Electrospun gelatin/nylon‐6 composite nanofibers for biomedical applications

Pant, Hem Raj; Kim, Cheol Sang

doi:10.1002/pi.4380

Cited by 25 publications

(10 citation statements)

References 31 publications

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“…Different methods of electrospinning such as coaxial, triaxial and emulsion) used to produce nanofiber witch used in tissue engineering applications [134][135][136]. Pant et al produced nanofiber composite from (gelatin/nylon-6) and studied effect of gelatin concentration on the efficiency of the produced nanofiber and used the product as scaffold to tissue engineering [137]. Yao et al prepared nanofiber by electrospun of PCL/PLA blend and studied the product to use it in tissue engineering application [138].…”

Section: Tissue Engineeringmentioning

confidence: 99%

Optimizing the electrospun parameters which affect the preparation of nanofibers

2019

Biointerface Res Appl Chem

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By electrospinning technique, nanofiber can be produced due to applied high potential voltage on polymer solution, leading to the formation of a jet from polymer solution that is collected on a collector in a nanofiber shape. In the last decade of the twentieth century with appearance of nanotechnology, work and publications on optimization of electrospinning and its applications increased exponentially. Morphology of produced nanofiber depends on three groups of parameters: 1- process conditions (applied voltage, flow rate and needle-to-collector distance) 2- solution conditions (concentration, molecular weight and degree of hydrolysis) 3- ambient conditions (temperature and humidity). Brief history from observation of change of the spherical shape of liquid droplet by the effect of the electrical force to conical shape, passing by Formhals patents to use portable electrospinning techniques will be mentioned. Because of various advantages of nanofiber such as high pore density and enormous surface area per volume ratio, there are vital applications based on nanofiber, for example water treatment, air filtration, sensors/biosensors, energy storage, tissue engineering, wound dressing and drug delivery system.

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Section: Tissue Engineeringmentioning

confidence: 99%

Optimizing the electrospun parameters which affect the preparation of nanofibers

2019

Biointerface Res Appl Chem

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“…Nevertheless, polyamides have been a biomaterial of choice for decades and they have been extensively developed for applications ranging from use as sutures 8,9 or membranes 10 to vascular applications 11 because of their toughness, low cost and outstanding biocompatibility 12 . Polyamides are also widely used in bone engineering as a consequence of the materials' high strength and flexibility, which is due to the extensive degrees of both crystallinity and hydrogen bonding [13][14][15][16][17][18][19][20][21] . Even though this may be useful in selected orthopaedic or vascular applications, these types of materials are typically difficult to process and functionalise, which has ultimately limited their performance in other applications.…”

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confidence: 99%

Elastomeric polyamide biomaterials with stereochemically tuneable mechanical properties and shape memory

Worch

Weems

et al. 2020

Nat Commun

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Biocompatible polymers are widely used in tissue engineering and biomedical device applications. However, few biomaterials are suitable for use as long-term implants and these examples usually possess limited property scope, can be difficult to process, and are nonresponsive to external stimuli. Here, we report a class of easily processable polyamides with stereocontrolled mechanical properties and high-fidelity shape memory behaviour. We synthesise these materials using the efficient nucleophilic thiol-yne reaction between a dipropiolamide and dithiol to yield an α,β − unsaturated carbonyl moiety along the polymer backbone. By rationally exploiting reaction conditions, the alkene stereochemistry is modulated between 35-82% cis content and the stereochemistry dictates the bulk material properties such as tensile strength, modulus, and glass transition. Further access to materials possessing a broader range of thermal and mechanical properties is accomplished by polymerising a variety of commercially available dithiols with the dipropiolamide monomer.

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“…15,16 Many reports show that GEL derivatives have an excellent potential to manage the adhesion, migration, growth and organization of the cells during wound healing process. [17][18][19] However, there is sometimes limitation due to low capacity to form fibers containing GEL. For that reason, incorporation of another polymer (synthetic polymer) is required to facilitate the electrospinning process.…”

Section: Introductionmentioning

confidence: 99%

Biphasic, tough composite core/shell PCL/PVA‐GEL nanofibers for biomedical application

Akbarzadeh

Pezeshki‐Modaress

Zandi

2019

J of Applied Polymer Sci

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Emulsion electrospinning using natural and synthetic polymers, including two dissimilar materials is a promising technique for nanofibers fabrication in a core/shell configuration for tissue engineering, controlled or sustained drug delivery and dressing applications. In this study, we designed and fabricated core/shell nanofibers based on polycaprolactone (PCL) as core material and poly(vinyl alcohol) (PVA)‐gelatin (GEL) blend as shell materials (PCL/PVA‐GEL) to achieve high mechanical properties, good cell growth, and proliferation via emulsion electrospinning. The effect of water to acetic acid ratio in the solvent system (8:2, 7:3, 6:4, 5:5) and also type and concentration (3, 5, 7 w/v %) of surfactant on emulsion stability and nanofibers morphology were investigated. The emulsion containing 2% Tween80 and 1% Span60 as surfactants were selected by considering the stability of emulsion and uniform fiber morphology. In the tensile strength and elongation at break, 53 and 8% increase in the crosslinked wet state of the PCL/PVA‐GEL nanofibers compared with PVA‐GEL nanofibers were observed respectively. The cell culture results indicated that the PCL/PVA‐GEL nanofibers surface has presented suitable interaction with fibroblast cells and cells attached and proliferated well on the fabricated substrate within 24 and 48 hours and also would be a good candidate for biomedical applications. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48713.

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Electrospun gelatin/nylon‐6 composite nanofibers for biomedical applications

Cited by 25 publications

References 31 publications

Optimizing the electrospun parameters which affect the preparation of nanofibers

Optimizing the electrospun parameters which affect the preparation of nanofibers

Elastomeric polyamide biomaterials with stereochemically tuneable mechanical properties and shape memory

Biphasic, tough composite core/shell PCL/PVA‐GEL nanofibers for biomedical application

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