Electrospun fibers for tissue engineering, drug delivery, and wound dressing

Goh, Yi Fan; Shakir, Imran; Hussain, Rafaqat

doi:10.1007/s10853-013-7145-8

Cited by 282 publications

(176 citation statements)

References 271 publications

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“…29 The ability to vary the microstructure on a production-scale instrument may also prove to be useful in a number of drug-delivery applications, including wound healing and tissue engineering. [30][31][32] We observed differences in the release of TFV from fabrics of varied loading and microarchitecture ( Figure 7B and E) but not in the release of the more hydrophobic LNG ( Figure 7A). The slower release of TFV seen with increasing fabric thickness is likely due to slower wetting and increased distance for drug diffusion through the fiber matrix.…”

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confidence: 99%

Delivery of multipurpose prevention drug combinations from electrospun nanofibers using composite microarchitectures

Blakney

Krogstad

Jiang

et al. 2014

IJN

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Background Electrospun drug-eluting fabrics have enormous potential for the delivery of physicochemically diverse drugs in combination by controlling the underlying material chemistry and fabric microarchitecture. However, the rationale for formulating drugs at high drug loading in the same or separate fibers is unknown but has important implications for product development and clinical applications. Methods Using a production-scale free-surface electrospinning instrument, we produced electrospun nanofibers with different microscale geometries for the co-delivery of tenofovir (TFV) and levonorgestrel (LNG) – two lead drug candidates for multipurpose prevention of HIV acquisition and unintended pregnancy. We investigated the in vitro drug release of TFV and LNG combinations from composites that deliver the two drugs from the same fiber (combined fibers) or from separate fibers in a stacked or interwoven architecture. For stacked composites, we also examined the role that fabric thickness has on drug-release kinetics. We also measured the cytotoxicity and antiviral activity of the drugs delivered alone and in combination. Results Herein, we report on the solution and processing parameters for the free-surface electrospinning of medical fabrics with controlled microarchitecture and high drug loading (up to 20 wt%). We observed that in vitro release of the highly water-soluble TFV, but not the water-insoluble LNG, was affected by composite microarchitecture, fabric thickness, and drug content. Finally, we showed that the drug-loaded nanofibers are noncytotoxic and that the antiviral activity of TFV is preserved through the electrospinning process and when combined with LNG. Conclusion Electrospun fabrics with high drug loading create multicomponent systems that benefit from the independent control of the nanofibrous microarchitecture. Our findings are significant because they will inform the design and production of composite electrospun fabrics for the co-delivery of physicochemically diverse drugs that may be useful for multipurpose prevention.

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confidence: 99%

Delivery of multipurpose prevention drug combinations from electrospun nanofibers using composite microarchitectures

Blakney

Krogstad

Jiang

et al. 2014

IJN

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“…The jet is only stable at the tip of the spinneret and after that instability starts. 36,[42][43][44][45] Thus, the electrospinning process offers a simplified technique for fiber formation. Fibers obtained from electrospinning are in the range of 50 nm to a few microns in diameter and generally collected in the form of a non-woven structure.…”

Section: Discussionmentioning

confidence: 99%

Electrospinned bioactive glass/nano hydroxyapatite reinforced polycaprolactone GTR/GBR membranes in periodontics- A review

2020

IJPI

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Periodontitis, a chronic inflammatory infectious disease triggered by an interaction between microbial biofilm and host response leading to gingival bleeding, connective tissue destruction , alveolar bone loss and finally causing tooth loss. Periodontal regeneration or restoration is the ultimate goal of any periodontal treatment. This can be achieved by GTR/GBR [Guided Tissue Regeneration/Guided Bone Regeneration] membranes along with bone replacement grafts. With the evolution of Tissue engineering and different generation of GTR/GBR nanofibrous membranes, periodontal restoration or regeneration can be easily and rapidly achieved . Nanofibrous GTR/GBR Membranes can be fabricated using natural or synthetic polymers by different techniques such as Phase separation, Self assembly and Electrospinning [E-spinning]. Of these, E-spinning is the most widely studied technique and also seems to exhibit the most promising results for Tissue Engineering [TE] applications . This review addresses the Electrospinning method of GTR/GBR membrane fabrication using Bioactive Glass [BG]/Nano Hydroxyapatite[nHAP] reinforced polycaprolactone polymer and its advantages and disadvantages.

