Electrospun nanofibrous membranes incorporating an imidazole-appended p-phenylene-Cu(<scp>ii</scp>) ensemble as fluoroprobes for the detection of His-proteins

Kim, Ka Young; Jung, Sung Ho; Jung, Jong Hwa

doi:10.1039/c5tb01584g

Cited by 6 publications

(6 citation statements)

References 37 publications

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“…In 2015, Kim et al. [ 26 ] have leveraged the concept of AIE to synthesize TPE‐imidazole‐based Cu(II) electrospun nanofibrous membrane (termed IP‐Cu‐NMs) as a portable chemosensor for histidine (His) and His‐proteins, see Figure 8 a . The emission intensity of AIE‐active nanofibers was found to decrease when the Cu(II) concentration increases.…”

Section: Aie Electrospun Nanofiber Compositesmentioning

confidence: 99%

“…This transformation switches on its luminescence through the interaction between two neighboring rings of TPE‐imidazole, hence restricting the rotational motion of phenylene rings. [ 26 ]…”

Section: Aie Electrospun Nanofiber Compositesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Stimuli‐Responsive Electrospun Fluorescent Fibers Augmented with Aggregation‐Induced Emission (AIE) for Smart Applications

Kachwal

Tan

2022

Advanced Science

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This review addresses the latest advancements in the integration of aggregation-induced emission (AIE) materials with polymer electrospinning, to accomplish fine-scale electrospun fibers with tunable photophysical and photochemical properties. Micro-and nanoscale fibers augmented with AIE dyes (termed AIEgens) are bespoke composite systems that can overcome the limitation posed by aggregation-caused quenching, a critical deficiency of conventional luminescent materials. This review comprises three parts. First, the reader is exposed to the basic concepts of AIE and the fundamental mechanisms underpinning the restriction of intermolecular motions. This is followed by an introduction to electrospinning techniques pertinent to AIE-based fibers, and the core parameters for controlling fiber architecture and resultant properties. Second, exemplars are drawn from latest research to demonstrate how electrospun nanofibers and porous films incorporating modified AIEgens (especially tetraphenylethylene and triphenylamine derivatives) can yield enhanced photostability, photothermal properties, photoefficiency (quantum yield), and improved device sensitivity. Advanced applications are drawn from several promising sectors, encompassing optoelectronics, drug delivery and biology, chemosensors and mechanochromic sensors, and innovative photothermal devices, among others. Finally, the outstanding challenges together with potential opportunities in the nascent field of electrospun AIE-active fibers are presented, for stimulating frontier research and explorations in this exciting field.

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Section: Aie Electrospun Nanofiber Compositesmentioning

confidence: 99%

Section: Aie Electrospun Nanofiber Compositesmentioning

confidence: 99%

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Stimuli‐Responsive Electrospun Fluorescent Fibers Augmented with Aggregation‐Induced Emission (AIE) for Smart Applications

Kachwal

Tan

2022

Advanced Science

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“…In live-cell imaging, the strategy has been established for thiol-, [30] amine-, [67] and histidine-containing proteins. [68] For example, Zhang and co-workersu sed an amine-reactive isothiocyanate-functionalized mitochondriatargeted AIEgen in live-cell imaging. [67] The study showed good specificity for mitochondrial structures, and was successfully used for real-time monitoring of mitophagy.B ecause reac- www.chemeurj.org tion-based labeling chemistry is only selective for as pecific functional group, but not for as pecific protein, these probes, in principle, would light up am ixture of proteins, as well as reactive biomolecules other than proteins.…”

Section: Microscopic Visualization Of Proteins In Biological Systemsmentioning

confidence: 99%

“…The general working mechanism was discussed in Section 2.1. In live‐cell imaging, the strategy has been established for thiol‐, amine‐, and histidine‐containing proteins . For example, Zhang and co‐workers used an amine‐reactive isothiocyanate‐functionalized mitochondria‐targeted AIEgen in live‐cell imaging .…”

