Electrospun nanofibers for tissue engineering

Asmatulu, Ramazan; Khan, Waseem S.

doi:10.1016/b978-0-12-813914-1.00011-0

Cited by 5 publications

(1 citation statement)

References 83 publications

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“…The transformation of polymer dispersion into NF by the ES technique is affected by several parameters, including (a) the polymer dispersion properties, such as surface tension, conductivity/charge density, and viscosity, which are determined by the polymer molecular weight and polymer concentration and volatility of solvents; (b) processing condition, such as the field strength/applied voltage, flow rate, the distance between the tip and the collector, the needle tip design and placement, collector composition, geometry and take up the velocity of the collector, and (c) ambient parameters, such as temperature, humidity, and atmospheric pressure [20][21][22][23]. As long as the polymer can be ES into NF, ideal targets would be: (1) the diameter of the fibers to be consistent and controllable, (2) the fiber surface to be defect-free or defect-controllable, and (3) continuous single NF to be collectible.…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of pH-Dependent Cellulose Acetate Phthalate Nanofibers by Electrospinning Technique

et al. 2021

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The aim of this work was to obtain pH-dependent nanofibers with an electrospinning technique as a novel controlled release system for the treatment of periodontal disease (PD). Cellulose acetate phthalate (CAP) was selected as a pH-sensitive and antimicrobial polymer. The NF was optimized according to polymeric dispersion variables, polymer, and drug concentration, and characterized considering morphology, diameter, entrapment efficiency (EE), process efficiency (PE), thermal properties, and release profiles. Two solvent mixtures were tested, and CHX-CAP-NF prepared with acetone/ethanol at 12% w/v of the polymer showed a diameter size of 934 nm, a uniform morphology with 42% of EE, and 55% of PE. Meanwhile, CHX-CAP-NF prepared with acetone/methanol at 11% w/v of polymer had a diameter of 257 nm, discontinuous nanofiber morphology with 32% of EE, and 40% of PE. EE and PE were dependent on the polymer concentration and the drug used in the formulation. Studies of differential scanning calorimetry (DSC) showed that the drug was dispersed in the NF matrix. The release profiles of CHX from CHX-CAP-NF followed Fickian diffusion dependent on time (t0.43−0.45), suggesting a diffusion–erosion process and a matrix behavior. The NF developed could be employed as a novel drug delivery system in PD.

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