Electrospun nanofibers: a promising horizon toward the detection and treatment of cancer

Asghari, Sahar; Rezaei, Zahra; Mahmoudifard, Matin

doi:10.1039/c9an01987a

Cited by 28 publications

(14 citation statements)

References 114 publications

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“…Among the various methods in producing the incorporation of different polymers, electrospinning has recently emerged as one of the most efficient and successful techniques due to its wide applications for fabrication of continuous fibers with diameters in a nanometer scale [ 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. Electrospinning can be classified into different approaches such as needleless electrospinning, uniaxial electrospinning, coaxial electrospinning, and multifluidic electrospinning [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Tunable Mechanical and Electrical Properties of Coaxial Electrospun Composite Nanofibers of P(VDF-TrFE) and P(VDF-TrFE-CTFE)

Lam

Hsiao

et al. 2021

IJMS

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The coaxial core/shell composite electrospun nanofibers consisting of relaxor ferroelectric P(VDF-TrFE-CTFE) and ferroelectric P(VDF-TrFE) polymers are successfully tailored towards superior structural, mechanical, and electrical properties over the individual polymers. The core/shell-TrFE/CTFE membrane discloses a more prominent mechanical anisotropy between the revolving direction (RD) and cross direction (CD) associated with a higher tensile modulus of 26.9 MPa and good strength-ductility balance, beneficial from a better degree of nanofiber alignment, the increased density, and C-F bonding. The interfacial coupling between the terpolymer P(VDF-TrFE-CTFE) and copolymer P(VDF-TrFE) is responsible for comparable full-frequency dielectric responses between the core/shell-TrFE/CTFE and pristine terpolymer. Moreover, an impressive piezoelectric coefficient up to 50.5 pm/V is achieved in the core/shell-TrFE/CTFE composite structure. Our findings corroborate the promising approach of coaxial electrospinning in efficiently tuning mechanical and electrical performances of the electrospun core/shell composite nanofiber membranes-based electroactive polymers (EAPs) actuators as artificial muscle implants.

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Section: Introductionmentioning

confidence: 99%

Tunable Mechanical and Electrical Properties of Coaxial Electrospun Composite Nanofibers of P(VDF-TrFE) and P(VDF-TrFE-CTFE)

Lam

Hsiao

et al. 2021

IJMS

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“…However, it takes some effort to disperse effectively the CNTs in the composites due to ¶- ¶ interactions and strong van der Waals forces between the tubes that cause CNT aggregation in the composites [94]. Therefore, CNT hybrids are used to aid CNTs in disperse inside polymer matrices [95]. A research group decided to improve CNTs functionality and prevent aggregation in composites by treatment with VB 1 [96].…”

Section: Othersmentioning

confidence: 99%

Retrospective, Perspective and Prospective of B-Complex Vitamins: Encapsulation of Vitamins and Release from Vitamin-Loaded Polymers

Parın¹

2022

B-Complex Vitamins - Sources, Intakes and Novel Applications

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Vitamins are regarded as vital nutrients because, when combined, they performed hundreds of functions in the body. They strengthen bones, heal wounds, and boost your immune system. In addition, they transform food into energy and heal cellular damage. In this regard, B-complex vitamins, such as thiamine, riboflavin, and niacin are soluble vitamins that serve as coenzymes in energy metabolism enzymatic activities which building blocks of a healthy body. However, B-complex vitamins are sensitive to light, pH conditions, and temperature. Consequently, they must be encapsulated before they may be used in pharmaceuticals. Recently, it is mainly focused on reducing drug degradation or loss, increase drug bioavailability, limit adverse effects, and improve drug accumulation in the targeted location. To maintain optimum bioavailability during a defined term of therapy, the fraction of drug dosage released from a controlled release product must be significant enough to adjust for the quantity of active drug metabolized and/or eliminated from the body over the same period. Drug release systems also aim to increase the effectiveness of the drug and treat the damaged area. In this chapter, it is aimed to study the production of the vitamin-loaded polymer systems in various forms, such as micro/nanoparticles, micelle, hydrogel, liposome, and nanofiber, as well as release studies in pharmaceutical and biomedical applications.

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“…The set-up protocols serve bioengineers with the control over the individual fiber size, porosity, alignment, and mechanical properties which are critical in guiding cellular attachment and orientation and eliciting optimal cellular responses [36,37]. For detailed discussions on the methodology of electrospinning in general biomedical applications, please refer to these reviews [29,34,[38][39][40][41][42][43][44][45][46][47][48][49][50][51][52]. For reviews specific to cardiac applications, the following reviews are recommended [29,34,[39][40][41].…”

Section: Electrospinning Of Microfibrous Scaffoldsmentioning

confidence: 99%

Mechanical Considerations of Electrospun Scaffolds for Myocardial Tissue and Regenerative Engineering

Nguyen‐Truong

Wang

2020

Bioengineering

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Biomaterials to facilitate the restoration of cardiac tissue is of emerging importance. While there are many aspects to consider in the design of biomaterials, mechanical properties can be of particular importance in this dynamically remodeling tissue. This review focuses on one specific processing method, electrospinning, that is employed to generate materials with a fibrous microstructure that can be combined with material properties to achieve the desired mechanical behavior. Current methods used to fabricate mechanically relevant micro-/nanofibrous scaffolds, in vivo studies using these scaffolds as therapeutics, and common techniques to characterize the mechanical properties of the scaffolds are covered. We also discuss the discrepancies in the reported elastic modulus for physiological and pathological myocardium in the literature, as well as the emerging area of in vitro mechanobiology studies to investigate the mechanical regulation in cardiac tissue engineering. Lastly, future perspectives and recommendations are offered in order to enhance the understanding of cardiac mechanobiology and foster therapeutic development in myocardial regenerative medicine.

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Electrospun nanofibers: a promising horizon toward the detection and treatment of cancer

Abstract: Potential application of electrospun nanofibrous membranes in cancer detection and treatment.

Cited by 28 publications

References 114 publications

Tunable Mechanical and Electrical Properties of Coaxial Electrospun Composite Nanofibers of P(VDF-TrFE) and P(VDF-TrFE-CTFE)

Tunable Mechanical and Electrical Properties of Coaxial Electrospun Composite Nanofibers of P(VDF-TrFE) and P(VDF-TrFE-CTFE)

Retrospective, Perspective and Prospective of B-Complex Vitamins: Encapsulation of Vitamins and Release from Vitamin-Loaded Polymers

Mechanical Considerations of Electrospun Scaffolds for Myocardial Tissue and Regenerative Engineering

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