Electrospun nanofibrous materials for wound healing applications

Balusamy, Brabu; Anitha, S.; Uyar, Tamer

doi:10.1016/b978-0-08-101022-8.00012-0

Cited by 16 publications

(11 citation statements)

References 60 publications

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“…The set-up protocols serve bioengineers with the control over the individual fiber size, porosity, alignment, and mechanical properties which are critical in guiding cellular attachment and orientation and eliciting optimal cellular responses [ 36 , 37 ]. For detailed discussions on the methodology of electrospinning in general biomedical applications, please refer to these reviews [ 29 , 34 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ]. For reviews specific to cardiac applications, the following reviews are recommended [ 29 , 34 , 39 , 40 , 41 ].…”

Section: Electrospinning Of Microfibrous Scaffoldsmentioning

confidence: 99%

Mechanical Considerations of Electrospun Scaffolds for Myocardial Tissue and Regenerative Engineering

Nguyen‐Truong

Wang

2020

Bioengineering

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Biomaterials to facilitate the restoration of cardiac tissue is of emerging importance. While there are many aspects to consider in the design of biomaterials, mechanical properties can be of particular importance in this dynamically remodeling tissue. This review focuses on one specific processing method, electrospinning, that is employed to generate materials with a fibrous microstructure that can be combined with material properties to achieve the desired mechanical behavior. Current methods used to fabricate mechanically relevant micro-/nanofibrous scaffolds, in vivo studies using these scaffolds as therapeutics, and common techniques to characterize the mechanical properties of the scaffolds are covered. We also discuss the discrepancies in the reported elastic modulus for physiological and pathological myocardium in the literature, as well as the emerging area of in vitro mechanobiology studies to investigate the mechanical regulation in cardiac tissue engineering. Lastly, future perspectives and recommendations are offered in order to enhance the understanding of cardiac mechanobiology and foster therapeutic development in myocardial regenerative medicine.

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Section: Electrospinning Of Microfibrous Scaffoldsmentioning

confidence: 99%

Mechanical Considerations of Electrospun Scaffolds for Myocardial Tissue and Regenerative Engineering

Nguyen‐Truong

Wang

2020

Bioengineering

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“…By combining the properties of polyurethanes and electrospinning, there is the possibility to obtain scaffolds that can mimic the native extracellular matrix of biological tissue. Therefore, due to the large surface area and porous network structure, the electrospun polyurethane nanofibers can be used effectively for many biomedical applications such as in wound dressing preparation [26,27], drug delivery systems [28], tissue engineering [29,30], etc.…”

Section: Introductionmentioning

confidence: 99%

“…Although literature shows a high number of studies [24][25][26][27][28][29][30], the possibility for combining the properties of the aforementioned compounds with the purpose of creating a novel or improved generation of fibrous scaffolds is still attractive. To realize this, it is important to study the interaction between the structures used to obtain the polymeric matrices, in order to prepare further new scaffolds for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Nanofibrous Hydroxypropyl Cellulose and β-Cyclodextrin Polyurethane Composite Mats

Grădinaru¹,

Barbălată-Mândru²,

Drobotă³

et al. 2020

Nanomaterials

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A series of nanofibrous composite mats based on polyurethane urea siloxane (PUUS), hydroxypropyl cellulose (HPC) and β-cyclodextrin (β-CD) was prepared using electrospinning technique. PUUS was synthesized by two steps solution polymerization procedure from polytetramethylene ether glycol (PTMEG), dimethylol propionic acid (DMPA), 4,4 -diphenylmethane diisocyanate (MDI) and 1,3-bis-(3-aminopropyl) tetramethyldisiloxane (BATD) as chain extender. Then, the composites were prepared by blending PUUS with HPC or βCD in a ratio of 9:1 (w/w), in 15% dimethylformamide (DMF). The PUUS and PUUS based composite solutions were used for preparation of nanofibrous mats. In order to identify the potential applications, different techniques were used to evaluate the chemical structure (Fourier transform infrared-attenuated total reflectance spectroscopy-FTIR-ATR), morphological structure (Scanning electron microscopy-SEM and Atomic force microscopy-AFM), surface properties (contact angle, dynamic vapors sorption-DVS), mechanical characteristics (tensile tests), thermal (differential scanning calorimetry-DSC) and some preliminary tests for biocompatibility and microbial adhesion.

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“…Owing to the potential beneficial features, the electrospun nanofibers have been enormously employed in various sectors including energy [9][10][11][12][13], environmental [9,[10][11][12][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] and biomedical [9,12,[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] applications. Especially, appreciable efforts have been paved towards designing and development of various elect- rospun nanofibers for wound healing and tissue engineering applications that brought the fields a step forward [31,34,42,[44][45][46][47]…”

Section: Introductionmentioning

confidence: 99%

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

Balusamy

Anitha

Uyar

2020

Hacettepe Journal of Biology and Chemistry

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E lektro-eğirme yöntemi ile üretilen nanolifler, son yıllarda nanofibröz yapı iskelelerinin geliştirilmesinde büyük ilgi gördü ve biyomimetik yapıları nedeniyle farklı biyomedikal uygulamalarda kullanıldı. Özellikle, elektro-eğirme yöntemi ile üretilen nanolifler doğal hücre dışı matris (ECM), birbirine bağlı gözenekler, geniş yüzey alanı, işlevselleştirme kolaylığı ve hücre adezyonunu, farklılaşmasını ve proliferasyon davranışını etkilemede büyük önem taşıyan mekanik performans dahil olmak üzere birçok faydalı özellik sergiler. Bugüne kadar, çok çeşitli yararlı özellikleri kabul eden bu nanolifler, yara örtüsü ve doku mühendisliği uygulamalarında kullanılmıştır. Bu derlemede, çeşitli malzemelerin ve yaklaşımların kullanımını gösteren birkaç temsili örneklerle bu alanlarda çeşitli çabaların yapıldığını özetlemektedir. Ayrıca, klinik faz transferine ilişkin gelecekteki yön endişeleri tartışılmıştır. Anahtar Kelimeler Elektro-eğirme, nanolif, yara örtüsü, doku mühendisliği.

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Electrospun nanofibrous materials for wound healing applications

Cited by 16 publications

References 60 publications

Mechanical Considerations of Electrospun Scaffolds for Myocardial Tissue and Regenerative Engineering

Mechanical Considerations of Electrospun Scaffolds for Myocardial Tissue and Regenerative Engineering

Preparation and Evaluation of Nanofibrous Hydroxypropyl Cellulose and β-Cyclodextrin Polyurethane Composite Mats

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

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