Electrospun Nanofibrous Membranes with Essential Oils for Wound Dressing Applications

Lee, Kyung Hwa; Lee, Seungsin

doi:10.1007/s12221-020-9300-6

Cited by 31 publications

(14 citation statements)

References 40 publications

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“…The cell proliferation study conducted in the NIH3T3 cells showcased 1.47 times higher proliferation that suggesting that the PVA nanofibers loaded DOPA-EGF could be used as excellent wound dressing material [69]. Another study reported by Lee and Lee demonstrated the fabrication of electrospun nanofiber based bioactive and interactive wound-dressing materials using PVA, plant-derived palmarosa oil and phytoncide oil [70]. Following fabrication of the nanofibers via emulsion electrospinning, several important studies including water uptake, air/moisture vapor transport and antimicrobial efficacy have been performed to evaluate their potential for wound dressing applications.…”

Section: Synthetic Polymeric Nanofibers Based Wound Dressingsmentioning

confidence: 91%

“…Further, the nanofibers had reasonable levels of gas and moisture vapor permeability and good water uptake ability that may benefit good gas permeability and exudate absorption. The overall results indicated that the developed electrospun nanofibers could be employed as potential bioactive wounddressing materials [70]. Similarly, natural antimicrobial compound thymol (THY) incorporated mesoporous silicon dioxide SBA-15 had been encapsulated to PCL electrospun nanofibers for advanced wound dressing application [71].…”

Section: Synthetic Polymeric Nanofibers Based Wound Dressingsmentioning

confidence: 99%

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Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

Balusamy

Anitha

Uyar

2020

Hacettepe Journal of Biology and Chemistry

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E lektro-eğirme yöntemi ile üretilen nanolifler, son yıllarda nanofibröz yapı iskelelerinin geliştirilmesinde büyük ilgi gördü ve biyomimetik yapıları nedeniyle farklı biyomedikal uygulamalarda kullanıldı. Özellikle, elektro-eğirme yöntemi ile üretilen nanolifler doğal hücre dışı matris (ECM), birbirine bağlı gözenekler, geniş yüzey alanı, işlevselleştirme kolaylığı ve hücre adezyonunu, farklılaşmasını ve proliferasyon davranışını etkilemede büyük önem taşıyan mekanik performans dahil olmak üzere birçok faydalı özellik sergiler. Bugüne kadar, çok çeşitli yararlı özellikleri kabul eden bu nanolifler, yara örtüsü ve doku mühendisliği uygulamalarında kullanılmıştır. Bu derlemede, çeşitli malzemelerin ve yaklaşımların kullanımını gösteren birkaç temsili örneklerle bu alanlarda çeşitli çabaların yapıldığını özetlemektedir. Ayrıca, klinik faz transferine ilişkin gelecekteki yön endişeleri tartışılmıştır. Anahtar Kelimeler Elektro-eğirme, nanolif, yara örtüsü, doku mühendisliği.

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Section: Synthetic Polymeric Nanofibers Based Wound Dressingsmentioning

confidence: 91%

Section: Synthetic Polymeric Nanofibers Based Wound Dressingsmentioning

confidence: 99%

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

Balusamy

Anitha

Uyar

2020

Hacettepe Journal of Biology and Chemistry

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“…Nevertheless, the addition of the EOs improved elasticity and flexibility of the films. In turn, Lee et al [69] modified biomaterial with EOs from palmarosa grasses and hinoki cypresses. Membranes containing palmarosa oil revealed better antimicrobial activity against S. aureus and C. albicans compared to phytoncide oil.…”

Section: Essential-oil-loaded Biomaterialsmentioning

confidence: 99%

“…The use of EO-derived compounds for the production of biomaterials mainly contributed to the increase of their antimicrobial activity and wound regeneration speed. Side effects and limitations related to the addition of EOs to the biomaterial were basically associated with a reduction in physicochemical and mechanical properties, decreasing mechanical strength, swelling degree, water vapor transmission rate, and material wettability [67][68][69][70][71][72][73]. Nevertheless, the rationality of using plant compounds is strictly dependent on the type of wound and treatment strategy, where giving preference to chosen properties requires some consideration.…”

