Electrospun in-situ hybrid polyurethane/nano-TiO2 as wound dressings

Yan, Lidan; Si, Shaoxiong; Chen, Yi; Yuan, Tun; Fan, Haojun; Yao, Yongyi; Zhang, Qiyi

doi:10.1007/s12221-011-0207-0

Cited by 56 publications

(23 citation statements)

References 29 publications

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“…After 2 days ECF membranes gave higher MTT absorbance when compared with ECT and EBN but after 6 days the highest MTT absorbance was for EBN. All the membranes showed an increase in proliferation after 2 days and there was an even further increase in proliferation after 6 days suggesting that the porous nature of the membranes helped the cells to cling on to the surface 41…”

Section: Resultsmentioning

confidence: 97%

Structural characterization, mechanical properties, and in vitro cytocompatibility evaluation of fibrous polycarbonate urethane membranes for biomedical applications

Arjun

Ramesh

2012

J Biomedical Materials Res

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This paper reports the electrospinning of a series of oxidatively stable polycarbonate urethanes (PCU) [carbothane (ECT), bionate (EBN), and chronoflex (ECF)] using N,N-dimethyl formamide and tetrahydrofuran as the mixed solvent. The nonwoven membranes were characterized for their structure, performance, and compatibility with cells. Scanning electron microscope was utilized to study the structural morphology and fiber diameter. Microcomputed tomography (micro-CT) was used to characterize the 3D architecture, pore size distribution, and percentage porosity. All the membranes displayed a porous architecture with average fiber diameter in the range of 1.5-2 μm. Static mechanical tests on the membranes revealed that the tensile strength was greater than 7 MPa and the dynamic mechanical tests showed that the average storage modulus (E(i) ) is 2 MPa at 37°C. PCU membranes were subjected to accelerated in vitro degradation for 90 days in 20% hydrogen peroxide/0.1M cobalt chloride solution. Mechanical characterization of the membranes postdegradation confirmed a 64% reduction in tensile strength for EBN at the end of 90 days where as ECF and ECT did not show any significant mechanical property deterioration in the oxidative medium. Cytotoxicity of the membranes was evaluated using L929 fibroblast cells and the results indicated that all the PCU membranes were cytocompatible and showed good adherence to L929 cells. Accordingly, these results highlight the potential of these fibrous PCU membranes for biomedical applications but further in vivo correlation studies are required for better understanding of the biodegradation and biological efficacy.

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Section: Resultsmentioning

confidence: 97%

Structural characterization, mechanical properties, and in vitro cytocompatibility evaluation of fibrous polycarbonate urethane membranes for biomedical applications

Arjun

Ramesh

2012

J Biomedical Materials Res

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“…Based on their dual functions of waterproofness and permeability, the W&B nanofibrous membranes have been widely employed as wound dressing material recently . Compared with conventional wound dressing materials (e.g., cotton, flax), the W&B nanofibrous membranes present superior wound protection and moisture management capability by virtue of their easily adjustable pore structure …”

Section: Applications Of Electrospun Wandb Membranesmentioning

confidence: 99%

Waterproof and Breathable Electrospun Nanofibrous Membranes

et al. 2019

Macromol. Rapid Commun.

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Waterproof and breathable (W&B) membranes combine fascinating properties of resistance to liquid water penetration and transmitting of water vapor, playing a key role in addressing problems related to health, resources, and energy. Electrospinning is an efficient and advanced way to construct nanofibrous materials with easily tailored wettability and adjustable pore structure, therefore providing an ideal strategy for constructing W&B membranes. In this review, recent progress on electrospun W&B membranes is summarized, involving materials design and fabrication, basic properties of electrospun W&B membranes associated with waterproofness and breathability, as well as their applications. In addition, challenges and future trends of electrospun W&B membranes are discussed.

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“…The fibre quality was improved with the addition of the silver nanoparticles and fibre diameter was reduced due to an increase in the electrical conductivity of the solution. Other researchers have presented similar methods for silver nanoparticles [102] and iron oxide [103] and titanium dioxide [104].…”

Section: Novel Aspects Of Nanofibersmentioning

confidence: 99%

Electrospinning of Functional Nanofibers for Regenerative Medicine: From Bench to Commercial Scale

Mortimer¹,

Widdowson²,

Wright³

2018

Novel Aspects of Nanofibers

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Nanofibers are an important material for regenerative medicine as they have a commensurate morphology to that of the macromolecular matrix that supports and houses the growth of cells and tissues within the body. Electrospinning is widely used to fabricate non-woven structures on the nanoscale and the versatility of the technique has widened the application of nanofibers. This is due to ease of extending nanofiber functionality through the incorporation of active materials both during and after electrospinning. Recent developments in electrospinning devices, such as needle-free systems, have reinvigorated research as these advances now allow fabrication of nanofibers at commercial scales. The process of electrospinning has a number of operating parameters that are adjusted in optimisation to achieve ideal fibres and a multitude of instrument configurations can be adopted to achieve the required manufacture. The innate properties of nanofibers, such as high surface area to volume ratio, have many proven benefits for regenerative medicine and the chapter examines these before discussing how functionality can be further improved. Numerous materials can be incorporated in the manufacture of electrospun mats, however when choosing materials for regenerative medicine, biocompatibility and biodegradability are the dominant functionalities that are required.

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Electrospun in-situ hybrid polyurethane/nano-TiO2 as wound dressings

Cited by 56 publications

References 29 publications

Structural characterization, mechanical properties, and in vitro cytocompatibility evaluation of fibrous polycarbonate urethane membranes for biomedical applications

Structural characterization, mechanical properties, and in vitro cytocompatibility evaluation of fibrous polycarbonate urethane membranes for biomedical applications

Waterproof and Breathable Electrospun Nanofibrous Membranes

Electrospinning of Functional Nanofibers for Regenerative Medicine: From Bench to Commercial Scale

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