Electrospun fibers of poly (lactic acid) containing bioactive glass and magnesium oxide nanoparticles for bone tissue regeneration

Canales, Daniel; Reyes, Felipe E.; Saavedra, Marcela; Peponi, Laura; Leonés, Adrián; Palza, Humberto; Boccaccını, Aldo R.; Grünewald, Alina; Zapata, Paula Andrea

doi:10.1016/j.ijbiomac.2022.05.047

Cited by 32 publications

(27 citation statements)

References 61 publications

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“…Poly(lactic acid) (PLA) was used from MCI electronics (1.75 mm filaments, Sakata 3D filament) with an average molecular weight of M w = 335,173 g/mol. , V. antiqua clamshells from the Chilean Pacific coast were used to synthesize the nanoparticles.…”

Section: Methodsmentioning

confidence: 99%

“…Poly(lactic acid) (PLA) was used from MCI electronics (1.75 mm filaments, Sakata 3D filament) with an average molecular weight of M w = 335,173 g/mol. 45,46 V. antiqua clamshells from the Chilean Pacific coast were used to synthesize the nanoparticles. In addition, As plasticizer was used D-limonene (Aldrich, reagent grade 97%) and ethanol (Winkler, 95%) was used as a solvent for the antimicrobial test.…”

Section: Methodsmentioning

confidence: 99%

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Venus antiqua Clamshell-Derived Calcium Oxide Nanoparticles for the Preparation of PLA/d-Limonene/CaO Nanocomposites with Antimicrobial Properties

Moreno-Serna,

Oyarzún,

Ulloa-Flores

et al. 2023

ACS Sustainable Chem. Eng.

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Antimicrobial films based on poly(lactic acid) (PLA)/Dlimonene/calcium oxide (CaO)-based nanocomposites were prepared by extrusion and successive thermocompression. D-Limonene was incorporated into PLA at a concentration of 5 or 10 wt %. Venus antiqua clamshell-derived calcium oxide (CaO) nanoparticles with an average diameter of 11.2 ± 9.9 nm were added at concentrations of 3 and 5 wt %. A decrease in the glass transition temperature (T g ) by ca. 20% corroborated the plasticizing effect of D-limonene compared to pure PLA. The incorporation of 5 wt % CaO in PLA composites promoted a ca. 15% decrease in T cc . Although CaO induced a lower Young's modulus and a lower thermal stability in nanocomposites, excellent antimicrobial performance was demonstrated. Both PLA/limonene and PLA/ limonene/CaO films reached 99.99% efficiency against Escherichia coli, regardless of the source of irradiation, D-limonene, and nanoparticle loading. Therefore, these nanocomposites establish significant progress in developing sustainable antimicrobial materials in the fields of medicine or food packaging.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Venus antiqua Clamshell-Derived Calcium Oxide Nanoparticles for the Preparation of PLA/d-Limonene/CaO Nanocomposites with Antimicrobial Properties

Moreno-Serna,

Oyarzún,

Ulloa-Flores

et al. 2023

ACS Sustainable Chem. Eng.

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“…Nanotechnology offers a promising avenue for developing scaffolds composed of fibers containing bioactive NPs in the context of regenerative endodontics [ 218 ]. These NPs possess unique attributes, such as small size, high surface area, increased solubility, and antibacterial activity, making them valuable for controlled release of bioactive agents [ 219 ].…”

Section: Nanomaterials Used For Pulpal Repair and Regenerationmentioning

confidence: 99%

Application of Nanomaterials in Endodontics

Afkhami,

Chen,

Walsh

et al. 2024

BME Front

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Recent advancements in nanotechnology have introduced a myriad of potential applications in dentistry, with nanomaterials playing an increasing role in endodontics. These nanomaterials exhibit distinctive mechanical and chemical properties, rendering them suitable for various dental applications in endodontics, including obturating materials, sealers, retro-filling agents, and root-repair materials. Certain nanomaterials demonstrate versatile functionalities in endodontics, such as antimicrobial properties that bolster the eradication of bacteria within root canals during endodontic procedures. Moreover, they offer promise in drug delivery, facilitating targeted and controlled release of therapeutic agents to enhance tissue regeneration and repair, which can be used for endodontic tissue repair or regeneration. This review outlines the diverse applications of nanomaterials in endodontics, encompassing endodontic medicaments, irrigants, obturating materials, sealers, retro-filling agents, root-repair materials, as well as pulpal repair and regeneration. The integration of nanomaterials into endodontics stands poised to revolutionize treatment methodologies, presenting substantial potential advancements in the field. Our review aims to provide guidance for the effective translation of nanotechnologies into endodontic practice, serving as an invaluable resource for researchers, clinicians, and professionals in the fields of materials science and dentistry.

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“…Besides BG's bioactive nature, a higher swelling ratio of BG‐containing fibers affects their rapid mineralization. [ 50 ] Similarly, BG nanoparticles (composition: 54% SiO 2 : 40% CaO : 6% P 2 O 5 (mol%), size: 27 nm, concentration: 5, 10, 20 wt%)‐incorporated PLA fibers were investigated by Canales et al [ 57 ] Agglomeration of the particles caused defects to increase with filler concentration. Using electrospun composite fibers with 5 and 20 wt% filler, the authors found that the presence of beads was most evident at concentrations greater than 10 wt%.…”

Section: Bioactive Glass‐containing Composite Fibersmentioning

confidence: 99%

Progress on Electrospun Composite Fibers Incorporating Bioactive Glass: An Overview

et al. 2023

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Electrospinning is a promising approach for the development of fibrous tissue engineering (TE) scaffolds suitable for hard and soft tissues. Apart from physicomechanical properties, electrospun fibers are required to incorporate bioactive cues to control cellular functions, including facilitating biomineralization and osteogenic differentiation in case of bone TE, as well as vascularization, to support successful tissue regeneration. In recent years, bioactive glass (BG) addition to electrospun biopolymer fibers has shown promising results in enhancing the properties of fibers, including the improvement of biological performance. In this article, a comprehensive overview of BG‐containing electrospun polymer composite fibers is presented, identifying the parameters that affect the mechanical properties as well as the biological response in vivo and in vitro. Subsequently, the effects of BG addition on the properties of the scaffolds are discussed. Recent developments in the fields of bone regeneration, wound healing, and drug delivery using BG‐containing electrospun fibrous scaffolds are described in detail. Essential aspects related to BG‐polymer composite fibers for translational research in TE are highlighted for future research in this field.

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Electrospun fibers of poly (lactic acid) containing bioactive glass and magnesium oxide nanoparticles for bone tissue regeneration

Cited by 32 publications

References 61 publications

Venus antiqua Clamshell-Derived Calcium Oxide Nanoparticles for the Preparation of PLA/d-Limonene/CaO Nanocomposites with Antimicrobial Properties

Venus antiqua Clamshell-Derived Calcium Oxide Nanoparticles for the Preparation of PLA/d-Limonene/CaO Nanocomposites with Antimicrobial Properties

Application of Nanomaterials in Endodontics

Progress on Electrospun Composite Fibers Incorporating Bioactive Glass: An Overview

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