Section: Essential-oil-loaded Biomaterialsmentioning

confidence: 99%

Modifications of Wound Dressings with Bioactive Agents to Achieve Improved Pro-Healing Properties

Vivcharenko

Przekora

2021

Applied Sciences

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The great variety of wounds and the lack of an effective universal treatment method has resulted in high demand for modern treatment strategies. Traditional approaches are often ineffective on a variety of chronic wounds, such as venous ulcers or the diabetic foot ulcer. There is strong evidence that naturally derived bioactive compounds have pro-healing properties, raising a great interest in their potential use for wound healing. Plant-derived compounds, such as curcumin and essential oils, are widely used to modify materials applied as wound dressings. Moreover, dressing materials are more often enriched with vitamins (e.g., L-ascorbic acid, tocopherol) and drugs (e.g., antibiotics, inhibitors of proteases) to improve the skin healing rate. Biomaterials loaded with the above-mentioned molecules show better biocompatibility and are basically characterized by better biological properties, ensuring faster tissue repair process. The main emphasis of the presented review is put on the novel findings concerning modern pro-healing wound dressings that have contributed to the development of regenerative medicine. The article briefly describes the synthesis and modifications of biomaterials with bioactive compounds (including curcumin, essential oils, vitamins) to improve their pro-healing properties. The paper also summarizes biological effects of the novel wound dressings on the enhancement of skin regeneration. The current review was prepared based on the scientific contributions in the PubMed database (supported with Google Scholar searching) over the past 5 years using relevant keywords. Scientific reports on the modification of biomaterials using curcumin, vitamins, and essential oils were mainly considered.

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“…Among the different methods used until now to add bioactive agents to electrospun nanofibers, emulsion electrospinning has gained considerable attention for successfully loading both hydrophilic and hydrophobic agents, and capability to protect the structural integrity and bioactivity of these agents [ 4 , 19 ]. Additionally, it does not require any specific setup and can enhance the solubility of the components of the blend, as well as act as delivery systems, improving its therapeutic performance [ 4 , 18 , 19 , 20 ]. In this method, an emulsion is electrospun into core-sheath structured fibers due to the difference in volatility between the two liquid phases, i.e., one liquid is dispersed into the other in the form of droplets, and during the electrospinning process, the solvent of the dispersed phase evaporates more rapidly while the emulsion droplets move inward and merge in the core of the fibers [ 18 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Chelidoniummajus L. Incorporated Emulsion Electrospun PCL/PVA_PEC Nanofibrous Meshes for Antibacterial Wound Dressing Applications

et al. 2021

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Presently, there are many different types of wound dressings available on the market. Nonetheless, there is still a great interest to improve the performance and efficiency of these materials. Concerning that, new dressing materials containing natural products, such as medicinal plants that protect the wound from infections but also enhance skin regeneration have been or are being developed. Herein, we used for the first time a needleless emulsion electrospinning technique for incorporating Chelidoniummajus L. (C. majus), a medicinal plant widely known for its traditional therapeutic properties, in Polycaprolactone (PCL)/Polyvinyl Alcohol (PVA)_Pectin (PEC) nanofibrous meshes. Moreover, the potential use of these electrospun nanofibers as a carrier for C. majus was also explored. The results obtained revealed that the produced PCL/PVA_PEC nanofibrous meshes containing C. majus extract displayed morphological characteristics similar to the natural extracellular matrix of the skin (ECM). Furthermore, the produced meshes showed beneficial properties to support the healing process. Additionally, the C. majus-loaded PCL/PVA_PEC nanofibrous meshes inhibited Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) growth, reaching a 3.82 Log reduction, and showed to be useful for controlled release, without causing any cytotoxic effect on the normal human dermal fibroblasts (NHDF) cells. Hence, these findings suggest the promising suitability of this novel wound dressing material for prevention and treatment of bacterial wound infections.

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Electrospun Nanofibrous Membranes with Essential Oils for Wound Dressing Applications

Cited by 31 publications

References 40 publications

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

Modifications of Wound Dressings with Bioactive Agents to Achieve Improved Pro-Healing Properties

Chelidoniummajus L. Incorporated Emulsion Electrospun PCL/PVA_PEC Nanofibrous Meshes for Antibacterial Wound Dressing Applications

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