2002
DOI: 10.1002/jbm.10167
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Electrospun nanofibrous structure: A novel scaffold for tissue engineering

Abstract: The architecture of an engineered tissue substitute plays an important role in modulating tissue growth. A novel poly(D,L-lactide-co-glycolide) (PLGA) structure with a unique architecture produced by an electrospinning process has been developed for tissue-engineering applications. Electrospinning is a process whereby ultra-fine fibers are formed in a high-voltage electrostatic field. The electrospun structure, composed of PLGA fibers ranging from 500 to 800 nm in diameter, features a morphologic similarity to… Show more

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Cited by 2,230 publications
(1,531 citation statements)
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“…The possibility of aligning these fibres is of interest in terms of mimicking the ECM. Different materials have been used to generate such fibres: synthetic biodegradable polymers, such as poly-L-lactic acid (PLLA) [27,28], e-caprolactone (PCL) [29], PGA [30], and also natural polymers, such as collagen, silk and DNA. The combination of natural and synthetic fibres has been achieved as well.…”
Section: Electrospinningmentioning
confidence: 99%
“…The possibility of aligning these fibres is of interest in terms of mimicking the ECM. Different materials have been used to generate such fibres: synthetic biodegradable polymers, such as poly-L-lactic acid (PLLA) [27,28], e-caprolactone (PCL) [29], PGA [30], and also natural polymers, such as collagen, silk and DNA. The combination of natural and synthetic fibres has been achieved as well.…”
Section: Electrospinningmentioning
confidence: 99%
“…Hence, the focus has been on the development of 3D artificial matrixes that aim to mimic the extra cellular matrix (ECM), the native surrounding of cells, which is formed of pores, ridges, and nanofibers 6, 7. Those scaffolds are required to provide cell support, to facilitate cell proliferation, differentiation and to offer topographical guidance 8, 9. Due to its cost‐effectiveness and versatility electrospinning has been utilized for the fabrication of fibrous scaffolds with diameters between nanometers to several micrometers 6.…”
Section: Introductionmentioning
confidence: 99%
“…4 Electrospun polymeric nanofiber scaffolds are of particular interest since they mimic the fibrous structure of native extracellular matrix (ECM). 5,6 Thus, fibrous scaffolds are being advanced for clinical applications, such as bladder 7 and trachea. 8 Several reports have observed that nanofiber culture may promote osteogenic differentiation of osteoblast-like cells, embryonic stem cells, and bone marrow stromal cells.…”
Section: Introductionmentioning
confidence: 99%