Electrospun Ketoprofen Sustained Release Nanofibers Prepared Using Coaxial Electrospinning

Abstract

The present study investigates the preparation of sustained release drug-loaded nanofibers using a modified coaxial electrospinning process where only solvent is exploited as sheath fluid. Drug-loaded ethyl cellulose (EC) nanofibers are successfully generated smoothly and continuously without any clogging through the coaxial process, in which ethanol is used as sheath fluid and EC and ketoprofen (KET) are taken as the filament-forming matrix and active pharmaceutical ingredient, respectively. Field-emission scanning electron microscopic observations demonstrated that the nanofibers diameter can be manipulated through the sheath fluid flow rate. The composite nanofibers are in essential a molecular solid dispersion of EC and KET based on the hydrogen bonding between them, as verified by XRD and ATR-FTIR results. In vitro dissolution tests show that KET in the nanofibers has a fine sustained release profile via a typical Fickian diffusion mechanism. The modified coaxial electrospinning with solvent as sheath fluid can be a useful tool for developing novel sustained release drug delivery nanofibers.

Blend electrospinning, coaxial electrospinning, and emulsion electrospinning techniques

“…Coaxial electrospinning was successfully used for delivery of broad spectrum of drugs. Core-shell fibers were prepared for delivery of antiinflammatory and analgesic drugs (i.e., ketoprofen [61,63,64], acetaminophen [65], ibuprofen [62,66,67]), antimicrobial drugs (i.e., metronidazole [68,69], amoxicillin [70], curcumin [71], ampicillin [72], ciprofloxacin [73], tetracycline [74,75], vancomycin [76]), and anticancer drugs (i.e., cis-platinum [77], doxorubicin [78], paclitaxel [79,80], and 5fluorouracyl [79,81]). Core/shell electrospinning is used for these molecules mainly because of prolongation of their release times.…”

Plasticized Drug‐Loaded Melt Electrospun Polymer Mats: Characterization, Thermal Degradation, and Release Kinetics

“…The achievable fast dissolution of the drug substance stems from the amorphous structure accompanied with high surface area of the fibrous mat consisting of hydrophilic polymer carrier, as it derives from the Noyes–Whitney equation . Besides enteral drug formulations, solvent‐based electrospinning has been used to elaborate tissue engineering scaffolds, wound dressings, implants, and transdermal drug delivery systems as well.…”

Electrospun Nanofibers: Shaping the Future of Controlled and Responsive Drug Delivery

“…Composite nanofibers DDS consisting of EC and hydrophilic polymers such as PVP [12,20] and polyethylene oxide (PEO) [81,85], as well as zein [86], have been reported. Lipophilic drugs, such as KET [80,87], IBU [85], and IMC [20], have good compatibility with EC, stabilizing the API in amorphous form. A benefit of using additional polymers with EC is the improved electrospinnability over EC alone.…”