Electrospun nanofiber drug delivery systems and recent applications: An overview

Muratoglu, Semsi; Inal, Murat; Akdag, Yagmur; Gulsun, Tugba; Sahin, Selma

doi:10.1016/j.jddst.2024.105342

Cited by 5 publications

(1 citation statement)

References 133 publications

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“…Electrospinning is notable for its rapid solvent evaporation owing to the high surface area of the nanofibers, which enables manufacturing at room temperature. This ability makes it a promising technique for applications in tissue engineering, regenerative medicine, preparing wound dressing materials, and synthesizing pharmaceutical formulations [1]. Generally, electrospinning involves applying high voltages ranging from 10 to 40 kV to the solution, but with a very low current in the microampere range; thus, energy consumption is also low.…”

Section: Introductionmentioning

confidence: 99%

Development of Polyvinyl Alcohol (PVA) Nanofibers Containing Cationic Lipid/siRNA Complexes via Electrospinning: The Impact of PVA Characterization

Kanamori,

Hara,

Yamazoe

et al. 2024

Nanomaterials

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This study aimed to develop polyvinyl alcohol (PVA) nanofibers encapsulating 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP)/siRNA complexes via electrospinning for the delivery of nucleic acid-based drugs. It also focused on the influence of the intrinsic properties of PVA on the efficacy of the system. PVA nanofibers, with diameters of 300–400 nm, were obtained, within which the siRNA remained intact and the DOTAP/siRNA complexes were uniformly dispersed. By incorporating DOTAP/siRNA complexes into the PVA nanofibers and assessing the impact of their RNA interference (RNAi) activity in A549-Luc cells, a stable inhibition of luciferase expression was observed. An examination of the nanofiber preparation process revealed that even when DOTAP or siRNA were added separately to the PVA solution without forming complexes, the RNAi effect was retained. The DOTAP/siRNA complexes released from the PVA nanofibers were internalized by the cells, with some PVA residues remaining on their surfaces. The significance of the degree of hydrolysis and polymerization of PVA on the performance of nanofibers was highlighted. Notably, PVA with a low degree of hydrolysis substantially enhanced RNAi effects, with luciferase expression inhibition reaching 91.5 ± 0.7%. Nanofibers made of PVA grades with anionic or cationic modifications were also evaluated, suggesting that they affect the efficacy of siRNA delivery. The insights obtained suggest avenues for future research to optimize drug delivery systems further.

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Section: Introductionmentioning

confidence: 99%

Development of Polyvinyl Alcohol (PVA) Nanofibers Containing Cationic Lipid/siRNA Complexes via Electrospinning: The Impact of PVA Characterization

Kanamori,

Hara,

Yamazoe

et al. 2024

Nanomaterials

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Electrospun Smart Hybrid Nanofibers for Multifaceted Applications

Nirwan,

Amarjargal,

Hengsbach

et al. 2024

Macromol. Rapid Commun.

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Smart electrospun hybrid nanofibers represent a cutting‐edge class of functional nanostructured materials with unique collective properties. This review aims to provide a comprehensive overview of the applications of smart electrospun hybrid nanofibers in the fields of energy, catalysis, and biomedicine. Electrospinning is a powerful tool to fabricate different types of nanofibers’ morphologies with precise control over structure and compositions. Through the incorporation of various functional components, such as nanoparticles, nanomoieties, and biomolecules, into the (co)polymer matrix, nanofibers can be tailored into smart hybrid materials exhibiting responsiveness to external stimuli such as temperature, pH, or light among others. Herein recent advancements in fabrication strategies for electrospun smart hybrid nanofibers are discussed, focusing on different electrospinning tools aimed at tailoring and developing smart hybrid nanofibers. These strategies include surface functionalization, doping, and templating, which enable fine‐tuning of mechanical strength, conductivity, and biocompatibility. The review explores the challenges and recent progress in the development of smart hybrid nanofibers. Issues such as scalability, reproducibility, biocompatibility, and environmental sustainability are identified as key for improvement. Furthermore, the applications of smart nanofibers in biomedicine, environment, energy storage, and smart textiles underscore their potential to address the challenges in development of nanostructured materials for emerging technologies.

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