Electrospun nanofibers: a promising paradigm for biomedical applications

Kulkarni, Deepak; Giram, Prabhanjan; Mahore, Jayashri; Kapare, Harshad; Panzade, Prabhakar

doi:10.1080/00914037.2024.2335173

Cited by 4 publications

(1 citation statement)

References 127 publications

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“…Two principal advantages are achieved when these components are blended. On the one hand, the proper polyesters' compositions are more successfully engaged in biomedical applications [21], modern therapy for drug delivery platform design [22], packaging industrial coatings [23], and in many other areas. On the other hand, a series of the drawbacks inherent to individual blend constituents (PLA and PCL) can be successfully eliminated by the blend fabrication.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Polylactide—Poly(ε-Caprolactone) Fibers: Structure Characterization and Segmental Dynamic Response

Karpova,

Olkhov,

Varyan

et al. 2024

Polymers

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Electrospun ultrathin fibers based on binary compositions of polylactide (PLA) and poly(ε-caprolactone) (PCL) with the various content from the polymer ratio from 0/100 to 100/0 have been explored. Combining thermal (DSC) and spectropy (ESR) techniques, the effect of biopolymer content on the characteristics of the crystal structure of PLA and PCL and the rotative diffusion of the stable TEMPO radical in the intercrystallite areas of PLA/PCL compositions was shown. It was revealed that after PLA and PCL blending, significant changes in the degree of crystallinity of PLA, PCL segment mobility, sorption of the Tempo probe, as well as its activation energy of rotation in the intercrystalline areas of PLA/PCL fibers, were evaluated. The characteristic region of biopolymers’ composition from 50/50 to 30/70% PLA/PCL blend ratio was found, where the inversion transition of PLA from dispersive medium to dispersive phase where an inversion transition is assumed when the continuous medium of the PLA transforms into a discrete phase. The performed studies made it possible, firstly, to carry out a detailed study of the effect of the system component ratio on the structural and dynamic characteristics of the PLA/PCL film material at the molecular level.

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Section: Introductionmentioning

confidence: 99%

Electrospun Polylactide—Poly(ε-Caprolactone) Fibers: Structure Characterization and Segmental Dynamic Response

Karpova,

Olkhov,

Varyan

et al. 2024

Polymers

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Review on electrospray nanoparticles for drug delivery: Exploring applications

Patel,

Haemmerich

2024

Polymers for Advanced Techs

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Electrospraying has emerged as a versatile technique in the pharmaceutical field due to its potential in drug delivery and formulation. With its advantages of cost‐effectiveness, reproducibility, ease of operation, and scalability, electrospraying offers numerous benefits for pharmaceutical applications. Notably, the production of nanoparticles using electrospraying provides unique properties, including small size, drug encapsulation capabilities, biocompatibility, and scalability. Electrospray nanoparticles have demonstrated significant promise in various drug delivery routes, such as oral and topical administration. These nanoparticles enhance drug stability, protection, and permeability, effectively overcoming limitations associated with these routes. Moreover, electrospray nanoparticles have proven valuable in targeted drug delivery, improving drug bioavailability and efficacy. Their ability to penetrate tissues and cells enables enhanced drug delivery to specific sites within the body. Additionally, electrospray nanoparticles can be tailored with targeting ligands or responsive components for controlled release and combination therapy, exhibiting successful applications in cancer treatment and neurological disorders. Therefore, electrospray nanoparticle technology shows great promise in biomedical applications, offering a versatile platform for targeted drug delivery and therapeutic interventions. This comprehensive review examines the various drug delivery applications of electrospraying and provides insights into its possibilities and challenges. The paper discusses the principles, methods, and parameters of electrospraying, while also exploring its use in fabricating drug delivery systems, addressing poorly soluble drugs. By synthesizing the findings from multiple studies, this review offers a comprehensive understanding of electrospraying's current state and potential in the pharmaceutical industry.

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