Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization

Sun, Yue; Cheng, Shihong; Lu, Wenjuan; Wang, Yanfeng; Zhang, Pingping; Yao, Qingqiang

doi:10.1039/c9ra05012d

Cited by 181 publications

(135 citation statements)

References 146 publications

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“…diffusion and the swelling of PVA fibers, which happened immediately upon contact with the buffer solution. In contrast to this, the n values in phase II are markedly lower than 0.45, which is consistent with a Fick-type diffusion mechanism [83][84][85][86][87].…”

Section: Growth Inhibition Studies-minimal Inhibitory Concentrationsupporting

confidence: 70%

“…For phase II, R 2 values of 0.97 and 0.99 were obtained and exponents of 0.14 and 0.15 were obtained as well, respectively. Values for phase I lying between 0.45 and 0.89 indicate that the release of TSC from the PVA mats represents anomalous transport diffusion [83][84][85][86][87], which is probably governed by a combination of TSC diffusion and the swelling of PVA fibers, which happened immediately upon contact with the buffer solution. In contrast to this, the n values in phase II are markedly lower than 0.45, which is consistent with a Fick-type diffusion mechanism [83][84][85][86][87].…”

Section: Release Studiesmentioning

confidence: 99%

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Characterization and Release Behavior of a Thiosemicarbazone from Electrospun Polyvinyl Alcohol Core-Shell Nanofibers

et al. 2020

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Mats of polyvinyl alcohol (PVA) core–shell nanofibers were produced using coaxial electrospinning in the presence of a thiosemicarbazone (TSC) N4-(S)-1-phenylethyl)-2-(pyridin-2-yl-ethylidene)hydrazine-1-carbothioamide (HapyTSCmB). Monolithic fibers with 0% or 5% TSC and core–shell fibers with 10% TSC in the spinning solution were studied to compare stability and release rates. SEM showed the formation of uniform, bead-free, cylindrical, and smooth fibers. NMR spectroscopy and thermal analysis (TG/DTA) gave proof for the chemical integrity of the TSC in the fiber mats after the electrospinning process. Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy showed no TSC on the surface of the PVA/TSC-PVA fibers confirming the core–shell character. The TSC release profiles of the fibers as studied using UV-vis absorption spectroscopy showed a slower release from the PVA/TSC-PVA core–shell structure compared with the monolithic PVA/TSC fibers as well as lower cumulative release percentage (17%). Out of several release models, the Korsmeyer–Peppas model gave the best fit to the experimental data. The main release phase can be described with a Fick-type diffusion mechanism. Antibacterial properties were tested against the Gram-positive Staphylococcus aureus bacterium and gave a minimal inhibitory concentration of 12.5 μg/mL. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazoliumbromide (MTT)-based cytotoxicity experiments showed that the cell viability of fibroblast at different contents of TSC was slightly decreased from 1.5% up to 3.5% when compared to control cells.

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Section: Growth Inhibition Studies-minimal Inhibitory Concentrationsupporting

confidence: 70%

Section: Release Studiesmentioning

confidence: 99%

Characterization and Release Behavior of a Thiosemicarbazone from Electrospun Polyvinyl Alcohol Core-Shell Nanofibers

et al. 2020

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“…Electrospun mats can be used for encapsulation and prolonged release of bioactive substances, including drugs, peptides, and therapeutic proteins. [46][47][48] Incorporation of proteins into electrospun mats can be tricky because most proteins undergo denaturation during electrospinning due to the strong electric eld and the presence of organic solvent. 49 However, some proteins withstand both denaturation factors and retain their functionality aer electrospinning.…”

Section: Bsa Release From the Blended Matsmentioning

confidence: 99%

The miscibility and spatial distribution of the components in electrospun polymer–protein mats

et al. 2020

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“…It is worth mentioning that the surface morphology and properties of electrospun fibers can be affected by (I) the working parameters of the electrospinning process represented by ambient parameters (relative humidity and temperature), solution parameters (polymer concentration, molecular weight, viscosity, conductivity, and surface tension), and processing parameters (flow rate, applied voltage, distance between the tip of the needle and the collector [DTC], collector type, and diameter of the needle); (II) electrospinning types; (III) composites; and (IV) postprocessing treatments …”

Section: Brief Introduction Of Electrospinningmentioning

confidence: 99%

A mini review on the generation of crimped ultrathin fibers via electrospinning: Materials, strategies, and applications

Zaarour

Zhu

Huang

et al. 2020

Polymers for Advanced Techs

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Structures modification of fibers has been attracting significant attention in various fields and applications. Among different techniques of fabricating ultrathin fibers, electrospinning is the most commonly adopted method because of the ease of forming fibers with a wide range of properties and its exceptional advantages, such as the ability to spin into different shapes and sizes, as well as the adaptable porosity of electrospun fiber webs. The crimped structure has been attracting the attention of scientific researchers owing to its unique properties (eg, spring-like behavior, supreme strain, remarkable specific surface area, good piezoelectric properties, excellent biological properties, and so on). Therefore, this study summarizes a review of the strategies and methods, reported so far, of generating electrospun crimped ultrathin fibers of various polymers. The review focuses on the polymer types, formation methods, characterizations, and applications of the electrospun crimped ultrathin fibers. We believe this work can serve as an important reference for the materials, strategies, and applications of crimped fibers.

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Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization

Abstract: Electrospun fibers have gained considerable attention in drug controlled release, biological dressings, tissue repair and enzyme immobilization fields.

Cited by 181 publications

References 146 publications

Characterization and Release Behavior of a Thiosemicarbazone from Electrospun Polyvinyl Alcohol Core-Shell Nanofibers

Characterization and Release Behavior of a Thiosemicarbazone from Electrospun Polyvinyl Alcohol Core-Shell Nanofibers

The miscibility and spatial distribution of the components in electrospun polymer–protein mats

A mini review on the generation of crimped ultrathin fibers via electrospinning: Materials, strategies, and applications

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