Section: Detection Localization and Quantification Of Proteinsmentioning

confidence: 99%

Fluorogenic Detection and Characterization of Proteins by Aggregation‐Induced Emission Methods

Xie

Wong

Chen

et al. 2019

Chemistry A European J

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Protein is one of the four most important biomacromolecules in living systems. The detection, quantification, localization, and characterization of proteins is essential for an understanding of biological fundamentals, as well as for the diagnostics and treatment of protein‐related diseases. By using intrinsic and extrinsic fluorescence, different techniques have been established to study proteins, many of which are now being routinely used in research laboratories and clinics. This review summarizes the applications of aggregation‐induced emission (AIE) fluorescence in protein science. In contrast to traditional fluorescent dyes, the activation of AIE dyes is mainly attributed to the restriction of intramolecular motions. This unique turn‐on mechanism of AIE dyes allows researchers to develop novel fluorogenic strategies for sensitive, selective, and reliable analysis of proteins. This review focuses on introducing AIE strategies for 1) detection, localization, and quantification of proteins; 2) probing polymer conformational transitions of proteins; 3) characterization of protein–ligand interactions; and 4) evaluation of enzyme activities. Perspectives and challenges with respect to this emerging field of protein characterization are offered.

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Tailored Broad‐Spectrum Emission in Hybrid Aggregation Induced Emission (AIE)‐MOFs: Boosting White Light Efficiency in Electrospun Janus Microfibers

Kachwal,

Mollick,

Tan

2023

Adv Funct Materials

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Advances in energy‐efficient lighting and display technologies demand innovative materials with tailored broad‐spectrum emission properties. Hybrid aggregation‐induced emission metal‐organic frameworks (AIE‐MOFs) offer a promising avenue, combining unique characteristics of organic and inorganic components to yield enhanced luminescence efficiency and robust material stability. The study introduces a spectrum of D (donor)‐A (acceptor) type AIE‐active ligands into MOFs, enabling tunable emission across the visible spectrum, thus underscoring the versatility of these hybridized MOF materials. The emission properties of AIE‐MOFs are further harnessed by integrating them into polymer matrices, resulting in high‐performance electrospun fibers with tunable emission. A significant achievement involves the fabrication of Janus‐type white light‐emitting AIE‐MOF fiber composites via side‐by‐side electrospinning, accomplishing a high quantum yield of 58%, which doubled the performance of homogeneous fibers. Complementing the experimental findings, micro‐Raman and nano‐Fourier transform infrared spectroscopy are employed as local spectroscopic probes, affording a deeper understanding of the material properties and the mechanisms contributing to enhance light emission. In the understanding, this study presents an unconventional implementation of hybrid AIE‐MOFs in Janus‐type structures for white light emission. It significantly improves the efficiency of white light sources in optoelectronics, charting a promising direction for future research in the emergent AIE‐MOF field.

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Electrospun nanofibrous membranes incorporating an imidazole-appended p-phenylene-Cu(ii) ensemble as fluoroprobes for the detection of His-proteins

Abstract: Tetra-imidazole-appendedp-phenylene-Cu(ii) doped nanofibrous membranes can function as “turn-on” portable fluorescence chemoprobes for Histidine.

Cited by 6 publications

References 37 publications

Stimuli‐Responsive Electrospun Fluorescent Fibers Augmented with Aggregation‐Induced Emission (AIE) for Smart Applications

Stimuli‐Responsive Electrospun Fluorescent Fibers Augmented with Aggregation‐Induced Emission (AIE) for Smart Applications

Fluorogenic Detection and Characterization of Proteins by Aggregation‐Induced Emission Methods

Tailored Broad‐Spectrum Emission in Hybrid Aggregation Induced Emission (AIE)‐MOFs: Boosting White Light Efficiency in Electrospun Janus Microfibers

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