Electrospun PCL-based polyurethane/HA microfibers as drug carrier of dexamethasone with enhanced biodegradability and shape memory performances

Lv, Haitao; Tang, Dongyan; Sun, Zhonghui; Gao, Jingru; Xu, Yang; Jia, Shiru; Peng, Jing

doi:10.1007/s00396-019-04568-5

Cited by 25 publications

(14 citation statements)

References 38 publications

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“…PCL based PU electrospun microfiber with apatite nanoparticles were prepared to enhance the biological characteristic and shape memory properties. This composite nanofibers showed controlled drug delivery [ 86 ]. The addition of apatite with various ratio to determine the shape memory features and 3 wt% of HA showed excellent recovery with short recovery time.…”

Section: Other Biopolymer Coatingsmentioning

confidence: 99%

Biopolymer Coatings for Biomedical Applications

Nathanael

2020

Polymers

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Biopolymer coatings exhibit outstanding potential in various biomedical applications, due to their flexible functionalization. In this review, we have discussed the latest developments in biopolymer coatings on various substrates and nanoparticles for improved tissue engineering and drug delivery applications, and summarized the latest research advancements. Polymer coatings are used to modify surface properties to satisfy certain requirements or include additional functionalities for different biomedical applications. Additionally, polymer coatings with different inorganic ions may facilitate different functionalities, such as cell proliferation, tissue growth, repair, and delivery of biomolecules, such as growth factors, active molecules, antimicrobial agents, and drugs. This review primarily focuses on specific polymers for coating applications and different polymer coatings for increased functionalization. We aim to provide broad overview of latest developments in the various kind of biopolymer coatings for biomedical applications, in order to highlight the most important results in the literatures, and to offer a potential outline for impending progress and perspective. Some key polymer coatings were discussed in detail. Further, the use of polymer coatings on nanomaterials for biomedical applications has also been discussed, and the latest research results have been reported.

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Section: Other Biopolymer Coatingsmentioning

confidence: 99%

Biopolymer Coatings for Biomedical Applications

Nathanael

2020

Polymers

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“…Polymeric electrospun mats are very versatile materials and they can be used for the production of monolayer and multilayer films and/or sandwich type composites [ 6 , 7 , 8 , 9 ]. Moreover, the electrospun mats can be easily modified by reinforcing the fibers with organic [ 10 , 11 ] and inorganic nanofillers [ 12 , 13 , 14 ] and metallic nanoparticles [ 15 , 16 ]. Therefore, the electrospun mats have gained interest in the industrial sector since they can be easily processed as multifunctional materials and can be applied in different industrial fields such as controlled release of drugs [ 13 ], antioxidants [ 10 , 17 ] and/or antimicrobial [ 17 ] agents; in addition they have piezoelectric properties [ 18 ] and shape memory performance [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Electrospinning of PCL-Based Blends: Processing Optimization for Their Scalable Production

et al. 2020

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In this work poly(ε-caprolactone) (PCL) based electrospun mats were prepared by blending PCL with microcrystalline cellulose (MCC) and poly(3-hydroxybutyrate) (PHB). The electrospinning processing parameters were firstly optimized with the aim to obtain scalable PCL-based electrospun mats to be used in the industrial sector. Neat PCL as well as PCL-MCC and PCL-PHB based mats in different proportions (99:1; 95:5; 90:10) were prepared. A complete morphological, thermal and mechanical characterization of the developed materials was carried out. Scanning electron microscopy (SEM) observations showed that the addition of PHB to the PCL matrix considerably reduced the formation of beads. Both the addition of MCC and PHB reduced the thermal stability of PCL, but obtained materials with enough thermal stability for the intended use. The electrospun PCL fibers show greatly reduced flexibility with respect to the PCL bulk material, however when PCL is blended with PHB their stretchability is increased, changing their elongation at break from 35% to 70% when 10 wt% of PHB is blended with PCL. However, the mechanical response of the different blends increases with respect to the neat electrospun PCL, offering the possibility to modulate their properties according to the required industrial applications.

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“…For areas where degradation should be tunable like drug delivery, PUs are usually developed in forms of electrospun networks [ 160 , 161 ], hydrogels [ 162 , 163 ], membranes [ 164 ] or nanocarriers like micelles [ 165 ] when quick drug release is needed. As PUs degradation process is mainly determined by the SS, degradation rates for tailored drug release time are obtained by varying the type and amount of polyols undergoing hydrolytic and enzymatic degradations such as polyesters-based polyols, to hydrophilic polyols undergoing water uptake and oxidative degradation like polyether-based polyols [ 166 , 167 ].…”

Section: Conventional (Fossil-based) Pu For Biomedical Applicationsmentioning

confidence: 99%

Biobased polyurethanes for biomedical applications

Wendels

Avérous

2021

Bioactive Materials

241

173

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Polyurethanes (PUs) are a major family of polymers displaying a wide spectrum of physico-chemical, mechanical and structural properties for a large range of fields. They have shown suitable for biomedical applications and are used in this domain since decades. The current variety of biomass available has extended the diversity of starting materials for the elaboration of new biobased macromolecular architectures, allowing the development of biobased PUs with advanced properties such as controlled biotic and abiotic degradation. In this frame, new tunable biomedical devices have been successfully designed. PU structures with precise tissue biomimicking can be obtained and are adequate for adhesion, proliferation and differentiation of many cell's types. Moreover, new smart shape-memory PUs with adjustable shape-recovery properties have demonstrated promising results for biomedical applications such as wound healing. The fossil-based starting materials substitution for biomedical implants is slowly improving, nonetheless better renewable contents need to be achieved for most PUs to obtain biobased certifications. After a presentation of some PU generalities and an understanding of a biomaterial structure-biocompatibility relationship, recent developments of biobased PUs for non-implantable devices as well as short- and long-term implants are described in detail in this review and compared to more conventional PU structures.

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Electrospun PCL-based polyurethane/HA microfibers as drug carrier of dexamethasone with enhanced biodegradability and shape memory performances

Cited by 25 publications

References 38 publications

Biopolymer Coatings for Biomedical Applications

Biopolymer Coatings for Biomedical Applications

Electrospinning of PCL-Based Blends: Processing Optimization for Their Scalable Production

Biobased polyurethanes for biomedical applications

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