Electrospun nanofibers for the delivery of active drugs through nasal, oral and vaginal mucosa: Current status and future perspectives

Sofi, Hasham S.; Abdal‐hay, Abdalla; Ivanovski, Sašo; Zhang, Yu Shrike; Sheikh, Faheem A.

doi:10.1016/j.msec.2020.110756

Cited by 92 publications

(55 citation statements)

References 144 publications

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“…Recently, electrospinning has been considered as viable in the encapsulation of bioactive agents to improve their biocompatibility and bioaccessibility, including hydrophobic small substances, hydrophilic small substances and macromolecular active substances (e.g., enzymes, active proteins, probiotics) [ 86 ]. This technology has wide applications in filtration, wound dressing [ 87 ], drug delivery [ 88 ], tissue engineering [ 89 ], protective clothing, etc. However, there are manufacturing difficulties associated with the bioactive electrospun nanofibers.…”

Section: Electrospun Ultrafine Fibers For Reusable Face Masksmentioning

confidence: 99%

Electrospun ultrafine fibers for advanced face masks

Zhang

et al. 2021

Materials Science and Engineering: R: Reports

146

119

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The outbreak of Coronavirus Disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has triggered great global public health concern. Face masks are essential tools to reduce the spread of SARS-CoV-2 from human to human. However, there are still challenges to prolong the serving life and maintain the filtering performance of the current commercial mask. Filters composed of ultrafine fibers with diameter down to tens of nanometers have the potential to physically block viruses. With adjustable composition and nanostructures, the electrospun ultrafine fiber filter is possible to achieve other necessary functions beyond virus blocking, such as antiviral, transparent, and degradable, making it an important part of fighting the epidemic. In this review, beginning with the basic information of the viruses, we summarize the knowledge of masks and respirators, including the filtering mechanism, structure, classification, and standards. We further present the fabrication method, filtering performance, and reusable potential of electrospun ultrafine fiber-based masks. In the end, we discuss the development directions of ultrafine fibers in protective devices, especially their new functional applications and possible contributions in the prevention and control of the epidemic.

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Section: Electrospun Ultrafine Fibers For Reusable Face Masksmentioning

confidence: 99%

Electrospun ultrafine fibers for advanced face masks

Zhang

et al. 2021

Materials Science and Engineering: R: Reports

146

119

View full text Add to dashboard Cite

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“…Besides, high drug loading ability, permeability and flexibility, exclusive surface topology, biomimetic properties, controllable morphology, distinct and abundant raw materials, suitable adhesion, and controlled mechanical properties also make these nanostructured materials quite interesting for drug-delivery applications. [1][2][3]10,[14][15][16][17][18][19] Polymeric nanofibers have been applied as DDS for delivery of antibiotic, [5,20] antimicrobial agents, [15,21] vitamins, [22] antiinflammatory, [23] analgesic, [2] antidepressant, [24] anticancer, [3] antimycotic [25] and anthelmintic, [14] as well as hormones. [8,10,17] Desirable release profile (ie, immediate, sustained, biphasic, or delayed) from drug-loaded polymeric nanofibers could be easily achieved by the choice of the polymer/solvent system and nanofiber fabrication method.…”

Section: Introductionmentioning

confidence: 99%

Electrospun progesterone‐loaded cellulose acetate nanofibers and their drug sustained‐release profiles

Soares

Machado

Diniz

et al. 2020

Polymer Engineering & Sci

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Novel cellulose acetate (CA) nanofibers incorporated with hormone progesterone (P4) were prepared by electrospinning and its potential as a controlled release system for medicine and veterinary was evaluated by controlled release essay. The morphology, thermal behavior, and structure of P4‐loaded CA nanofibers were characterized by scanning electron microscopy, differential scanning calorimetry, and Fourier‐transform infrared spectroscopy. The analyses revealed that the incorporation of P4 increased nanofibers' diameter from around 340 to 892 nm to 8% w/w P4‐loaded CA nanofibers. Furthermore, P4 has demonstrated high interaction with CA affecting its crystalline structure, since pure CA nanofibers presented 67.23% of crystallinity while P4‐loaded CA nanofibers where amorphous. Ultimately, the drug release essay demonstrated a two‐stage profile, and regarding release kinetics, the samples evidenced a diffusion mechanism depending on P4 concentration in the nanofiber.

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“…Drug delivery systems based on nanofibers have some advantages, including masking the taste of bitter drugs, a simple fabrication process, and superior pharmaceutical and pharmacokinetic performances when compared with regular delivery systems. Moreover, adhesive nanofibers have many characteristics, such as rapid dissolution, controlled release, and delayed action of drugs [ 159 ]. The drug release kinetics of nanofibers can be regulated by the selection of polymer, calixarene, cellulose, and other matrix materials, as well as the preparation process of nanofibers.…”

Section: Recent Advances and Future Prospectsmentioning

confidence: 99%

Current Perspective on Nasal Delivery Systems for Chronic Rhinosinusitis

2021

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Chronic rhinosinusitis is an upper respiratory disease during which topical drug treatment via the nasal cavity is the most actively utilized therapeutic strategy. In addition to steroids, antibiotics, and antifungal agents, which are widely used in clinical practice, research on novel topical agents to improve the bacterial biofilm or mucociliary clearance remains ongoing. Moreover, owing to the complex structure of the nasal cavity, the effects of nasal drug delivery vary depending on factors related to delivery fluid dynamics, including device, volume, and compounds. In this article, we review methods and compounds that have been applied to chronic rhinosinusitis management and introduce recent advances and future perspectives in nasal drug delivery for upper respiratory diseases.

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Electrospun nanofibers for the delivery of active drugs through nasal, oral and vaginal mucosa: Current status and future perspectives

Cited by 92 publications

References 144 publications

Electrospun ultrafine fibers for advanced face masks

Electrospun ultrafine fibers for advanced face masks

Electrospun progesterone‐loaded cellulose acetate nanofibers and their drug sustained‐release profiles

Current Perspective on Nasal Delivery Systems for Chronic Rhinosinusitis

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