Electrospun nanofibers for drug delivery

Asmatulu, Ramazan; Khan, Waseem S.

doi:10.1016/b978-0-12-813914-1.00003-1

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…Electrospun fibrous meshes can also be used in conventional transdermal drug delivery systems (TDDs) and transdermal patches, since they can carry a wide range of pharmaceutical ingredients, including antitumor drugs, antibiotics, anti-inflammatory drugs, nucleic acids and proteins [11]. The mechanisms of drug release can be adjusted by modifying the electrospinning parameters and, consequently, fiber properties [12,13].…”

Section: Introductionmentioning

confidence: 99%

A Straightforward Method to Produce Multi-Nanodrug Delivery Systems for Transdermal/Tympanic Patches Using Electrospinning and Electrospray

Azimi,

Ricci,

Macchi

et al. 2023

Polymers

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The delivery of drugs through the skin barrier at a predetermined rate is the aim of transdermal drug delivery systems (TDDSs). However, so far, TDDS has not fully attained its potential as an alternative to hypodermic injections and oral delivery. In this study, we presented a proof of concept of a dual drug-loaded patch made of nanoparticles (NPs) and ultrafine fibers fabricated by using one equipment, i.e., the electrospinning apparatus. Such NP/fiber systems can be useful to release drugs locally through the skin and the tympanic membrane. Briefly, dexamethasone (DEX)-loaded poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBHV) fiber meshes were decorated with rhodamine (RHO)-loaded poly(lactic-co-glycolic acid) (PLGA) NPs, with RHO representing as a second drug model. By properly tuning the working parameters of electrospinning, DEX-loaded PHBHV fibers (i.e., by electrospinning mode) and RHO-loaded PLGA NPs (i.e., by electrospray mode) were successfully prepared and straightforwardly assembled to form a TDDS patch, which was characterized via Fourier transform infrared spectroscopy and dynamometry. The patch was then tested in vitro using human dermal fibroblasts (HDFs). The incorporation of DEX significantly reduced the fiber mesh stiffness. In vitro tests with showed that HDFs were viable for 8 days in contact with drug-loaded samples, and significant signs of cytotoxicity were not highlighted. Finally, thanks to a beaded structure of the fibers, a controlled release of DEX from the electrospun patch was obtained over 4 weeks, which may accomplish the therapeutic objective of a local, sustained and prolonged anti-inflammatory action of a TDDS, as is requested in chronic inflammatory conditions, and other pathological conditions, such as in sudden sensorineural hearing loss treatment.

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Section: Introductionmentioning

confidence: 99%

A Straightforward Method to Produce Multi-Nanodrug Delivery Systems for Transdermal/Tympanic Patches Using Electrospinning and Electrospray

Azimi,

Ricci,

Macchi

et al. 2023

Polymers

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“…An interesting application for 3D printing is the formation of patches for topical and transdermal applications, for the prolonged and sustainable delivery of the drugs. Over the years, various techniques have been utilized for the preparation of patches, including solvent casting [3], freeze-drying [4], and electrospinning [5], while the main key properties of their design are breathability, flexibility, good mechanical properties, and biocompatibility [6].…”

Section: Introductionmentioning

confidence: 99%

Novel 3D-Printed Dressings of Chitosan–Vanillin-Modified Chitosan Blends Loaded with Fluticasone Propionate for Treatment of Atopic Dermatitis

Michailidou

Bikiaris

2022

Pharmaceutics

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In the present study, the blends of CS and Vanillin–CS derivative (VACS) were utilized for the preparation of printable inks for their application in three-dimensional (3D) printing procedures. Despite the synergic interaction between the blends, the addition of ι-carrageenan (iCR) as a thickening agent was mandatory. Their viscosity analysis was conducted for the evaluation of the optimum CS/VACS ratio. The shear thinning behavior along with the effect of the temperature on viscosity values were evident. Further characterization of the 3D-printed structures was conducted. The effect of the CS/VACS ratio was established through swelling and contact angle measurements. An increasing amount of VACS resulted in lower swelling ability along with higher hydrophobicity. Fluticasone propionate (FLU), a crystalline synthetic corticosteroid, was loaded into the CS/VACS samples. The drug was loaded in its amorphous state, and consequently, its in vitro release was significantly enhanced. An initial burst release, followed by a sustained release profile, was observed.

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