber Matsmentioning

confidence: 99%

See 2 more Smart Citations

Electrospun polycaprolactone nanofibers as a potential oromucosal delivery system for poorly water-soluble drugs

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Roškar

et al. 2015

European Journal of Pharmaceutical Sciences

150

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“…5) Electrospinning, a technique of producing thin strands of fiber using high voltage, has opened up opportunities in the development of drug delivery systems. An optimized electrospinning process can produce nano-sized fibers.…”

mentioning

confidence: 99%

Intermolecular Interactions and the Release Pattern of Electrospun Curcumin-Polyvinyl(pyrrolidone) Fiber

Rahma

Munir

Khairurrijal

et al. 2016

Biological & Pharmaceutical Bulletin

167

104

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An electrospun fiber of polyvinyl(pyrrolidone) (PVP)-Tween 20 (T20) with curcumin as the encapsulated drug has been developed. A study of intermolecular interactions was performed using Raman spectroscopy, Fourier transform infrared (FT-IR), differential scanning calorimetry (DSC), and X-ray diffraction (XRD).The Raman and FT-IR studies showed that curcumin preferrably interacted with T20 and altered PVP chain packing, as supported by XRD and physical stability data. The hydroxyl stretching band in PVP shifted to a lower wavenumber with higher intenstity in the presence of curcumin and PVP, indicating that hydrogen bond formation is more intense in a curcumin or curcumin-T20 containing fiber. The thermal pattern of the fiber did not indicate phase separation. The conversion of curcumin into an amorphous state was confirmed by XRD analysis. An in vitro release study in phosphate buffer pH 6.8 showed that intermolecular interactions between each material influenced the drug release rate. However, low porosity was found to limit the hydrogen bond-mediated release.Key words curcumin; fiber; electrospinning; interaction; porosity; polymeric drug delivery system Curcumin is the major constituent of turmeric rhizome (Curcuma sp.).1) Curcumin has a number of demonstrated pharmacological effects, such as antioxidant, anti-inflammatory, anticancer, hepatoprotective, 1) antimicrobial, and antiviral. 2)Clinical trials have proven that curcumin is well tolerated by the body, with a maximum dose of 12 g daily.3) Unfortunately, the efficacy of curcumin is limited by its poor solubility in water, as well as its instability under light, heat, and alkaline conditions.1) The solubility of curcumin in aqueous buffer (pH 5) is reported to be 11 ng/mL.3) Moreover, the absorption of curcumin in the gastrointestinal tract is very low, leading to poor bioavailability (in animals and humans).2) Therefore, designing an effective delivery system is necessary in order to address the limitations of curcumin use. 1-3)A wide range of drug delivery systems has been developed to improve the bioavailability of poorly soluble drugs, including fast-dissolving tablets, 4) incorporation into a hydrophilic complex, 1) micellization, and solid dispersion. 5) Electrospinning, a technique of producing thin strands of fiber using high voltage, has opened up opportunities in the development of drug delivery systems. An optimized electrospinning process can produce nano-sized fibers. 6)The high surface area and porosity of these electrospun fibers are advantageous in their use as carriers for poorly water-soluble drugs.5) The high surface area generally increases the dissolution rate of the incorporated drug, thus potentially enhancing its bioavailability. 5)Therefore, the incorporation of curcumin into an electrospun fiber is expected to improve its oral bioavailability.Tailoring a suitable drug-loaded fiber requires careful selection of materials, in addition to an optimized production process and environment. Generally, the drug is mixed with a polymer s...

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Plasticized Drug‐Loaded Melt Electrospun Polymer Mats: Characterization, Thermal Degradation, and Release Kinetics

Balogh

Drávavölgyi

Faragó

et al. 2014

Journal of Pharmaceutical Sciences

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Electrospun drug loaded membranes for sublingual administration of sumatriptan and naproxen

Cited by 69 publications

References 34 publications

Electrospun polycaprolactone nanofibers as a potential oromucosal delivery system for poorly water-soluble drugs

Electrospun polycaprolactone nanofibers as a potential oromucosal delivery system for poorly water-soluble drugs

Intermolecular Interactions and the Release Pattern of Electrospun Curcumin-Polyvinyl(pyrrolidone) Fiber

Plasticized Drug‐Loaded Melt Electrospun Polymer Mats: Characterization, Thermal Degradation, and Release Kinetics

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