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“…Electrospinning, a technique that utilises electrostatic forces to produce fibers has been emerging from 100 years ago [4]. This technique is versatile to spin a wide range of materials such as polymers, composites, and ceramics into extremely thin fibers ranging from micrometers to a few nanometers [5]. These thin fibers mimic the structural dimension of extracellular matrix (ECM) of tissues and organs [4].…”

Section: -2506mentioning

confidence: 99%

Comparison on in Vitro Degradation of Polycaprolactone and Polycaprolactone/Gelatin Nanofibrous Scaffold

2017

MJAS

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Tissue engineering has emerged to provide a new medical therapy in helping tissue regrowth and regeneration by employing scaffold as an artificial supporting structure for cellular growth. Many polymers have been utilized in the fabrication of these artificial scaffolds, but there is still a need to fabricate hydrophilic nanofibrous scaffold with appropriate degradation rate. In this study, polycaprolactone (PCL) and polycaprolactone/gelatin (PCL/Ge) 70:30 nanofibrous scaffolds were fabricated using electrospinning technique and compared on in vitro degradation rate to determine a more suitable scaffold for skin tissue engineering application. In vitro degradation was evaluated by morphological changes, water uptake, and chemical bonding until 12 weeks. Result shows that both PCL and PCL/Ge (70:30) nanofibrous scaffolds were degraded after 8th week. However, the degradation rate of PCL nanofibrous scaffold is slower and does not has obvious morphological changes. PCL/Ge (70:30) nanofibrous scaffold with faster degradation rate have the potential for skin tissue engineering application.Keywords: tissue engineering, nanofibrous scaffold, in vitro degradation, polycaprolactone, polycaprolactone/gelatin Abstrak Kejuruteraan tisu muncul untuk menyediakan terapi perubatan baru dalam membantu pertumbuhan semula tisu dengan menggunakan perancah sebagai struktur sokongan tiruan untuk pertumbuhan selular. Banyak polimer telah digunakan dalam penghasilan perancah ini, namun masih wujud permintaan terhadap penghasilan perancah gentian hidrofilik yang bersaiz nano dengan kadar degradasi yang sesuai. Dalam kajian ini, gentian perancah nano polikaprolakton (PCL) dan polikaprolakton/gelatin (PCL/Ge) 70:30 telah dihasilkan dengan teknik putaran elekron dan kadar degradasi in vitro dibandingkan untuk menentukan perancah yang lebih sesuai bagi aplikasi kejuruteraan tisu kulit. Degradasi in vitro telah dinilai melalui perubahan morfologi, penyerapan air, dan ikatan kimia kedua-dua gentian perancah nano sehingga 12 minggu. Keputusan menunjukkan kedua-dua PCL dan PCL/Ge (70:30) gentian perancah nano telah degradasi selepas minggu ke-8. Walau bagaimanapun, kadar degradasi gentian perancah nano PCL adalah lebih perlahan dan tiada perubahan morfologi yang jelas. Gentian perancah nano PCL/Ge (70:30) dengan kadar degradasi yang lebih cepat mempunyai potensi dalam bidang kejuruteraan tisu kulit.Kata kunci: kejuruteraan tisu, perancah gentian nano, degradasi in vitro, polikaprolakton, polikaprolakton/gelatin Introduction Tissue engineering is an interdisciplinary field that uses life sciences and engineering principles to develop biological substitutes for example fibrous scaffold for improving, maintaining and restoring the function of tissues

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Electrospun fibers for tissue engineering, drug delivery, and wound dressing

Cited by 282 publications

References 271 publications

Delivery of multipurpose prevention drug combinations from electrospun nanofibers using composite microarchitectures

Delivery of multipurpose prevention drug combinations from electrospun nanofibers using composite microarchitectures

Electrospinned bioactive glass/nano hydroxyapatite reinforced polycaprolactone GTR/GBR membranes in periodontics- A review

Comparison on in Vitro Degradation of Polycaprolactone and Polycaprolactone/Gelatin Nanofibrous Scaffold

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