Electrospun hydroxyapatite fibers from a simple sol–gel system

Franco, Pedro; João, C.F.C.; Silva, Jorge; Borges, João Paulo

doi:10.1016/j.matlet.2011.09.090

Cited by 63 publications

(37 citation statements)

References 17 publications

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“…These peaks are also exhibited by the electrospun scaffold, confirming the presence of HA after manufacturing. At 1019 cm , which is an impurity present in both pure HA as well as the electrospun scaffold [30,39]. The electrospinning technique is used to produce biomimetic nanofibers for tissue engineering applications since this technique can generate large surface area, interconnected pores, nanoscale dimensions and high porosity [40].…”

Section: Resultsmentioning

confidence: 99%

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In vitro osteoclast-like and osteoblast cells’ response to electrospun calcium phosphate biphasic candidate scaffolds for bone tissue engineering

Wepener

Richter

Papendorp

et al. 2012

J Mater Sci: Mater Med

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Successful long term bone replacement and repair remain a challenge today. Nanotechnology has makes it possible to alter materials' characteristics and therefore possibly improve on the material itself. In this study, biphasic (hydroxyapatite/β-tricalcium phosphate (HA/β-TCP)) nanobioceramic scaffolds were prepared by the electrospinning technique in order to mimic the extracellular matrix (ECM). Scaffolds were characterised by scanning electron microscopy (SEM) and Attentuated Total Reflectance Fourier Transform Infrared (ATR-FTIR). Osteoblasts as well as monocytes that were differentiated into osteoclast-like cells, were cultured separately on the biphasic bioceramic scaffolds for up to 6 days and the proliferation, adhesion and cellular response were determined using lactate dehydrogenase (LDH) cytotoxicity assay, nucleus and cytoskeleton dynamics, analysis of the cell cycle progression, measurement of the mitochondrial membrane potential and the detection of phosphatidylserine expression. SEM analysis of the biphasic bioceramic scaffolds revealed n ano fi be rs spun i n a m e sh -like sc af fold . Re sul ts indi c ate th at th e bi ph asi c bio ce ram ic electrospun scaffolds are biocompatible and have no significant negative effects on either osteoblasts or osteoclast-like cells in vitro.

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Section: Resultsmentioning

confidence: 99%

“…The technique uses electrical forces to produce fibers with diameters ranging from 2 nm to several micrometers [29,30]. An electrical field strength sufficient to overcome surface tension of the solution causes the droplets to elongate and eject very fine fibers.…”

Section: Fabrication Of Nano-biphasic Scaffoldsmentioning

confidence: 99%

In vitro osteoclast-like and osteoblast cells’ response to electrospun calcium phosphate biphasic candidate scaffolds for bone tissue engineering

Wepener

Richter

Papendorp

et al. 2012

J Mater Sci: Mater Med

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“…8, the a-axis and c-axis values were similar to the standard HAp (#24-0033: a¼ 9.432Å and c¼ 6.881 A). The determined amounts of unit cell volume of HAp showed that the experimental outcomes out of reaction (1) were not accompanied by a remarkable change in the unit cell volume under both milling atmospheres. Conversely, the obtained powders out of reaction (2) showed remarkable changes in the unit cell volume, particularly in HA7 and HA8 samples.…”

Section: Lattice Parametersmentioning

confidence: 93%

“…Generally, HAp is used in the coating of metallic implants, repairing of bone defects and bone augmentation due to its superior biocompatibility, osteoconductivity and bioactivity [1]. In addition, HAp and its substituted structures have also been served for drug delivery [2], gene therapy [3], chromatography [4] and waste water remediation [5].…”

Section: Introductionmentioning

confidence: 99%

Effect of milling parameters on the formation of nanocrystalline hydroxyapatite using different raw materials

Nasiri–Tabrizi

Fahami

Ebrahimi‐Kahrizsangi

2013

Ceramics International

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“…As mentioned above, the strength and the great merit of electrospinning technology are the ability to conduct fiber size, porosity, and shape using processing variables, such as applied voltage, polymer melt flow rate, capillary/collector distance, polymer/ceramic concentration, and solvent conductivity and volatility [94]. Recently, inorganic nanoparticles, such as HA, bioactive glass, and carbon nanotubes, have been widely co-electrospun into polymer nano fibers to enhance their mechanical properties and their biocompatibility response [101][102][103][104][105][106]. Although the bioceramic needle oriented in polymer fiber is challenging, but it is very important for enhancing the mechanical properties of the scaffolds.…”

Section: Electrospinningmentioning

confidence: 99%

Bioceramic Scaffolds

Amin¹,

Ewais²

2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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Millions of peoples in the world suffer from their bone damage tissues by disease or trauma. Every day, thousands of surgical procedures are performed to replace or repair these tissues. The availability of these tissues is a big problem, and their costs are expensive. The repair of these defects has become a major clinical and socioeconomic need with the increase of aging population and social development. The emerge of tissue engineering (TE) is considered as a glimmer of hope to contribute in solving this problem. It aims at the regeneration of damaged tissues with restoring and maintaining the function of human bone tissues using the combination of cell biology, materials science, and engineering principles. In this chapter, the current state of the tissue engineering in particular bioceramic scaffolds was discussed. Concept of tissue engineering was explored. Bioceramic scaffold materials, their processing techniques, challenges taken into consideration the design of the scaffolds, and their in-vitro and in-vivo studies were highlighted. The scaffolds with extra-functionalities such as drug release ability and clinical applications were mentioned.

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Electrospun hydroxyapatite fibers from a simple sol–gel system

Cited by 63 publications

References 17 publications

In vitro osteoclast-like and osteoblast cells’ response to electrospun calcium phosphate biphasic candidate scaffolds for bone tissue engineering

In vitro osteoclast-like and osteoblast cells’ response to electrospun calcium phosphate biphasic candidate scaffolds for bone tissue engineering

Effect of milling parameters on the formation of nanocrystalline hydroxyapatite using different raw materials

Bioceramic Scaffolds

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