Electrospun Fibrous Architectures for Drug Delivery, Tissue Engineering and Cancer Therapy

Abstract

The versatile electrospinning technique is recognized as an efficient strategy to deliver active pharmaceutical ingredients and has gained tremendous progress in drug delivery, tissue engineering, cancer therapy, and disease diagnosis. Numerous drug delivery systems fabricated through electrospinning regarding the carrier compositions, drug incorporation techniques, release kinetics, and the subsequent therapeutic efficacy are presented herein. Targeting for distinct applications, the composition of drug carriers vary from natural/synthetic polymers/blends, inorganic materials, and even hybrids. Various drug incorporation approaches through electrospinning are thoroughly discussed with respect to the principles, benefits, and limitations. To meet the various requirements in actual sophisticated in vivo environments and to overcome the limitations of a single carrier system, feasible combinations of multiple drug-inclusion processes via electrospinning could be employed to achieve programmed, multi-staged, or stimuli-triggered release of multiple drugs. The therapeutic efficacy of the designed electrospun drugeluting systems is further verified in multiple biomedical applications and is comprehensively overviewed, demonstrating promising potential to address a variety of clinical challenges.

Spun Biotextiles in Tissue Engineering and Biomolecules Delivery Systems

“…Degeneration of these cells results in changes in the extracellular matrix of the neural tissue that trigger a variety of clinical disorders. Since neurons cannot regenerate by themselves, restoration of their functions by means of biological and synthetic tools, processed in the form of fibrous scaffolds or biomolecule delivery systems, is a priority [139,140].…”

Electrospun polymer nanofibers for medical applications

“…Prowadzone są również badania nad możliwością zastosowania nanowłókien w terapii nowotworowej [54][55][56][57][58]. Przykładowo Yang i współpr.…”

Nanoparticles in an antibiotic-loaded nanomesh for drug delivery

“…This altered release has been previously documented for changes in bre texture, the pH differences of core and shell bres and bre shell thickness however to the author's knowledge, changes to release rates due to charged nanoparticles within the mesh has not been previously observed. 38,39 However, it has been shown that in core-shell electrospinning, positively charged drugs are found to migrate to the surface of the bres compared to neutral drugs which remain in the core. 40 This is due to the charge generation of the surface of the polymer during electrospinning.…”